Uses of Panatel 125

What is Panatel 125? Panatel is a product of the Indian company Medopharm, prepared in the form of film-coated tablets. Panatel 125 has the main active ingredient is Pyrantel with a strength of 125mg. Pyrantel is highly effective against roundworms (Ascaris lumbricoides), worms Trichostrongylus spp., pinworms (Enterobius vermicularis), helminths (Trichinella spiralis) and hookworms (Ancylostoma duodenale, Necator americanus). Pyrantel has no effect on hairworms (Trichuris trichiura). The mechanism of action of Pyrantel is neuromuscular blockade on drug-sensitive worms through the release of acetylcholine and inhibition of cholinesterase, resulting in rigidity and expulsion of the worms due to intestinal peristalsis.

Panatel 125 is indicated in the treatment of infections with pinworms, roundworms, hookworms and strongyloides. The use of Panatel 125 is contraindicated in patients with hypersensitivity to Pyrantel and in children under 2 years of age, because safety has not been established in this age group.

3.1 Dosage Adults:
Treatment of roundworms, pinworms, hookworms, Trichostrongylus worms: Use a single dose of 10 mg/kg (base form), maximum 1g/dose. Efficacy will be higher if the dose is repeated after 2-4 weeks of treatment.
Hookworm infection: A single dose of 20 mg/kg/day (maximum 1g/dose) is recommended, for 2 consecutive days; or 10mg/kg/day (maximum 1g/dose), for 3 consecutive days.
Isolated roundworm infections: A single dose of 5 mg/kg (maximum 1 g/dose) is recommended.
Trichinosis: Recommended dose 10 mg/kg/day (maximum 1g/dose) for 5 consecutive days.
Children over 2 years old:
Ascariasis, hookworm infection: The recommended dose is 10 mg/kg once daily for 3 days, maximum 1g/dose.
Streptobacillus moniliformis infection: 11mg/kg/dose every 2 weeks for 3 doses is recommended.
Pinworm infection: Treatment of the whole family is recommended to prevent reinfection. Weight-based dosing in children, given as a single dose and repeated over 2 weeks to prevent reinfection.
Children from 11 to 16 kg: 125 mg is recommended. Children 17 to 28 kg: 250 mg is recommended. Children 29 to 39 kg: 375 mg is recommended. Children 40 to 50 kg: 500 mg is recommended. Children 51 to 62 kg: 625 mg is recommended. Children 63 to 73 kg: 750 mg is recommended. Children 74 to 84 kg: 875 mg is recommended. Children > 84 kg: Recommended dose 1000 mg Hookworm infection: A single dose of 20 mg/kg/day for 2 consecutive days or 10 mg/kg/day for 3 consecutive days is recommended.
Isolated roundworm infections: A single dose of 5 mg/kg is recommended.
Trichinosis: A dose of 10 mg/kg/day is recommended for 5 consecutive days.
Other subjects:
Renal impairment: No dose adjustment of Panatel is required in this subject Hepatic impairment: No dose adjustment of Panatel is required in this subject. 3.2 How to use Panatel should be taken between meals, patients can drink with milk or juice. Before and after taking the drug Panatel do not need to follow a special diet, do not fast and do not need to use other bleach.

Patients using Panatel may experience side effects including:
Central nervous system: Dizziness, dizziness, headache Gastrointestinal: Abdominal cramps, diarrhea, nausea, vomiting, loss of appetite Other: Increased liver enzymes, fever, drowsiness

Patients using Panatel should note the following issues:
Care should be taken when using Panatel in patients with impaired liver function. Use caution when administering Panatel to malnourished or severely anemic patients. Ideally, patients with anemia, dehydration, or malnutrition should receive supportive treatment prior to treatment with Pyrantel. Children and adults using the drug may experience toxicity including increased alcohol levels, lactic acidosis, convulsions, and respiratory depression. Overdose: Symptoms of a Panatel overdose include difficulty breathing, seizures, muscle spasms, or severe muscle weakness. When there are signs of overdose, the patient should immediately go to the nearest medical facility for treatment. When treating pinworms should treat all family members, thoroughly clean the place and clothes to kill all pinworm eggs. In addition, measures should be taken such as washing hands frequently and cutting fingernails neatly, wearing underwear day and night, mopping or vacuuming floors regularly for a few days after treatment, regularly washing. bed linen, clothes after treatment and keep the toilet clean. Pregnancy: The use of Pyrantel in pregnant women has not been well studied. Therefore, Panatel should only be used when clearly needed after the first 3 months of pregnancy. Lactation: It is not known to what extent Pyrantel is secreted into breast milk, but because the drug is poorly absorbed, drug concentrations in breast milk may not be clinically relevant The article provides general information. about Panatel 125. The above information is for reference only and cannot replace the guidance of medical personnel. Therefore, patients need to contact their doctor or pharmacist before taking to ensure maximum effectiveness of the drug.
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