Demyelinating peripheral neuropathy due to paraproteinemia

Symptoms of autoimmune peripheral neuropathy in general and paraproteinemic demyelinating peripheral neuropathy in particular depend on the location of the nerve and nerve fibers affected. Accordingly, when you have the disease you may experience some of the following symptoms:
Pain and numbness Tingling or burning in the arms and legs can be an early sign of demyelination due to paraproteinemia. This condition usually begins in the toes and feet. The patient may experience pain, usually in the feet and legs.
Besides, the patient may lose feeling in the legs and arms, stepping on sharp objects will not feel. You also cannot feel anything when you touch something that is too hot or cold. Numbness that causes demyelination due to paraproteinemia can make it more difficult for the person to perceive the movement of their legs, which can lead to loss of balance.
Muscular problems Peripheral neuropathy demyelinating due to paraproteinemia causes damage to the nerves that can make it difficult to control muscles and cause muscle weakness. You can feel this symptom when moving parts of your body. Even chores as simple as buttoning a shirt become more difficult or your muscles twitch or spasm. More dangerous, your muscles are also at risk of atrophy.

Digestive and cardiovascular problems: Problems digesting food: Paraproteinaemic demyelinating peripheral neuropathy can make you feel full and heartburn even after just eating a small amount of food. Sometimes you may vomit undigested food.
Heart problems: if the nerves in your heart are damaged, you may feel light-headed or faint when you stand up. Angina is a warning sign of heart disease and a heart attack. Nerve damage to the heart can "hide" this warning sign. You should also look for other heart attack warning signs such as sudden fatigue, sweating, shortness of breath, nausea and vomiting.
Other Symptoms: Sexual problems: With paraparaproteinaemic demyelinating peripheral neuropathy, men may experience erectile dysfunction and women may have trouble with vaginal dryness or difficulty breathing. orgasm.
Bladder problems: You may experience leakage of urine or loss of the feeling of needing to urinate.
About body temperature: You may sweat too little or too much. This can disrupt body temperature control.

2.1. Treatment with Immunoglobulins Paraproteinemic demyelinating peripheral neuropathy can be treated with intravenous globulin. Accordingly, the role of immunoglobulin in the treatment of peripheral neuropathy demyelinating due to paraproteinemia is the first line of treatment in the treatment of this disease;

- Plasma exchange has approximately the same effect as immunoglobulin, which is good for the short-term treatment of demyelinating peripheral neuropathy due to paraproteinemia, but will not be effective and is not recommended for long-term repeat use in the treatment of patients. treat. While Immunoglobulin is used in long-term repeated treatment;
- Most cases of paraproteinemic demyelinating peripheral neuropathy improve fairly rapidly in muscle strength with Immunoglobulin, but improvement is generally not sustainable after several months. Therefore, intravenous immunoglobulin is usually required every 2-6 weeks.
2.2. Immunosuppressants In refractory cases, consider immunosuppressive agents. Corticosteroids are ineffective and sometimes even make the disease worse.
2.3. Plasma exchange The treatment of Paraproteinaemic Demyelinating Peripheral Neuropathy with plasma exchange and Mycophenolate mofetil (Cellcept) is ineffective. Study using cyclophosphamide (Endoxan) and rituximab.
Peripheral peripheral neuropathy due to autoimmune causes many dangerous complications that are difficult to detect at a late stage. Therefore, early examination and detection of disease symptoms at an early stage make treatment easier.
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