Significance of Anti beta2 glycoprotein IgG . test

The Anti beta2 glycoprotein IgG test is used to diagnose antiphospholipid syndrome, which causes unexplained blood clots or repeated spontaneous abortions.

Beta 2 glycoprotein (β2GPI) is a type of lipoprotein that is synthesized from the liver and released into the bloodstream. Anti beta 2 - Glycoproteins have the characteristics of an autoantibody produced by the immune system, so they target lipid proteins found in the platelets and outermost cells of the body. Beta 2 glycoprotein consists of two types of antibodies, IgG and IgM.
In the body, Beta 2 - Glycoprotein is directly involved in blood clotting. The presence of Anti beta 2 - Glycoprotein may increase the risk of intravascular thrombosis and is also associated with thrombocytopenia, preterm birth, preeclampsia or miscarriage.

Normally, the Anti beta 2 - Glycoprotein test is ordered by the doctor together with the Anti Phospholipid test kit in the following cases:
Used for young patients who have a venous or arterial blood clot but no blood clots. risk factor. Used for pregnant women with a history of miscarriage, stillbirth from 2 or more times. People who have ever had eclampsia, slow fetal growth. Used for people with signs of anti-phospholipid syndrome such as: Headache, chest tightness, shortness of breath, seizures, stroke, intellectual impairment,... Sometimes doctors also suggest patients to do Anti beta 2 - Glycoprotein test to find the cause of thrombocytopenia.

Anti beta 2- Glycoprotein test is performed on venous blood samples by ELISA (Enzyme-Linked Immunosorbent Assay) method to look for IgG/IgM antibodies.
The results of the Anti beta 2- Glycoprotein test include:
Anti beta 2- Glycoprotein IgG:
Negative: 0 - 8.0 U/ml; Suspicious: 8.0 - 10.0 U/ml; Positive: > 10.0 U/ml. Anti beta 2- Glycoprotein IgM:
Negative: 0 - 8.0 U/ml; Suspicious: 8.0 - 10.0 U/ml; Positive: > 10.0 U/ml. Patients with negative results but still experiencing clinical symptoms should be monitored and re-tested Anti beta 2- Glycoprotein after 4 to 6 weeks.

Antiphospholipid syndrome (APS) is an autoimmune disease that causes unexplained blood clots or spontaneous spontaneous abortions.
Anti-Beta 2 - Glycoprotein test is performed in concert with other antiphospholipd (aPL) tests to diagnose antiphospholipid syndrome (APS). These tests are performed to provide parameters including: Anti-Cardiolipin IgG/IgM Index, Antiphospholipid IgG/IgM Index, Anti β2 - Glycoprotein IgG/IgM Index and LA Index.
Anti-Beta 2 - Glycoprotein test should be done 2 times, about 12 weeks apart. If the test result is positive on both occasions it is persistently positive, if the test result is positive on both occasions it is considered transient positive and may be due to a number of conditions in the body causes such as: Infection, side effects of drugs or changes in the body during pregnancy.
In summary, the Anti beta2 glycoprotein IgG test is commonly used in patients with antiphospholipid syndrome. The results of the test will be the basis for determining the cause of repeated miscarriages, pre-eclampsia, gestational diabetes, lupus or thrombosis... in the patient.
To get accurate results, patients need to go to a reputable medical facility with modern equipment to conduct an anti Beta 2 - Glycoprotein test. Currently, the Laboratory - Vinmec International General Hospital is one of the leading prestigious addresses in the country, trusted by many patients. Thanks to the use of modern machines and equipment to check and analyze patient samples, it has provided accurate information and indicators, helping doctors to assess the general health status of patients. testing, early detection of disease and timely treatment plan. In particular, with a space designed according to 5-star hotel standards, Vinmec guarantees to bring patients the most comfort, friendliness and peace of mind when visiting and receiving treatment at the hospital.