Does ROMA index 37.32% have ovarian cancer?

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Hello doctor. Immunoassay: AFP 4.27 / CA.125 84.5 /HE4 63.9/ ROMA VALUE 37.32. Doctor, can I have ovarian cancer with the above test results? Looking forward to receiving your doctor's reply, thank you.
Do Ngoc Y (1979)
Reply
Hello sister! The normal CA 125 cancer antigen is found in the endometrium, in uterine fluid, in some normal tissues, and on the surface of many ovarian cancer cells. Elevated CA 125 levels can be seen in:
Ovarian tumors of epithelial origin, benign gynecological diseases (ovarian cysts and endometriosis), malignancies (endometrium, breast, gastrointestinal tract), other diseases (pancreatitis, cirrhosis, hepatitis, benign gastrointestinal diseases, kidney failure), pregnancy.
HE4 (Human epididymal protein 4) is found mainly in the female reproductive tissues, epididymis, and vas deferens in the male reproductive system, and is also found in the epithelium of the respiratory tract, distal renal tubules, salivary glands, and mucous membranes. colonic mucosa with variable concentrations. HE4 is a highly sensitive cancer marker for ovarian cancer especially in stage I disease.
ROMA index: A combination of two tests CA125, HE4 and the patient's menstrual status is used to assess the risk of ovarian cancer in women presenting with pelvic tumors. Depending on the test method and menstrual status, the cutoff point will vary. At Vinmec hospital, these two tests were performed on Roche's Cobas system with the following cut-off points:
1. Premenstrual (menstrual)
ROMA < 11.4% Low Risk ≥ 11.4% High Risk 2 . ovarian cancer if there is a pelvic tumor. However, it is an indicator to assess the risk of ovarian cancer in women presenting with pelvic mass, but has no definitive diagnostic significance. To make a definitive diagnosis, it is necessary to combine clinical symptoms, subclinical symptoms, imaging tests, ... and be concluded by an oncologist. Wish you always healthy!
Thank you for your question to Vinmec Health System. Best regards!

Doctor Tran Thi Huyen Trang - Laboratory Doctor - Laboratory Department - Vinmec Times City International Hospital