Glecaprevir-Pibrentasvir: Uses, indications and precautions when using

Glecaprevir-Pibrentasvir is a combination medicine with 2 active ingredients that helps to treat chronic hepatitis C. This is a very dangerous viral infection of the liver that, if not treated early, can lead to complications of cirrhosis, liver failure or liver cancer.

Chronic hepatitis C infection can cause serious liver problems such as scarring of the liver ( cirrhosis ) or liver cancer . Glecaprevir-Pibrentasvir is a combination of Glecaprevir and Pibrentasvir for the treatment of chronic hepatitis C. The drug's 2 active ingredients work by reducing the amount of hepatitis C virus in the body, helping the immune system fight infection and gradually rebuilding the liver.
It is not yet clear whether Glecaprevir-Pibrentasvir can help prevent virus transmission from sick people to healthy people. Therefore, patients should pay attention not to share needles and maintain safe sex (using condoms) to reduce the risk of infecting others.

Glecaprevir-Pibrentasvir is a prescription medication to be taken by mouth and with food as directed by your doctor, usually once daily. For the best effect, take Glecaprevir-Pibrentasvir at equally spaced times. You can keep it in mind by setting a schedule to take your pills at the same time each day. The length of Glecaprevir-Pibrentasvir treatment is based on the extent of your hepatitis and the effectiveness of other treatments you may have used in the past. Keep taking Glecaprevir-Pibrentasvir for the full time prescribed, even if symptoms disappear after a short time. Stopping the medication too soon can cause the liver infection to return.

Like many other drugs, Glecaprevir-Pibrentasvir can also bring some side effects such as: Fatigue, headache or nausea. Cases of allergy to Glecaprevir-Pibrentasvir are also rare. However, if you notice signs of a serious allergic reaction such as: rash, severe dizziness, itching and swelling of the face, tongue, throat, difficulty breathing, etc., seek medical help as soon as possible. .

Before taking Glecaprevir-Pibrentasvir, be aware of the following:
If you are allergic to Glecaprevir and Pibrentasvir or have any other condition, tell your doctor immediately; You should talk to your doctor about your medical history, especially other liver problems (such as hepatitis B, liver cancer), alcohol abuse or addiction, HIV infection, diabetes. If you have diabetes, your blood sugar may be lower during combined hepatitis C treatment. To avoid increasing your risk of low blood sugar, your doctor may consider adjusting your diabetes treatment plan. Tell your doctor if you have symptoms of low blood sugar such as: sudden sweating, shaking, fast heartbeat, hunger, dizziness, blurred vision or tingling in the hands or feet. During pregnancy, Glecaprevir-Pibrentasvir should only be used when clearly needed. Discuss the benefits and risks of medication with your doctor. It is not known whether Glecaprevir-Pibrentasvir passes into breast milk. If you are taking medication, consult your doctor before breast-feeding.

Glecaprevir-Pibrentasvir might slow the way other medicines are removed from your body, which in turn affects how they work. Examples of drugs that are affected include: Atorvastatin, Lovastatin, Simvastatin... In contrast, there are also some drugs that can affect the way Glecaprevir-Pibrentasvir is eliminated from your body, which may affect the effectiveness of the drug. Some drugs can include: Cyclosporin, Efavirenz, some drugs to treat seizures (such as Carbamazepine, Phenytoin), HIV protease inhibitors (such as Atazanavir, Darunavir), Rifampin... use.

Overdose: If Glecaprevir-Pibrentasvir overdose and symptoms such as fainting or difficulty breathing, the patient should be taken to the emergency room immediately. Do not take Glecaprevir-Pibrentasvir with other medicines. In addition, patients are encouraged to perform periodic health examinations, including medical tests such as liver function assessment, hepatitis B and C tests, etc. to monitor side effects (if any). ). Missed dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your usual dosing schedule. Storage: Store Glecaprevir-Pibrentasvir at room temperature, away from light and moisture. Avoid storing Glecaprevir-Pibrentasvir in the bathroom and keep it out of the reach of children and pets.

Reference source: Webmd.com