Uses of Binexamorin

Binexamorin is a drug belonging to the group of hormones, hormones. Used in the treatment of non-insulin-dependent type 2 diabetes mellitus in adults, in combination with diet and exercise. Binexamorin has the active ingredient Glimepiride as the main active ingredient. The drug is prepared in the form of tablets, packing is a box of 3 blisters, 5 blisters, 10 blisters x 10 tablets.

Binexamorin is made up of the active ingredient Glimepiride.
2.1. Pharmacodynamics of the active ingredient: Glimepiride is essentially a new generation of hypoglycemic sulfamide belonging to the group of sulfonylureas used in the treatment of type 2 diabetes.
2.2. Pharmacokinetics of the active substance: Absorption: Glimepiride has 100% bioavailability. Maximum plasma concentrations were reached approximately 2 hours and 30 minutes after oral administration (mean 0.3 mcg/mL after repeated doses of 4 mg). Food does not significantly alter the absorption of the drug, but does decrease the rate of absorption slightly.
Distribution: The volume of distribution of Glimepiride is very low (approximately 8.8 l), similar to the volume of distribution of albumin. Glimepiride is strongly bound to plasma proteins (>99%) and has a low clearance (48 ml/min). Elimination half-life is 5 to 8 hours. Metabolism: Glimepiride's hydroxy and carboxyl derivatives are two hepatic metabolites that have been detected in both urine and feces. Elimination: Following oral administration of Glimepiride, the terminal half-lives of the metabolites are 3 to 6 hours and 5 to 6 hours, respectively. Binexamorin is indicated for use in combination with diet and exercise to control blood sugar in adults with non-insulin dependent type 2 diabetes.

3.1. How to use the drug Binexamorin: For the drug Binexamorin, patients use it orally. The drug should be taken with the first breakfast or main meal of the day.
3.2. Dosage of Binexamorin: The recommended dosage of Binexamorin is as follows:
Initial dose:
In previously untreated patients: The recommended dose is 1-2 mg/day. Debilitated, malnourished or elderly patients, patients with hepatic or renal impairment, patients at risk of hypoglycemia: The recommended dose of 1 mg/day. Patients previously treated for diabetes: Recommended dosage 1-2mg/day, maximum 2mg/day. Maintenance dose:
In patients already receiving Glimepiride 1 mg/day, increase dose to 2 mg/day if desired blood glucose levels are still not achieved after 1 to 2 weeks of treatment. Following up to 2 mg dose, subsequent dose adjustment is dependent on tolerability and response. The dose should be increased slowly, each time not exceeding 2mg/day, at intervals of 1-2 weeks, the maximum dose is 8mg/day. 3.3. How to handle forgetting, overdosing Missed dose:
If you miss a dose, take it as soon as possible, usually within 1-2 hours compared to the time specified in the prescription. If the time is too long, skip the missed dose and use it exactly as directed. Do not take a double dose at the same time.
Overdose:
If any unwanted symptoms occur when using an overdose of Binexamorin. It is necessary to immediately notify the treating doctor or the nearest medical facility for timely handling.
3.4. Binexamorin is contraindicated in the following cases:
Cases where the patient is allergic or sensitive to Glimepiride, Sulfonylurea or Sulfonamide or any of its ingredients. Patients with insulin-dependent diabetes mellitus, coma and diabetic keto-acidosis. Patients with severe liver/kidney failure, women who are pregnant or planning to become pregnant, and women who are breastfeeding: Should switch to insulin. Do not give the medicine to children.

Notes and cautions when using Binexamorin:
Be aware of the risk of hypoglycemia or loss of blood glucose control. Binexamorin should not be used in patients with rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Pregnant women, intending to become pregnant: Do not use the drug for this object. Should switch to insulin. Lactation: Consider the benefit/risk to the mother. It is advisable to switch to insulin or discontinue breast-feeding if treatment with binexamorin is absolutely necessary. Drivers and Machine Operators: Use caution while driving and operating machinery. Side effects when using Binexamorin:
The most important undesirable effect when using the drug is hypoglycemia.
Other side effects:
Dizziness, headache, dizziness. Feeling of pain in the epigastrium, nausea, vomiting, abdominal pain, diarrhea. Temporary visual disturbance at the start of the drug. due to changes in blood sugar levels. In individual cases, there may be elevated liver enzymes and impaired liver function. Severe/mild thrombocytopenia. Symptoms of parasympathetic conditioning include sweating, moist skin, tachycardia, anxiety, palpitations, angina, and arrhythmias. Binexamorin drug interactions and incompatibilities:
Drugs that increase the hypoglycemic effect of Glimepiride: Insulin, oral antidiabetic drugs, chloramphenicol, MAOIs, coumarin derivatives, miconazole, phenylbutazone.
Drugs that reduce the effect of Glimepiride: Acetazolamide, diuretics, barbiturates, glucagons, phenytoin.
The active ingredient Glimepiride may alter the effect of coumarin anticoagulants.
Storage of Binexamorin:
Store the medicine at room temperature, avoid direct sunlight, avoid moisture, keep in a cool and dry place.
Above is all the necessary information when using the drug Binexamorin. Binexamorin is a prescription drug, patients need to consult their doctor during use. Hopefully the article has provided all the necessary notes for readers when using Binexamorin.