Axicabtagene Cioleucel Suspension: Uses, indications and precautions when using

Most cancers are malignancies, requiring complex treatment with drugs, chemotherapy, radiation, or surgery. One of the dangerous types of cancer involving the lymph nodes is non-Hodgkin's lymphoma. The treatment of non-Hodgkin's lymphoma is quite complicated, in which immunotherapy has been quite effective, most notably the drug Axicabtagene Cioleucel Suspension.

Axicabtagene Cioleucel Suspension is used to treat non-Hodgkin lymphoma that has not gone into remission or has come back after at least 2 other therapies. Axicabtagene Cioleucel Suspension is also known as immunotherapy.
Axicabtagene Cioleucel Suspension is made from a patient's white blood cells and is given only to the patient. White blood cells are altered to make a special protein: chimeric antigen receptors (CARs) that help the body slow or stop the growth of certain cancer cells.

Doctors often give patients 3 days for chemotherapy before starting treatment with Axicabtagene Cioleucel Suspension, this can be seen as a step to prepare the body.
Axicabtagene Cioleucel Suspension is given by slow intravenous injection as directed by your doctor, injected over 30 minutes. To reduce the risk of side effects, your doctor may prescribe supportive medications (such as acetaminophen, diphenhydramine) before injecting Axicabtagene ciloleucel.
The dose of the drug will be calculated based on the patient's health condition and weight. Ideally, the patient should find a place near the treatment site and stay for at least 4 weeks (the accommodation is less than 2 hours drive from the treatment place). Doctors need to check if the treatment is working and help the patient manage side effects.

Headache, fatigue or loss of appetite are possible side effects when using Axicabtagene Cioleucel Suspension. However, patients should pay close attention to monitor and notify medical staff as soon as any effects persist or get worse.
Axicabtagene Cioleucel Suspension is used to treat cancer, but it can increase the risk of developing other cancers (although very rare). In addition, this product severely reduces a person's blood cells, reduces their ability to fight infections, and increases the risk of anemia or bleeding problems.
The sick person is more likely to have serious (rarely fatal) infections and any infections they have could get worse. Tell your doctor as soon as you start developing unusual lumps or lumps, swollen lymph nodes, signs of infection (such as sore throat that doesn't go away, fever, chills), easy bruising, unusual bleeding. Usually, unusual tiredness.

Before starting treatment with Axicabtagene Cioleucel Suspension, the patient should tell his or her doctor or pharmacist if there is a history of previous allergy to the drug or any other allergies and the patient's medical history, especially to : past or present infection status (including hepatitis, HIV ).
Axicabtagene Cioleucel Suspension may make the patient more susceptible to infection or may worsen any existing infection. Avoid contact with people who have high-risk infections (such as chickenpox, measles, flu).
Do not get vaccinated without your doctor's approval, and avoid contact with people who have recently received a live vaccine (such as the nasal flu vaccine).
To reduce the risk of bruising or injury, use caution with sharp objects such as razors and nail clippers, and avoid activities such as contact sports.
The drug can make the patient dizzy, affect the body's coordination or make it difficult for the patient to concentrate and think clearly. Alcohol or marijuana can worsen these effects, so people taking Axicabtagene Cioleucel Suspension should not drive, use machines, or do anything that requires alertness until they are sure they can. do it safely (at least 8 weeks after being treated as recommended by the manufacturer). Limit alcoholic beverages during treatment with Axicabtagene Cioleucel Suspension.
Tell the doctor if the patient is pregnant or planning to become pregnant. Patients should not become pregnant while using Axicabtagene Cioleucel Suspension because it may harm an unborn baby. If the patient becomes pregnant, talk to the doctor immediately about the risks and benefits of the drug.
It is not known whether Axicabtagene Cioleucel Suspension passes into breast milk, patients should consult their doctor before taking the medicine if they are breast-feeding.
Tests such as complete blood count... should be performed before and after the patient is treated with this medicine. Women of childbearing age should have a pregnancy test before using Axicabtagene Cioleucel Suspension.
After being treated with Axicabtagene Cioleucel Suspension, the patient should not donate blood, organs, tissues or cells. If a patient's dose of Axicabtagene Cioleucel Suspension is interrupted or terminated, the patient should contact their doctor immediately to establish a new dosing schedule. The product Axicabtagene Cioleucel Suspension needs to be used in the hospital, the drug should not be stored at home.

Reference source: webmd.com