Hysingla ER: Uses, indications and precautions when using

Hysingla ER is used to help relieve ongoing severe pain. Hydrocodone belongs to the class of opioid pain relievers, it works in the brain to change the way your body perceives and responds to pain. Do not use extended-release hydrocodone for mild pain that will clear up in a few days. Hysingla is not used regularly.

Hysingla is indicated in the following cases:
Severe chronic pain requiring long-term opioid therapy Severe chronic pain with opioid tolerance Hysingla drug is contraindicated in the following cases:
Systemic leukocytosis A brain tumor A condition where thyroid hormone levels are reduced but left untreated. A condition in which the adrenal glands produce less hormone is called Addison's disease. Dehydration Mental disorder caused by sudden withdrawal of alcohol. Psychiatric disorders Mood swings Suicidal thoughts Drunk drug abuse Cor pulmonale Slow heart rate Abnormal heartbeat Low blood pressure Emphysema Decreased lung function Stomach or intestinal activity Ulcerative colitis Disease enteritis Constipation Liver disease Gallbladder disease Constriction of the bile duct Decreased kidney function Narrowing of the tube that carries urine out of the bladder Prostate enlargement Coma Convulsions Sleep apnea Shock Unrelenting urination Weak patient Pressure high pressure in the skull Severe abdominal pain Inherited autonomic dysfunction Obesity worsening asthma Worsening chronic obstructive pulmonary disease History of opioid overdose

Read the medication instructions provided by your doctor carefully before you start taking Hysingla ER and each time you get a refill. If you have any questions about how to use Hysingla, ask your doctor. Take Hysingla on a regular schedule as directed by your doctor, not to treat sudden pain. Hysingla is taken by mouth as directed by your doctor, usually once daily (24 hours apart). Do not soak, lick, or wet the tablet before you put it in your mouth as this may make it harder for you to swallow the tablet. If your Hysingla dose is more than one tablet, you should take one at a time. Take each tablet with enough water to make sure you swallow it completely as soon as you put it in your mouth. Do not crush or chew Hysingla extended-release tablets. Doing so may release all of the Hysingla medication at once, increasing the risk of side effects. Also do not split the tablets unless they have an index line and your doctor tells you to do so. You can take Hysingla with or without food. If you have nausea, it may be more helpful to take this medication with food. Ask your doctor about other ways to relieve nausea (such as lying down for 1 to 2 hours with as little head movement as possible). The dosage of Hysingla is given by your doctor based on your medical condition and response to treatment. Do not increase your dose or use Hysingla more often or for longer than prescribed. That doesn't help your condition improve any faster, it also increases your risk of side effects. Stop Hysingla properly when directed by your doctor. Hysingla pain relievers are most effective if used when the first signs of pain appear. Before you start using Hysingla, ask your doctor or pharmacist if you should stop or change the way you use your other opioid drug(s). Other pain relievers such as acetaminophen and ibuprofen may also be prescribed. Ask your doctor about safely using Hysingla with other medicines. Stopping Hysingla ER suddenly can cause withdrawal, especially if you have been using it for a long time or in high doses. To prevent withdrawal, your doctor may reduce your dose of Hysingla ER slowly. Tell your doctor right away if you have any withdrawal symptoms such as restlessness, mental/mood changes (including anxiety, trouble sleeping, suicidal thoughts), watery eyes. , runny nose, nausea, diarrhea, sweating, muscle pain, or a sudden change in behavior.

When Hysingla ER is used for a long time, it may not work, tell your doctor if that happens. Although Hysingla ER is helpful for many people, it can sometimes be addictive. Hysingla's addiction risk may be higher if you have a stimulant use disorder (such as drug/alcohol abuse or addiction). Tell your doctor if your pain does not improve or if it gets worse after using Hysingla.

While using Hysingla ER, you may experience nausea, vomiting, constipation, lightheadedness, dizziness, or drowsiness. Some of these side effects may decrease after you use Hysingla for a while. If any of these side effects persist or get worse, tell your doctor right away.
To prevent constipation while using Hysingla, you should eat a lot of fiber, drink enough water and exercise. And sometimes you may need to take a laxative.
To reduce the risk of dizziness and lightheadedness when using Hysingla ER, get up slowly when getting up from a sitting or lying position.
Remember that your doctor has prescribed Hysingla ER because they have judged that the benefit to you outweighs the risk of side effects. Many people use this medication and have no serious side effects.
Tell your doctor right away if you have any serious side effects of Hysingla ER, including: interrupted breathing during sleep (sleep apnea), mental/mood changes (such as agitation, confusion, hallucinations), stomach/abdominal pain, difficulty urinating, signs of an underactive adrenal gland (such as loss of appetite, unusual tiredness, weight loss).
Get medical help right away if you have any very serious side effects of Hysingla ER, including: Fainting, fast/irregular heartbeat, severe dizziness, seizures, slow breathing/ shallow, severe drowsiness/difficulty waking up.
A very serious allergic reaction to Hysingla ER is very rare. However, if you notice any symptoms of a serious allergic reaction to Hysingla, including: rash, itching/swelling (especially of the face/tongue/throat), dizziness, trouble breathing , get medical help right away.
Below are Hysingla ER side effects by likelihood.
Common side effects of Hysingla ER include:
Low blood pressure Constipation Drowsiness Creates a relaxed state easily Fainting Dizziness Nausea A feeling of discomfort Uncommon side effects Hysingla includes:
Bradycardia Vocal cord swelling Laryngeal constriction Pulmonary collapse Decreased lung function Bronchospasm Shortness of breath Abnormal nervous system function affecting alertness. Angioedema Heart palpitations Mood swings Unusual happiness Dependence on drugs Double vision Blurred vision Changes in vision Common cold Dry mouth Gastroesophageal reflux disease Urinary tract infection Co ureteral constriction Joint pain Back pain Muscle spasms Muscle pain Low energy Excessive sweating Muscle tremors Fluid retention in the legs and arms. Temporary blushing of the face and neck Decreased appetite Headache Vomiting Anxiety Low energy Severe stomach pain Feelings of dissatisfaction, sadness and discomfort. Night sweats Rare side effects of Hysingla ER include:
Decreased function of the adrenal glands Adrenal gland problems Hypogonadism in women Abnormal function and functioning of the testicles Dehydration Low blood potassium Depression Increased spinal fluid pressure Internal bell ringing High blood pressure Insufficient blood supply to the large intestine Intestinal paralysis Intestinal obstruction due to decreased intestinal motility Bile duct constriction Allergic dermatitis Eyebrows urticaria Muscle stiffness Hallucinations Convulsions Sleep apnea Fever Skin rash Anaphylaxis Abnormal muscle movements Pancreatitis Nightmares Stomach or intestinal irritation Inability to get an erection Neck pain Difficulty sleeping Loss of taste muscle coordination Heart pounding Difficulty swallowing Pins-pointing sensation in the skin Muscle or bone pain This is not a complete list of Hysingla possible side effects. If you notice other side effects of Hysingla ER not listed above, contact your doctor right away.

Before taking Hysingla ER, tell your doctor if you are allergic to this medicine; or other opioids (such as benz hydrocodone, codeine, hydromorphone) and any other allergies if applicable. Hysingla ER products may contain inactive ingredients, and they may cause allergic reactions or other problems.
Before using Hysingla ER, tell your doctor your medical history, especially of: Brain problems (such as head injury, tumors, epilepsy), breathing problems (such as asthma, sleep apnea, chronic obstructive pulmonary disease (COPD), gallbladder disease, kidney disease, liver disease, mental/mood disorders (such as confusion, depression, suicidal thoughts) , personal or family history of substance use disorders (such as drug/alcohol abuse or addiction), stomach/intestinal problems (such as bowel obstruction, constipation, diarrhea caused by infection) , paralytic ileus), pancreatitis, difficulty urinating, difficulty swallowing.
Hydrocodone may cause a condition that affects heart rhythm (QT prolongation). However, this condition can rarely cause severe (rarely fatal) fast/irregular heartbeat and other symptoms (such as dizziness, fainting) that require immediate medical attention.
Hysingla ER may make you dizzy or drowsy and alcohol and marijuana may make you more dizzy or drowsy. Do not drive, use machines, or do anything that requires alertness while using Hysingla ER until you can do so safely.
Before surgery, tell your doctor or dentist that you are using Hysingla ER.
Older adults may be more sensitive to the side effects of Hysingla ER, especially confusion, dizziness, drowsiness, slow/shallow breathing, QT prolongation.
For women during pregnancy, Hysingla ER should only be used when absolutely necessary, because it can harm the unborn baby. Discuss the risks and benefits of Hysingla ER with your doctor.
Hysingla ER passes into breast milk and may have unwanted effects on a newborn baby. If your baby is unusually sleepy, has trouble feeding, or has trouble breathing, tell the doctor right away. Women who are breastfeeding should consult their doctor before using Hysingla ER.

Drug interactions can change the way Hysingla ER works or increase your risk of serious side effects. Tell your doctor about all the medicines you use. Do not start, stop, or change the dose of any medicine while using Hysingla ER without your doctor's approval.
Some drugs that may interact with Hysingla ER include: Certain pain relievers (mixture of opioid agonists such as pentazocine, nalbuphine, butorphanol), naltrexone.
Other drugs may affect the removal of hydrocodone from your body, which may affect how hydrocodone works. Such drugs include macrolide antibiotics (such as erythromycin), mifepristone, azole antifungals (such as ketoconazole), HIV medicines (such as ritonavir), rifamycins (such as rifabutin, rifampin), certain drugs used to treat seizures (eg, carbamazepine, phenytoin).
The risk of serious Hysingla side effects (such as slow/shallow breathing, severe drowsiness/dizziness) may be increased if it is taken with other products that can also cause drowsiness. or breathing problems.
Tell your doctor if you are also taking other products such as other opioid pain relievers or cough suppressants (such as codeine, oxycodone), alcohol, marijuana, sleeping or anti-anxiety medications (such as alprazolam, lorazepam, zolpidem), a muscle relaxant (such as carisoprodol, cyclobenzaprine), or an antihistamine (such as cetirizine, diphenhydramine).
Hysingla may interfere with certain laboratory tests (including amylase/lipase levels), possibly causing false test results. Make sure laboratory staff and all your doctors know you are using this medicine.

If you or someone else has overdosed on Hysingla and has severe symptoms such as fainting or difficulty breathing, give them naloxone if available, then call 911 immediately. Other symptoms of Hysingla overdose may include: Slow breathing, slow heart rate, coma.
If you miss a dose of Hysingla, skip the missed dose. Use your next dose at the usual time, do not take a double dose.

Store Hysingla at room temperature, away from light and moisture, not in the bathroom, and keep it away from children and pets. Dispose of Hysingla medication appropriately when it has expired or is no longer needed.

Reference source: webmd.com