An overview of platelet-rich plasma and its applications

Posted by MSc. Nguyen Dac Tu, Product Quality Evaluation Team Leader, High Technology Center, Vinmec International General Hospital.

Platelet rich plasma or PRP (Platelet rich plasma) is an autologous product with a platelet content many times higher than the average platelet count in the peripheral blood. Platelet-rich plasma contains a large amount of growth factors and cytokines with many important roles in wound regeneration and healing.

Many studies at the level of in vitro, in vivo and in clinical practice have shown that the application of PRP brings many high efficiency in two areas of damage and cosmetic treatment. With a simple and convenient implementation process, great potential for clinical application, safety and effectiveness, PRP has gradually become a widely used treatment. Platelet-rich plasma (PRP) is also known under terms such as: autologous platelet gel, plasma rich in growth factors (PRGF), platelet- rich fibrin (PRF), platelet concentrate (PC) is a plasma solution isolated from autologous blood that has a platelet count 3-7 times higher than that of peripheral blood. PRP contains a large amount of proteins such as PDGF, TGF-β, PF4, IL-1, PDAF, VEGF, EGF, PDEGF, ECGF, IGF, osteocalcin, osteonectin, fibrinogen, vitronectin, fibronectin and thrombospondin. These are growth factors, cytokines and chemokines that play an important role in wound healing and tissue regeneration through the attraction of cells such as macrophages, neutrophils, fibroblasts, mesenchymal stem cells, bone-forming cells (osteoblasts) to rebuild damaged tissue.

PRP is currently being applied in many different fields such as: musculoskeletal-musculoskeletal injuries in sports or due to aging, cardiovascular surgery, cosmetology, dentistry, obstetrics-gynecology, dermatology, and eye surgery. department. Recently, PRP is also widely used in the field of dermatology and cosmetology such as: tissue regeneration, wound healing, scar fading, skin rejuvenation, hair loss treatment, obstetrics, fertility support. In addition to the therapeutic effect, PRP is isolated from autologous blood, so it is also very safe because it limits the risk of transmitting diseases such as HIV, hepatitis, and immune response.

Currently, the High-Tech Center, Vinmec Times City Hospital is providing platelet-rich plasma products for the treatment of injuries to muscles, tendons, ligaments, joints and skin aesthetics such as facial rejuvenation. , the body skin puddles as well as anti-aging skin. PRP products at Vinmec are prepared in a clean room system that meets international standards ISO 14644-1, the preparation process uses modern machinery and is manufactured according to ISO 13485 process. Orthopedic Trader. Musculoskeletal and Aesthetics of Vinmec are experts in the field of using platelet-rich plasma when they have treated nearly 1000 customers in the two years 2018-2019. With the above reasons, it can be affirmed that the platelet-rich plasma product provided by Vinmec Times City Hospital is the safest and most effective product in Vietnam today.