Effects of bone marrow failure on the body

Bone marrow failure is a medical condition that causes the bone marrow to not produce enough cell lines from hematopoietic stem cells, leading to a decrease in red blood cells, white blood cells, and platelets in the peripheral blood. Therefore, bone marrow failure will cause the patient's body to lack one or more blood cell lines and affect the whole body.

Bone marrow failure is a clinical syndrome characterized by a decrease in red blood cells, granulocytes and platelets in the blood, and the bone marrow is also replaced by adipose tissue due to a decrease in hematopoiesis in the marrow region. Up to 70% of bone marrow failure is unexplained due to susceptibility gene mutations, the rest is due to genetic or acquired causes such as:
Drugs: analgesics, anti-inflammatory, antihypertensive, anti-inflammatory drugs. arrhythmias, antithyroid or antibiotics (especially chloramphenicol) Chemically: benzene, chlorinated hydrocarbons, organophosphates Viral infections: Epstein-Barr, hepatitis virus, Parvovirus, HIV Autoimmune disorders: thyroid disease, lupus erythematosus, rheumatoid arthritis Pregnancy

Bone marrow failure is a dangerous disease that seriously affects the health of the patient. Manifestations of bone marrow failure can progress slowly and depend on the severity of the disease, including:
Symptoms of anemia such as paleness, fatigue, shortness of breath,... Anemia occurs gradually over the course of a day. more severe and difficult to recover with blood transfusion. Agranulocytosis: possible fever or infection Platelet disorder: hemorrhagic symptoms due to thrombocytopenia such as bleeding under the skin, bleeding of the oral mucosa, menorrhagia,...

About the changes in the body that are seen through blood and bone marrow tests that show the following:
2.1. Blood tests Hematology: decreased 3 lines or maybe only 1 peripheral cell line at the beginning and gradually increased after a few days or weeks. Low isochromic, isochromic, reticulocytosis Anemia Increased concentration of hematopoietic growth factors such as erythropoietin, thrombopoietin and granulocyte growth factor High serum iron concentration, prolonged iron clearance 2.2. Marrow test Myelogram: cell density decreases to different degrees, typically fat-filled spaces and very few blood cells. Occasionally, the marrow granules are multicellular, but the platelet protozoa is usually reduced. Marrow biopsy: marrow is poor in cells, rich in fat and connective tissue. In general, severe bone marrow failure has a mortality rate of about 25% in the first 4 months and 50% within 1 year if the patient does not receive a marrow transplant. . In the case of stem cell transplantation, the response rate falls around 70%. In addition, immunosuppressive therapy can provide similar results to marrow transplantation in idiopathic myelosuppression, but after 10 years, up to 40% of patients develop paroxysmal nocturnal hemoglobinuria, a myelogenesis and acute myeloid leukemia. Because of the extremely serious effects on physiological functions and body activities, bone marrow failure needs to be detected early and treated promptly to improve survival and thoroughly treat patients.

Periodic health check-ups help to detect diseases early, so that there are treatment plans for optimal results. Currently, Vinmec International General Hospital has general health checkup packages suitable for each age, gender and individual needs of customers with a reasonable price policy, including:
Health checkup package general Standard 2020 General health check-up package VIP 2020 General health check-up package Special 2020 General health check-up package Children 2020 General health examination package Work permit - Issuance of work permits Examination results of people sick will be returned home. After receiving the results of the general health examination, if you detect diseases that require intensive examination and treatment, you can use services from other specialties at the Hospital with quality treatment and services. outstanding customer service.
To register for examination and treatment at Vinmec International General Hospital, you can contact the nationwide Vinmec Health System Hotline, or register online.