Indications and notes when using Midantin 125/31.25

Midantin is a drug belonging to the group of penicillin antibiotics, commonly used in the treatment of infections of the upper respiratory tract, lower respiratory tract, urinary tract... The correct use of the drug will bring the highest effectiveness, limit minimize possible side effects.

Midantin belongs to the group of penicillin antibiotics that contain Amoxicillin trihydrate and Clavulanic acid. The drug is prepared in the form of powder for oral suspension with different strengths such as Midantin 875/125, Midantin 250/31.25 or Midantin 125/31.25.
Amoxicillin is an important component of the drug Midantin, also a semi-synthetic beta-lactam antibiotic with a broad bactericidal spectrum against many Gram-positive and Gram-negative bacteria thanks to its ability to inhibit bacterial cell wall synthesis. bacteria.
Meanwhile, clavulanic acid has high affinity and ability to bind with a number of competitive lactamases. This ingredient has the ability to inhibit lactamase enzymes produced by most Gram-negative bacteria and Staphylococcus. Clavulanic acid is often combined with amoxicillin because of its ability to protect against degradation by lactamases and to extend the antibacterial spectrum of amoxicillin. From there, they are effective against amoxicillin-resistant lactamase-producing bacteria when used alone.
With the combination of amoxicillin and clavulanic acid, the use of Midantin is to treat bacterial infections and infections with high efficiency.

2.1. Indications Using Midantin in the treatment of otitis media, pharyngitis, tonsillitis, laryngitis, bronchitis, sinusitis and especially pneumonia. Treatment of patients with urinary tract infections, skin infections and gonorrhea. 2.2. Contraindications Midantin is contraindicated for people allergic to penicillin, cross-allergic to cephalosporins. In addition, patients with infectious mononucleosis or lymphocytic leukemia should not use this drug.

3.1. Dosage of Midantin is used with reference doses as follows:
Usual dose:
Adults: Use at a dose of 250 mg - 500 mg (calculated on amoxicillin), every 8 hours. Children under 10 kg: Use with a dose of 125 - 250mg, every 8 hours. Children under 10-20 kg: Use at a dose of 20-40 mg/kg body weight/day. Higher doses:
Usually used as a single dose or used in short courses, indicated in some diseases such as:
Treatment of periodontal abscesses: Use a single dose of 3g or repeat again later about 8 o'clock. Treatment of uncomplicated acute urinary tract infections: Use a single dose of 3g or repeat after 10-12 hours. To prevent endocarditis: Use as a single dose of 3 g, 1 hour before procedures such as tooth extraction. Patients with severe or recurrent respiratory tract infections: Use a high-dose regimen of 3g amoxicillin twice a day. Children 3 - 10 years old with otitis media: Use at a dose of 750 mg / time, 2 times a day, for 2 days if necessary. 3.2. How to use Midantin is prepared as a powder for oral suspension:
First, you pour the powder into the bottle and then pat it so that the entire amount of powder flows to the bottom of the bottle. Pour cooled boiled water into the bottle to the marked line, shake vigorously by hand to dissolve the powder into the water. You need to pay attention to shake well to completely dissolve the powder before taking the medicine.

Midantin can cause some side effects such as:
Diarrhea, stomach pain, vomiting or nausea, skin rash, itching, hives. Difficulty breathing or swallowing, feeling wheezing. Itching and increased vaginal discharge, yellowing of the skin or eyes. During the use of Midantin, you need to notify your doctor immediately if you have any unusual problems.

Midantin has the potential to interact with some of the following drugs
Probenecid : Concurrent use of Probenecid with Midantin may increase the concentration of Amoxicillin in the blood. Oral Anticoagulants: Using oral anticoagulants at the same time as Midantin may cause abnormal prolongation of Prothrombin time. Therefore, patients need to have their anticoagulant dose adjusted. Allopurinol: Concomitant administration of Allopurinol with Midantin increases the incidence of rash in patients. Oral contraceptives: Midantin has the ability to reduce the reabsorption of estrogen and reduce the effectiveness of oral contraceptives.

Some of the following groups of people need to be careful when using Midantin.
Patients with a history of cholestatic jaundice or liver dysfunction. Patients with severe renal failure or undergoing hemodialysis. Pregnant women should only use Midantin during pregnancy when clearly needed. Amoxicillin in the drug is excreted in breast milk, so caution should be exercised when Augmentin is administered to a nursing woman. Patients with hepatic impairment should be cautious when determining the dose and monitor liver function regularly during the use of Midantin. Thus, you have just learned some information about Midantin, especially indications and notes when taking the drug. This information is for reference only, during use, you need to follow the instructions of a specialist to achieve the best treatment effect.