Should I take endurance medicine when running?

Salk Institute scientists, building on previous work identifying gene sequences that are activated by running, and the discovery of this complete activation in sedentary mice by a chemical compound, mimics the beneficial effects of exercise, including increasing body fat burning and endurance. The study, which appeared in the journal Cell Metabolism on May 2, 2017, not only helps us deepen our understanding of aerobic endurance, but also provides those with heart disease, lung disease, type 2 diabetes.. . hope to achieve its pharmacological benefits.
Senior author Ronald Evans, Howard Hughes Medical Institute investigator and holder of the Salk's March of Dimes Chair in Molecular and Developmental Biology, said: “Everybody knows that people can Improve your endurance through exercise. But how does endurance work? And if we really understood the science, could we replace the training with a drug?
Develop endurance that can sustain aerobic activity for longer periods of time. As people get stronger, their muscles switch from burning carbohydrates (glucose) to burning fat. Therefore, the researchers hypothesized that endurance is a function of the body's increasing ability to burn fat, although the details of this process remain hazy. Previous Evans lab work on a delta PPAR gene (PPARD) offered intriguing clues: mice genetically engineered to permanently activate PPARD became capable long-distance runners resistance to weight gain and a high response to insulin - all physical qualities. The team found that a chemical compound called GW1516 (GW) similarly activated PPARDs, replicating the ability to control weight and respond to insulin in normal mice seen in normal mice. designed child. However, GW had no effect on endurance (how long mice could run) unless combined with daily exercise, which defeats the purpose of using it as a replacement for exercise.

In the current study, Salk's team gave normal rats a higher dose of GW, for a longer time (8 weeks instead of 4). Both the mice that received the compound and the mice that weren't regularly sedentary, were all tested on treadmills to see how long they could run until they were exhausted.
The mice in the control group could run for about 160 minutes before they were exhausted. However, the rats given the drug were able to run for about 270 minutes - about 70% longer. For both groups, exhaustion occurred when blood sugar (glucose) dropped to about 70 mg/dl, suggesting that low glucose levels (hypoglycemia) were to blame.
To understand what was happening at the molecular level, the team compared gene expression in a major muscle of mice. They found 975 genes whose expression changed in response to the drug, becoming either inhibited or increased. The genes with increased expression are those that regulate fat breakdown and burning. Surprisingly, the suppressed genes are involved in the breakdown of carbohydrates for energy. This means that the PPARD pathway prevents sugar from becoming an energy source for muscles during exercise, possibly to preserve sugar for the brain. Triggering fat burning takes longer than burning sugar, which is why the body typically uses glucose unless there's a compelling reason not to - like maintaining brain function during times of high energy expenditure. quantity. Although muscles can burn sugar or fat, the brain prefers sugar, which explains why endurance runners feel physically and mentally fatigued when they use up their sugar supply. grant.
Michael Downes, Salk senior scientist and co-author of the paper said: “This study shows that fat burning is not a driving force promoting endurance rather than a compensatory mechanism for preserving glucose.” . PPARDs are blocking all points involved in sugar metabolism in the muscle so that glucose can be redirected to the brain, thus preserving brain function.
Interestingly, the muscles of the rats given the exercise drug did not exhibit the kinds of physiological changes that normally accompany aerobic exercise: mitochondrial replenishment, more blood vessels, and a shift to type Muscle fibers burn fat instead of sugar. This suggests that these changes are not exclusive to increasing endurance; it can also be done by chemically activating the genetic sequence. In addition to increased endurance, the mice that were given the drug were also more resistant to weight gain and more responsive to insulin than the mice that weren't given the drug.
Exercise activates PPARD, but we show that you can do the same thing without mechanical training. That means you can improve endurance to the same level as a person working out without any physical exertion.

Although laboratory studies have been performed on mice, pharmaceutical companies are still interested in using this research to develop clinical trials for humans. The team can envision several therapeutic applications for a GW-based prescription drug, ranging from enhancing fat burning in people with obesity or type 2 diabetes to improving pre- and patient fitness. after surgery.
From these results, it is shown that the use of drugs to increase endurance when running requires many longitudinal studies with long study periods to have concrete evidence for this information.

In order to practice running effectively and maintain endurance during practice, you should apply some of the following contents:
Perform proper running technique: First before performing the exercise When running, you must do a warm-up, then start with the exercise at a slow pace and then gradually increase the speed. You should note that during the exercise do not hold anything. Proper breathing when running will help your body's endurance as well as maintain or increase running speed. Reasonable rest mode: Along with a reasonable rest during running, you should replenish minerals along with drinking water after running. Please regularly monitor Vinmec website (www.vinmec.com) to update useful health care information and leave information when you need medical advice and support!

Reference source: independent.co.uk