Uses of Artichoke 40 inj

Atisolu 40 inj is a product of An Thien Pharmaceutical Joint Stock Company, prepared in the form of lyophilized powder for injection, with the main ingredient being methylprednisolone. Artichoke is an effective anti-inflammatory drug, used mainly for conditions such as skin disease, abnormal adrenal cortex function, gastrointestinal disease, hematology, respiratory, liver, eye, Nervous, rheumatism, arthritis, tendinitis,...
Atisolu drug is packaged according to box specifications of 1 vial with a tube of solvent, a box of 3 vials with 3 tubes of solvent or a box of 5 vials with 5 ampoules. solvent. In which, the ampoule of distilled water for injection has a content of 1ml. The main active ingredient methylprednisolone in the drug has a corresponding concentration of 40mg, in the form of methylprednisolone sodium succinate.

2.1. Indications for use of Atisolu 40 inj Atisolu 40 inj is prescribed by a doctor for use in the following cases:
Allergic disorders. People with abnormalities in the function of the adrenal cortex. People with arthritis, tendonitis or rheumatism. People with diseases of the skin, hematology, nerves, kidneys, liver, eyes, respiratory, gastrointestinal tract. People with nerve injury. People with tumors increase blood calcium. Treatment of pericarditis. 2.2. Uses of the drug Artichoke 40 inj Pharmacodynamics
The main active ingredient methylprednisolone in the drug Artichoke is a glucocorticoid (6 - alpha - methyl derivative of prednisolone), which has anti-allergic, anti-inflammatory and immunosuppressive properties. The drug inhibits inflammation by preventing extravasation and leukocyte infiltration into tissues. Systemic administration of methylprednisolone can reduce the number of lymphocytes, increase neutrophils, thereby improving inflammation in the body.
On the other hand, methylprednisolone also inhibits the function of tissue macrophages and lymphocytes. Moreover, this active substance also reduces inflammatory response by its ability to reduce prostaglandin synthesis due to the activation of phospholipase A2.
Pharmacokinetics
The bioavailability of the active ingredient methylprednisolone is close to 80% with average peak plasma concentrations 1 to 2 hours after dosing. Atisolu 40 inj has a short-acting effect on pituitary suppression (about 11⁄2 days). According to studies, methylprednisolone is extensively metabolized in the liver in the same way as hydrocortisone. After metabolism, the drug is excreted in the urine with a half-life of approximately 3 hours.

Artichoke drug is prepared in the form of lyophilized powder for injection, can be injected locally or intramuscularly (IM), with specific dosages as follows:
Local dose of Artisolu:
Treatment of rheumatism or arthritis From 1 to 5 weeks: Inject from 4 to 80mg methylprednisolone depending on the joint. Treatment of tendonitis: Inject 4-40mg of methylprednisolone. Treatment of skin diseases: Inject 20-60mg of methylprednisolone. * Intramuscular (IM) dose Atisolu:
Treatment of hypersecretion of adrenal hormone: 40mg methylprednisolone injection within 2 weeks. Treatment of rheumatism: 40-120mg methylprednisolone injection for a week. Treatment of skin diseases: Inject 40-120mg of methylprednisolone from 1 to 4 weeks. Asthma: 80-120mg methylprednisolone IM injection once a week or every 2 weeks for allergic rhinitis. Treatment of exacerbations of multiple sclerosis: Inject 160mg methylprednisolone/day for one week, then adjust the injection dose to 64mg/day for one month.

Artisolu 40 inj medicine can cause some side effects from common to rare for patients during treatment, specifically:
Common side effects of Atisolu:
Nervous excitability or insomnia . Hairy. Indigestion or increased appetite. Epistaxis. Athritis. Diabetes. Glaucoma or cataracts. Rare side effects of Atisolu:
Convulsions, brain pseudotumor, dizziness, psychosis, headache, delirium, hallucinations, mood swings, euphoria. Hypertension or edema. Skin atrophy, acne growth, tissue hyperpigmentation or skin bruising. Nausea, vomiting, esophagitis, peptic ulcer, pancreatitis, abdominal distension. Pituitary-adrenal axis suppression, Cushing's syndrome, growth retardation, alkalosis, sodium retention, amenorrhea, lactose intolerance, hypokalemia or hyperglycemia. Osteoporosis, muscle weakness or broken bones. Patients should tell their doctor if they notice any of these symptoms after taking Atisolu 40 inj. Early recognition and treatment will help patients avoid serious health consequences.

5.1. What precautions should be taken when treating with Atisolu 40 inj Before and during the use of Atisolu 40 inj, you need to note a few things below:
Patients with osteoporosis, mental disorders, duodenal ulcers Intestinal ulcer, peptic ulcer, hypertension, growing children, heart failure or new vascular access need to use Artisolu with extreme caution. The elderly tend to be more sensitive to the adverse effects of the drug, so systemic corticosteroids should be used with caution, preferably at the lowest dose and for only the short term. Avoid abrupt discontinuation of Atisolu during stress or after prolonged treatment as this may lead to acute adrenal insufficiency. When taking high doses of Artichoke can affect the effectiveness of the vaccine. Pregnant women or nursing mothers need to talk with their doctor carefully before being treated with Atisolu. 5.2. Cases of contraindications to the use of Atisolu 40 inj Atisolu drug is not recommended for use in the following cases:
People with hypersensitivity to the active ingredient methylprednisolone or other active ingredients in the drug.
Patients with advanced liver disease or severe renal failure. People who are using live vaccines. People with systemic fungal infections. People with some digestive diseases. 5.3. What drugs interact with Artisolu 40 inj? The use of Atisolu 40 inj may have an interaction reaction that reduces the effectiveness of the drug and increases the rate of serious side effects when used with some other disease-modifying drugs. Here is a list of drugs that may interact with artichokes:
May affect the metabolism of erythromycin, ciclosporin, phenytoin, phenobarbital, ketoconazole, carbamazepine and rifampicin because the active ingredient methylprednisolone is a substrate of the enzyme P450 3A. and is an inducer of the cytochrome P450 enzyme. The potency of methylprednisolone may be reduced if taken with diuretics that lower blood potassium, rifampin, phenobarbital or phenytoin. Because methylprednisolone has the potential to increase blood glucose, a higher dose of insulin is required. Some functional foods. In order to avoid interactions when using Atisolu, patients should inform their doctor about the list of medications and substances they are taking, including herbs and vitamin supplements. In addition, you also need to talk to your doctor about your current health condition and previous medical history to assess the risks and benefits of taking Atisolu.
5.4. Instructions for proper storage and handling of Atisolu medicine Each pharmaceutical product has its own way of preserving to ensure the best quality of the drug. For Atisolu 40 inj, you should store the medicine in a cool area (no more than 30 degrees Celsius), avoid moldy places or direct sunlight. You need to be careful not to store the medicine in the refrigerator or bathroom, and do not use it if it shows signs of mold, deformation, color change or expiration. In case you want to destroy expired Atisolu medicine, you need to consult your doctor to handle the medicine safely, avoiding environmental pollution.
Atisolu medicine 40 inj is used in the form of intramuscular or local injection to treat problems such as skin diseases, arthritis, stomach and respiratory diseases, ... To ensure safety when used Atisolu, the patient should take the drug according to the detailed instructions from the specialist. Follow Vinmec International General Hospital website to get more health, nutrition and beauty information to protect the health of yourself and your loved ones in your family.