Using Vastarel to treat coronary artery disease, myocardial ischemia, what should be noted?

The article is professionally consulted by Master, Doctor Nguyen Minh Son - Interventional Cardiologist - Department of Medical Examination & Internal Medicine - Vinmec Nha Trang International General Hospital

Vastarel is a new generation angina treatment drug, effective for patients with coronary ischemia. Mechanism of action of Vastarel helps the heart muscle to switch from using energy from fat to using energy from glucose, helping the heart muscle to consume less oxygen and energy, preventing angina pectoris. From the mechanism of action, Vastarel is only highly effective for stable angina attacks. The drug is not effective in people with acute myocardial infarction or unstable angina pectoris.

Vastarel is not the first drug to treat angina due to myocardial ischemia, the drug is used after vasodilator groups such as nitrates, can be combined with nitrates to increase the effectiveness of pain control while reducing the effects. side effects for this group; Vastarel is only recommended to use the drug within 3 months due to the unwanted effects of the drug, it is necessary to consult a doctor about the time of taking the drug; If you still feel chest pain or increased chest pain while using Vastarel, you should seek medical attention immediately. The cause may be due to ineffective use of drugs or manifestations of acute myocardial infarction; Do not arbitrarily stop the drug because it can make angina angina worse, so consult your doctor before stopping using Vastarel; Vastarel should be used with caution for subjects such as: + Pregnant and lactating women. Although there are still not enough studies to determine the risks of taking this medicine during pregnancy or breast-feeding. Before taking medication, always consult with your doctor to weigh the benefits and risks.
+ Vastarel (Trimetazidine) can increase hand tremors in people with Parkinson's disease, increase seizures in people with epilepsy. Therefore, the use of the drug in these patients must be especially cautious.
+ The special subjects that need to be noted when using are patients over 75 years old or patients with moderate renal failure and do not use Vastarel with people with severe renal impairment.

On the market today, there are 2 main types of Vastarel, Vastarel 20mg and Vastarel 35mg. The 20mg tablet is usually the rapid-release form, while the 35mg is the long-acting (MR) form. The effects of these two types will be the same. However, the duration of action, dosage, and usage of each drug will be different, so patients should not arbitrarily buy drugs to use or change between these two dosage forms without guidance from a doctor. Patients should use the drug with a meal or immediately after a meal to increase the effectiveness of treatment, reduce the side effects of the drug on the gastrointestinal tract, do not chew the drug, but should take the whole tablet for prolonged release form. . Dosage: With Vastarel 20mg, the drug is usually taken 3 times a day. As for the 35mg content, it will be taken orally twice a day, each time 12 hours apart. If you forget to take Vastarel, take it as soon as you remember. If it is too close to the time for your next dose, skip the missed dose and take it as usual. Possible undesirable effects: + The most common are dizziness, headache, gastrointestinal disorders (abdominal pain, diarrhea, dyspepsia, vomiting), rash, itching, urticaria.
+ More rarely, a small number of patients taking the drug may have heart palpitations, palpitations, sleep disturbances, hand tremors, muscle stiffness, difficulty speaking.... If these signs appear, you You should notify your doctor for prompt treatment.

+ Lower blood pressure: Be careful and careful when using this drug with antihypertensive drugs to avoid a drop in blood pressure.
+ Nervous system dysfunction: causing dizziness, headache, drowsiness, so you should limit driving or using machines if you see these abnormal signs.
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