Treatment options for stage III breast cancer

Stage 3 breast cancer means the cancer has spread to 4 to 9 axillary lymph nodes. These tumors will be any size. At this stage, it is necessary to have appropriate treatment methods to minimize the metastasis to distant parts of the body.

In stage 3, the cancer has spread beyond the breast and into nearby lymph nodes. Often, many lymph nodes have cancer cells or a tumor that is too large to grow into the chest wall or the skin of the breast.
Stage 3 breast cancer is divided into subtypes IIIA, IIIB, and IIIC.
Stage IIIA describes invasive breast cancer where:
No tumor is found inside the breast or the tumor is of any size. At this stage, cancer is found in 4 to 9 axillary lymph nodes or in the lymph nodes near the breastbone (the tumor is found on imaging tests or physical exam. The tumor is larger than 5cm. small groups of breast cancer cells (larger than 0.2mm but not larger than 2cm) found in lymph nodes Tumor larger than 5cm; cancer has spread in 1 and 3 axillary lymph nodes or to lymph nodes near the breastbone (found in a lymph node biopsy) However, if the cancerous tumor is larger than 5cm and is at grade 2, cancer is found in 4 to 9 lymph nodes in axillary, estrogen and progesterone receptor positive, HER2 positive then it would probably be classified as stage IB.

Stage IIIB describes invasive breast cancer where:
The tumor can be any size and has spread to the chest wall or skin of the breast causing swelling or ulceration. The tumor may have spread to up to 9 axillary lymph nodes. The tumor may have spread to lymph nodes near the breastbone. However, if the cancerous tumor measures more than 5cm and is at grade 3, cancer is found in 4 to 9 axillary lymph nodes, is estrogen and progesterone receptor positive, and HER2 positive, then it is likely to be diagnosed. classified as stage IIA.
Breast cancer is considered at least stage IIIB. Typical features of inflammatory breast cancer include: a red layer in the skin of the breast, the breast feels warm and may be swollen, and cancer cells have spread to the lymph nodes and can be found in the skin.
Stage IIIC describes invasive breast cancer where:
There are no signs of cancer in the breast or, if there is a tumor, it can be any size and can spread to the chest wall or skin of the breast Cancer cancer has spread to 10 or more axillary lymph nodes. Cancer has spread to lymph nodes above or below the collarbone Cancer has spread to lymph nodes in the armpit or to lymph nodes near the breastbone. However, if the aforementioned cancer is any measurable size and is grade 2, estrogen and progesterone receptor positive, HER2 positive or negative, it will probably be classified as staged. IIIA.

Chemotherapy: Chemotherapy is a common treatment for stage 3 breast cancer. Sometimes, in some patients, this treatment can be used before surgery to shrink the tumor and make it smaller. for it to be removed easily during surgery. It can also help kill any remaining cancer cells after surgery. In cases where surgery is not the treatment of choice, chemotherapy may be the mainstay of treatment.
Patients can access chemotherapy treatment in many different ways, such as taking drugs or liquids containing chemicals to carry out the treatment process. However, usually the specialist will administer the drug intravenously to the patient. Depending on the type of treatment, chemotherapy treatments may be built in cycles and allow the body to rest between treatments.
Surgery : Surgical methods can be applied when removing the tumor. The surgeon then removes the tumor and some surrounding tissue from the breast. Or you may need surgery to remove the entire breast as well as remove all the lymph nodes. After a mastectomy, the patient may choose to have breast reconstruction surgery.
Radiation therapy: Often used to treat women with stage III breast cancer after surgery. This treatment can kill cancer cells that may have been missed.
Hormone therapy: Hormone therapy can help women with hormone receptor-positive breast cancer. That means the cancer needs hormones to grow. In these women, medication can stop the tumor from taking up hormones. The drugs used in this procedure include tamoxifen (for all women) and the aromatase inhibitors anastrozole (Arimidex), exemestane (Aromasin) and letrozole (Femara) (for postmenopausal women). Fulvestrant (Faslodex) and toremifene (Fareston) are hormone receptors and are sometimes given to women with metastatic breast cancer.
Women who have not yet reached menopause may consider surgical removal of the ovaries to stop it from producing hormones that help cancer grow. Or medications can be used to stop the ovaries from releasing hormones.

Targeted Therapy: Targeted therapy is a new treatment. About 20% of women with breast cancer have too much of the HER2 protein, and it causes the cancer to spread quickly. Women with HER2-positive breast cancer may be prescribed drugs such as: adotrastuzumab emtansine (Kadcyla), famtrastuzumab deruxtecannxki (Enhertu), lapatinib (Tykerb), neratinib (Nerlynx), pertuzum. Or a CDK 4/6 inhibitor such as abemaciclib (Verzenio), palbociclib (Ibrance), or ribociclb (Kisqali) is sometimes used in postmenopausal women with certain types of advanced breast cancer. These drugs can block the HER2 protein from growing cancer and can make chemotherapy treatments more effective.
People who are HER2-negative but have BRCA-mutant breast cancer can be treated with a class of drugs called PARP inhibitors that target a protein that helps cancer cells grow. PARP inhibitors include: olaparib (Lynparza) and talazoparib (Talzenna). Everolimus (Afinitor) is a targeted therapy that is sometimes given to women with HER2-negative breast cancer along with exemestane (Aromasin) hormone therapy.
People with HER2-negative breast cancer but with metastatic or metastatic breast cancer PIK3CA can be treated with the novel PIK3 inhibitor, and alpelisib (Piqray) in combination with narcotics.
Immunotherapy : Using immunotherapy drugs that stimulate the patient's immune system to find and destroy cancer cells. In women with HER2-negative breast cancer, the immunotherapy drug atezolizumab (Tecentriq) can be used and is sometimes used in combination with chemotherapy paclitzxel (Abraxane). Or Atezolizumab blocks a protein called PD-L1.
Clinical Trials: A clinical trial will provide more opportunities for women with stage 3 breast cancer. A clinical trial can give patients and doctors access to treatments. New treatments such as new treatments-new drugs, or new treatments, new drugs combined with existing treatments are being tested in clinical trials.
Breast cancer is a common cancer in women, it is estimated that every year around the world, many women die from this disease. Accordingly, if breast cancer is detected early, the prognosis for treatment is very high, even if it is completely cured and not recurred. Therefore, breast cancer screening is essential, especially for those at high risk of breast cancer.
Currently, Vinmec International General Hospital has been implementing a breast cancer screening package for women of different ages. At Vinmec, there is a full range of necessary medical equipment, a system of modern medical machinery to perform methods of examination, diagnosis, testing, imaging, and treatment of breast cancer at many stages. . Accordingly, the breast cancer examination and treatment process at Vinmec is carried out by a team of highly qualified doctors and nurses who have undergone training and are technically certified, able to handle quickly and effectively. . Therefore, when using Vinmec's breast cancer screening and early detection package, customers can detect cancer even when there are no symptoms.
For detailed advice on breast cancer screening packages as well as effective treatment methods at Vinmec, please come directly to Vinmec health system nationwide or register online HERE .