Uses of Homan

Homan medicine has the main ingredient ursodeoxycholic acid with the use of treating primary cholestatic cirrhosis and dissolving cholesterol gallstones. The following article would like to send readers detailed information about Homan drug line.

Homan drug is used in the following cases:
Treatment of primary biliary cirrhosis. Dissolution of small to moderate inoperable cholesterol gallstones (without X-ray blocking) in patients with normal gallbladder function. Ursodeoxycholic acid does not dissolve calcium-coated cholesterol stones or bile pigment stones. Homan medicine is not used in the following cases:
Patients with hypersensitivity to ursodeoxycholic acid or to any of its ingredients. Calcium stones with X-ray interference. The patient has acute cholecystitis and bile duct inflammation. Patients with biliary obstruction include obstruction of the common bile duct or a cystic duct. Patients often experience pain due to gallstones. Decreased contractile function of the gallbladder. Pregnant and lactating women. Patients with chronic liver disease, inflammation of the small intestine or colon, peptic ulcer.

2.1. How to use Homan medicine is in the form of tablets and is taken orally. Should take Homan medicine with food, during meals so that the drug can promote the best treatment effect.
Patients should use the medicine with boiled and cooled water, filtered water with enough volume depending on each person's needs.
In the process of using Homan medicine, you should strictly follow the instructions or instructions of your doctor or pharmacist. Avoid abruptly stopping or changing the dose of Homan without consulting a qualified medical professional.
3.2. Dosage Homan drug dosage for adults and the elderly refer to the following:
Primary cholestatic cirrhosis: The recommended dose is 10-15 mg of ursodeoxycholic acid/kg/day, divided into 2-4 times. Gallstone dissolution: The recommended dose is 6-12 mg of ursodeoxycholic acid/kg/day, taken once before bedtime or in 2-3 divided doses (increase by 15 mg ursodeoxycholic acid/kg/day in obese patients, if need). Treatment time for ursodeoxycholic acid can be up to 2 years depending on the size of the stone. In case the stone has dissolved, it is recommended to continue taking ursodeoxycholic acid for another 3 months. In case of overdose of ursodeoxycholic acid, patients may experience diarrhea. In general, other ursodeoxycholic acid overdose symptoms do not occur because their absorption decreases with increasing dose and Homan drug is excreted in the feces more. Therefore, when an overdose of Homan drug does not need to use special treatment measures, if the patient occurs diarrhea, it is necessary to rehydrate and balance electrolytes.
If the patient forgets a dose of Homan, take it as soon as possible after remembering. However, if the make up dose is close to the next dose, skip the make up dose and take your next dose at the scheduled time. Note that a double dose of Homan medication should not be taken.

The following are some of the reported Homan drug interactions as follows:
Co-administration of Homan with activated charcoal, Colestyramine, Colestipol, antacids containing aluminum hydroxide and Smectite (aluminum oxide) binds ursodeoxycholic acid in the intestines. thus inhibiting the absorption and efficacy of Homan drugs. In case of need to use, it is necessary to take the above drugs at least 2 hours before or after taking ursodeoxycholic acid. The ursodeoxycholic acid contained in the drug may reduce the absorption of ciprofloxacin, increase the absorption of cyclosporin from the intestine, reduce the peak plasma concentration and AUC of the calcium antagonist nitrendipine, and reduce the therapeutic effect of dapsone. Patients being treated with Cyclosporin when used in combination with Homan should check the concentration of Cyclosporin in the blood and adjust the dose if necessary. Drugs that lower blood cholesterol (such as clofibrat), oral contraceptives, and oestrogens, can increase gallstones, having the opposite effect of the ursodeoxycholic acid used to dissolve gallstones. In some cases, the use of Homan may reduce the absorption of Ciprofloxacin. Ursodeoxycholic acid has been shown to reduce the peak plasma concentrations (Cmax) and area under the curve (AUC) of the calcium antagonist nitrendipine. Homan reduces the therapeutic effect of dapsone has also been reported.

During the use of Homan medicine, patients may experience unwanted side effects such as:
Digestive disorders: Nausea & vomiting, diarrhea, abdominal discomfort, abdominal pain, constipation, indigestion. Hepatobiliary disorders: Jaundice, calcification of gallstones (rare) render them insoluble by bile acid therapy and require surgery. Laboratory Abnormalities: ALT & AST elevation, blood alkaline phosphatase elevation, blood bilirubin elevation, -GT elevation, liver enzyme elevation, abnormal liver function test, transaminase elevation. Skin and soft tissue disorders: Urticaria, rash, pruritus, alopecia. Body as a whole: Fatigue, fever, peripheral edema. Immune system disorders: Hypersensitivity reactions, facial edema, urticaria, angioedema, laryngeal edema. Musculoskeletal and connective tissue disorders: Myalgia. Nervous system: Dizziness, headache. Respiratory disorders: Cough. When the patient experiences any side effects of Homan medicine, it is necessary to stop using it and notify the doctor / pharmacist or go to the nearest medical center for timely treatment.

Patients need to carefully refer to the information on using Homan medicine listed on the product packaging or strictly follow the instructions of the doctor, pharmacist. In addition, you can refer to the following contents:
While using Homan medicine, patients need to be monitored for liver function parameters during the first 3 months of treatment. After 6 to 10 months of treatment with Homan, the patient needs to take an X-ray of the gallbladder to assess the progress of treatment and promptly determine the calcification of gallstones. If the process of using Homan has diarrhea: The patient needs to reduce the dose and if he has had diarrhea before, he should not use the drug. Patients with galactose intolerance, glucose-galactose malabsorption, Lapp lactose deficiency should not use Homan. The safety and efficacy of Homan in children have not been established. During the first 3 months of treatment with Homan, liver function parameters such as AST, ALT and -GT should be monitored every 4 weeks, then every 3 months. In addition to determining the response or non-responder in patients treated for primary biliary cirrhosis, monitoring also helps detect the risk of liver failure early, especially in patients with advanced stages of liver disease. primary biliary cirrhosis. During the use of Homan drug to treat advanced stages of primary biliary cirrhosis, it is very rare that decompensated cirrhosis occurs and the patient must stop taking the drug. It is not known that Homan affects the ability to drive and use machines. During pregnancy when taking Homan, there are not enough data on the use of ursodeoxycholic acid in pregnant women, especially in the first trimester of pregnancy. Animal studies using ursodeoxycholic acid have shown evidence of teratogenic effects in early pregnancy. Therefore, the use of ursodeoxycholic acid in pregnant women is not recommended. The drug should be discontinued immediately if pregnancy is detected and should consult a doctor. Women of childbearing potential should only be treated with Homan when using effective contraception. It is important to ensure that you are not pregnant before starting treatment with the drug. Lactation: There are no specific data on whether ursodeoxycholic acid passes into breast milk. Therefore, do not use Homan in nursing women. If treatment with Homan is necessary, breast-feeding should be discontinued.