Uses of Tafasitamab-cxix (Monjuvi)

Tafasitamab-cxix or Monjuvi is a prescription medicine for the treatment of diffuse large B-cell lymphoma (DLBCL), a type of non-hodgkin lymphoma. Tafasitamab-cxix should only be used as ordered and directed by your doctor. Do not arbitrarily use to avoid encountering risks.

Tafasitamab-cxix (monjuvi) is considered a modified monoclonal antibody that binds to the CD19 antigen present on the surface of B lymphocytes. These monoclonal antibodies have been studied and engineered to bind to targets found on specific types of cancer cells. The antibody stimulates the immune system to attack the cell it is attached to, resulting in the immune system killing the cells. These antibodies can work in a variety of ways, including stimulating the immune system to kill cells, stopping the growth of cancer cells, or other functions necessary for growth. of this cell. Thus, Tafasitamab-cxix (monjuvi) is an antibody against the CD19 protein. From there, it will help the body stop or slow down the growth of cancer cells.

Monjuvi is usually absorbed into the body through intravenous injection. Dosage is based on the patient's weight and the frequency of use will depend on the disease condition and the body's response. The length of treatment will depend on whether the patient has any reactions or side effects to Monjuvi. The patient may be given medication before the infusion to prevent a possible reaction.

There are a few things to look out for in order to manage the possible side effects of Tafasitamab-cxix. The patient should talk to the treating doctor to help you come up with the most appropriate treatment. The following are some of the most common reactions to monjuvi:
Infection due to a decrease in white blood cell count (leukopenia or neutropenia) During treatment with Monjuvi, the number of The user's white blood cells may be reduced, putting the body at a higher risk of infection. Call your doctor right away if you have a fever (temperature above 38°C), sore throat or cold, trouble breathing, cough or burning when urinating, or notice a wound that's taking a long time to heal.
Decrease in platelet count Platelets play a role in hemostasis, so when the platelet count is lower than normal, the patient is at a higher risk of bleeding. Tell your doctor if you notice any excessive bruising or bleeding on your body. These include: nosebleeds, bleeding gums, or blood in the urine or stools. In cases where the platelet count becomes too low, a platelet transfusion may be indicated.
Do not use a regular razor to avoid bleeding. Avoid sports and vigorous activity where contact can cause injury or bleeding. Do not take aspirin (salicylic acid), steroids or anti-inflammatory drugs (NSAIDs) such as Motrin or Advil (ibuprofen), Aleve (naproxen), Celebrex (celecoxib)... as they can all increase the risk of bleeding. Tell your doctor about using these and all other over-the-counter supplements during treatment with Monjuvi. Limit flossing or using toothpicks because it can cause bleeding gums. Use a soft-bristled toothbrush instead. Anemia due to a decrease in the number of red blood cells During treatment with Monjuvi, the patient's red blood cell count is often reduced. The person may feel tired or weak. At this point, call your doctor if you feel short of breath or have chest pain. If the red blood cell count is too low, the doctor may give the patient a blood transfusion.
Diarrhea If this condition is encountered, the prescribing doctor will prescribe more medicines to the patient to prevent diarrhea. Alternatively, you can also try eating foods that are low in fiber, and foods that are unseasoned or low, such as white rice. Limit your intake of fruits, vegetables, wholegrain breads, cereals and seeds. Soluble fiber is found in some foods and absorbs fluids, which can help reduce diarrhea. Foods high in soluble fiber include: apple juice, bananas (ripe), canned fruit, oranges, boiled potatoes, white rice, white flour products, oatmeal, and chips.
Peripheral edema Peripheral edema is swelling of the extremities due to fluid retention. There may be swelling of the hands, arms, legs, ankles and feet. The edema site can become uncomfortable. Notify your doctor if you are experiencing any swelling on your body.
Fatigue Fatigue is very common during treatment with Monjuvi. Patients often have a feeling of exhaustion that does not go away even with rest. Take time to rest during the day and save energy for other more important activities. Exercise can be a hint to help reduce fatigue, a simple daily walk can make the body stronger.
Reduce appetite or change appetite Nutrition is a very important part of the treatment of disease. Using Tafasitamab-cxix may affect a person's appetite. In some cases, the side effects of treatment with Monjuvi can make it difficult to eat and drink. Get nutritional advice from your doctor to help you choose the right foods.
Break up your meals throughout the day into several small meals, eating five or six small meals or snacks throughout the day, instead of 3 large meals a day. Do not eat any food that you find smells or tastes bad. If you have a problem with red meat, eat chicken, eggs, dairy products, and fish. Sometimes cold foods have less of an odor.

Using Monjuvi during pregnancy can cause harm or birth defects to the unborn baby. Therefore, patients should not become pregnant or become a father while taking Mnjuvi. During treatment, effective birth control is essential and for at least 3 months after the end of treatment with this medicine. Patients should also not breast-feed while taking Monjuvi or for 3 months after the last dose. Tafasitamab-cxix is ​​often combined with lenalidomide, so if both men and women are taking this medicine, use effective birth control.
In short, compliance with the correct use of Monjuvi is essential. Patients should follow the doctor's instructions for the drug to have good results with the body as well as avoid unwanted effects when used.