Uses of Rosecana

Rosecana is indicated for the treatment of severe acne. In the process of taking the drug, the patient should strictly adhere to the dosage, frequency and way of using the drug that the doctor has recommended.

Rosecana belongs to the group of drugs for the treatment of dermatological diseases, researched and manufactured by Phil Inter Pharma Co., Ltd - Vietnam. Rosecana has been highly regarded by doctors for its ability to effectively treat severe acne.
Rosecana drug is prepared in the form of soft capsules, box includes 3 blisters x 10 tablets, each tablet contains the main ingredient is isotretinoin 20mg content. In addition, Rosecana also has a combination of other auxiliary excipients, which enhance the pharmacodynamics and pharmacokinetics of the main active ingredient in the drug.

2.1. Uses of the active ingredient Isotretinoin Pharmaceutical ingredient Isotretinoin is known to be a stereoisomer of Tretinoin. According to some clinical studies, Isotretinoin has the effect of reducing the activity and size of the sebaceous glands. In fact, when the hair follicles of the sebaceous glands increase keratinization of the epithelial cells, it will clog the sebaceous glands and form acne nodules, which in turn leads to inflammatory lesions. Active ingredient Isotretinoin inhibits the production of sebaceous cells and re-establishes the cell differentiation program. Normally, sebum is the substance that creates favorable conditions for the growth of Propionibacterium acnes bacteria. So, the sebaceous-reducing effect of Isotretinoin may prevent the growth of this acne-causing bacteria in hair follicles.
Below are the pharmacokinetic properties of the active ingredient Isotretinoin:
Absorption: Isotretinoin absorption from the gastrointestinal tract varies greatly. When taken with food, the bioavailability of this substance is doubled compared with oral administration on an empty stomach. Distribution: Isotretinoin is highly bound to plasma proteins, about 99.9% is Albumin. Studies have shown that the concentration of isotretinoin in the skin is half of the serum concentration. Metabolism: After oral administration, Isotretinoin is metabolized to 3 major substances, including tretinoin, 4-oxo-isotretinoin and 4-oxo-tretinoin. Elimination: In patients with acne, the mean half-life of isotretinoin is 19 hours unchanged. Among them, the metabolite 4-oxo-tretinoin has a mean half-life of 29 hours. 2.2. Indications and contraindications to the use of Rosecana Rosecana is a prescription drug used for severe acne disease that has been resistant to standard treatments with topical medications or oral antibiotics. However, the use of Rosecana should be avoided in the following subjects without consulting a doctor:
Patients with hypersensitivity or allergic reactions to the ingredient Isotretinoin or other excipients contained in the drug. The patient has an excess of vitamin A in the body. People with liver failure or high blood lipid levels. The patient is taking concomitant antibiotics of the tetracycline group. Patient is pregnant or lactating.

3.1. Dosage of Rosecana The following is the dose to treat severe acne with Rosecana for each specific patient:
Dose for the elderly, adults and adolescents: Use the initial dose of 0.5mg/kg body weight/day, then adjust the dose and duration of use depending on the patient's medical condition. Most doctors recommend that patients should take Rosecana at a dose of 0.5-1mg/kg body weight/day. Dose for patients with severe renal impairment: Use a lower initial dose, then gradually increase to 1mg/kg body weight/day or as recommended by the physician. Dosage for children: Rosecana is not recommended for children under 12 years of age. Dose for Intolerance: If the patient cannot tolerate the drug at the recommended dose, a lower dose should be started. However, this can prolong treatment and lead to a higher risk of disease recurrence. 3.2. How to use Rosecana effectively Rosecana is in the form of a soft capsule, so patients can take it orally according to the dosage prescribed by a dermatologist. You can take Rosecana with meals and use it with a frequency of 1-2 times / day.
Before using Rosecana, you need to carefully read the instructions for use printed on the package or follow the instructions of your doctor. Avoid self-medicating, changing the dose or prolonging treatment without consulting your doctor.
3.3. Rosecana Overdose Treatment Rosecana overdose can cause symptoms similar to vitamin A overdose, including:
Nausea or vomiting. Severe headache. Irritation and itching. Chicken sleep. In fact, these Rosecana overdose symptoms usually subside on their own after a period of time without the need for treatment.

In certain cases, patients may experience unwanted side effects when treating acne with Rosecana. Most of these symptoms disappear after the dose is reduced or the drug is stopped. However, some side effects tend to persist even after the patient has stopped treatment.
According to reports, the most common symptoms that patients experience after using Rosecana, include:
Dry mucous membranes of the lips or nose. Lip inflammation. Eye conjunctivitis. Epistaxis . Dry skin. In addition, patients may also have some other symptoms as follows:
Common side effects: Increased erythrocyte sedimentation rate, anemia, neutropenia, thrombocytopenia, eyelid inflammation, pain headache, dry eyes, conjunctivitis, eye irritation, dry nose, epistaxis, rhinitis, cheilitis, increased transaminases, dry, scaly skin, dermatitis, back pain, arthralgia, hyperlipidemia, hypertriglyceridemia , hyperglycemia, hypercholesterolemia, proteinuria or blood. Uncommon side effects: Anaphylaxis, skin allergies, mood swings, asthenia or rash. Rare side effects: Diabetes, lymphadenopathy, psychosis, hyperuricemia, benign intracranial hypertension, suicidal ideation, convulsions, cataracts, blurred vision, intolerance contact lens loading, color blindness, photophobia, decreased night vision, vasculitis, hearing loss, enteritis, bronchial asthma, gastrointestinal bleeding, dry mouth, hepatitis, pancreatitis, nausea , alopecia, acne flare-ups, increased sweating, hyperpigmentation, increased creatine phosphokinase or glomerulonephritis. You need to tell your doctor right away if you experience the unwanted side effects mentioned above when using Rosecana medicine.

Here are some notes that patients need to take precautions during treatment with Rosecana:
Rosecana has a teratogenic risk, so patients need to apply birth control measures during treatment. treat. Avoid donating blood while taking Rosecana and about 1 month after stopping treatment because the active ingredient isotretinoin can be dangerous for pregnant women receiving blood. Increased acne growth during the first period of treatment, but will gradually decrease after that (usually about 7-10 days). When using Rosecana, it is important to avoid exposure to UV rays or strong light from the sun. Ideally, patients should use sunscreen with an SPF of 15 or higher. For 5-6 months after treatment with Rosecana, patients should avoid laser skin treatments or corrosive chemicals as this may increase the risk of skin pigmentation disorders or keloids in the treated area. . Avoid waxing for 6 months after using Rosecana to prevent the risk of skin peeling. Do not use Rosecana together with other topical products that have a keratinolytic or scaly effect to prevent the risk of skin irritation. Ointment or moisturizing cream should be applied to the skin and lips from the very beginning of treatment with Rosecana. Check liver enzymes before using Rosecana, every 3 months during treatment and 1 month after treatment ends. If there are signs of increased liver enzymes, consider reducing the dose or stopping the drug. Check blood lipids before, during and after treatment with Rosecana. If the blood lipid level is abnormally high or there are symptoms of pancreatitis, the patient should stop taking the drug immediately. Rosecana should be stopped if the patient shows signs of severe diarrhea or has a hereditary intolerance to fructose. Perform pre-treatment screening for patients with obesity, diabetes, dyslipidemia, or alcohol abuse.

Patients should avoid vitamin A supplements during treatment with Rosecana to prevent the risk of life-threatening poisoning. In addition, when using any other medicine, herb or dietary supplement, patients should also inform their doctor before taking Rosecana.
In summary, Rosecana is a prescription drug for the treatment of severe acne. To ensure safety for health and maximize the effectiveness of treatment, patients should not use it on their own, but need to consult a doctor before using it.