Quantitative results of TSH and Uric Acid increase, what disease warning?

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Hello doctor! I have had a blood test and the result of TSH is 5.77, normal reading is 0.23-4.0mU/L. Uric acid quantification is 509.55/normal index 238-476 umo/l. So the doctor asked me: "The quantitative results of TSH and Uric Acid increase, what disease warning?". Thanks for the advice doctor!
Vu Dinh Thanh (1967)
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Hello!
TSH (Thyroid Stimulating Hormone) is secreted by the anterior pituitary gland under the control of a hormone of the hypothalamus = (TRH). When thyroid hormone levels in the circulation drop or when the body is faced with physical or mental stress, the hypothalamus is stimulated to release hormones that cause the release of thyroid-stimulating hormone (TRH). TRH stimulates the anterior pituitary to produce thyroid-stimulating hormone (TSH). TSH then stimulates the production and release of Triiodothyronine (T3) and Thyroxin (T4).
TSH is a very valuable test in the diagnosis and monitoring of thyroid disease, especially in Basedow's disease.
The main purpose of the TSH test is to see if the thyroid gland is functioning as it should, and is very useful in early diagnosis of thyroid dysfunction diseases (hyperthyroidism and hypothyroidism) and the underlying cause. the root of the disorder, from which there are timely and early treatment counseling directions to bring better quality of life.
Elevated TSH is common in the following cases:
Primary hypothyroidism (in the thyroid gland) Anti-TSH antibodies or anti-thyroid hormone status After proximal or total thyroidectomy Hyperthyroidism of glandular origin Yen Ectopic TSH production Hashimoto's thyroiditis...

In your case, it is necessary to be examined by a specialist and do other tests to determine the cause of the increase in TSH and have a reasonable treatment plan.
Uric acid is a product of purine degradation of nucleic acids. The main sources of uric acid in the body include: Foods and drinks rich in purines such as animal organs, seafood, fish, meat, beer, wine,... Accordingly, the cells in the body When it ages, dies, its purine nucleus is destroyed and forms uric acid, this is called endogenous source of uric acid.
Uric acid is synthesized in the liver, excreted from the body 80% via urine and 20% through the digestive tract. If the process of synthesis and excretion of uric acid occurs in balance, the amount of uric acid in the blood will be within normal limits. If the amount of uric acid formed is high or the elimination capacity of the kidneys is reduced, the amount of uric acid in the blood will increase and be deposited in the tissues. When uric acid is deposited in the joints, it can cause gout, a metabolic disorder characterized by intense pain and swelling in the joints. If uric acid is deposited in the kidney, it can cause kidney stones. If it is deposited in the heart, it will cause cardiovascular disease,...
Uric acid test is done to diagnose diseases that cause changes in uric acid levels in the body. . Doctors appoint uric acid test to diagnose gout when the patient has appropriate clinical symptoms. Blood uric acid testing is also performed periodically to monitor gout patients during treatment.
In your case, uric acid levels in the blood are high, but if clinical symptoms have not yet appeared, acute gout attacks, this stage is often called "hyperuricemia", not gout. However, when the amount of uric acid in the blood is elevated for a long time, urate crystals will be deposited in the joints, causing acute attacks of arthritis, also known as acute gout attacks. At that time, hyperuricemia has progressed to gout.
Hopefully, the doctor's sharing will help you answer the question: "The quantitative results of TSH and Uric Acid increase, what disease warning?". If you need more in-depth consultation, you can go to a hospital of Vinmec Health System to be examined and consulted by specialist doctors on further treatment methods.
Thank you for trusting and sending questions to Vinmec. Best regards!
Answered by Doctor Tran Thi Huyen Trang - Laboratory Doctor - Laboratory Department - Vinmec Times City International Hospital