Lumoxiti: Uses, indications and cautions when using

Lumoxiti is used to treat a type of cancer called hair cell leukemia. This is a chemotherapy drug that slows or stops the growth of cancer cells.

Lumoxiti is indicated in the treatment of hairy cell leukemia.
Lumoxiti is contraindicated in the following cases:
Low blood calcium Hemolytic uremic syndrome, a condition that affects the kidneys and blood. Decreased kidney function Pregnancy

Carefully read the medication instructions provided by your doctor before you start using Lumoxiti and each time you are given a refill. If you have any questions about how to use Lumoxiti, ask your doctor. Lumoxiti is given by injection into a vein as directed by your doctor, usually lasting more than 30 minutes. Administration of the drug is usually done by a healthcare professional, usually on days 1, 3, and 5 of a 28-day treatment cycle. To reduce your risk of Lumoxiti side effects, drink plenty of fluids (such as water, milk, or juice) on days 1 to 8 of each treatment cycle. Depending on your weight, you should drink up to eight or up to twelve full glasses (8 ounces/240 milliliters each) of fluids on these days as directed by your doctor. The dose of Lumoxiti is based on your medical condition, weight, and response to treatment. Your doctor may prescribe other medicines (such as acetaminophen, an antihistamine) before and after each dose of Lumoxiti to lessen the reaction during your treatment. Carefully follow your doctor's instructions for all of your medications. Medical checks such as weight, blood pressure, kidney function, blood tests, salt/mineral levels should be done before you start using Lumixiti and while you are using it. Women of childbearing age should take a pregnancy test before starting Lumoxiti.

Side effects of Lumoxiti usually occur during injection. Tell your healthcare professional right away if you have symptoms during injection such as chills, fever, flushing, headache, nausea, vomiting, trouble breathing, fast heartbeat or pain muscle. Your doctor may temporarily stop treatment if a serious reaction occurs. During treatment with Lumoxiti, you may experience nausea, diarrhea, or constipation. If any of these Lumoxiti side effects persist or get worse, tell your doctor right away. People using Lumoxiti can have serious side effects. However, your doctor has given you this medicine because they have judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor can reduce the risk of unwanted effects. Tell your doctor right away if you have any serious side effects of Lumoxiti, including: Muscle cramps, numbness/tingling, fast/irregular heartbeat, eye problems ( such as blurred vision, dry eyes, eye discomfort/pain). Lumoxiti can lower your ability to fight infections, make you more likely to get serious infections, or make any infections you have worse. Tell your doctor right away if you have any signs of an infection such as a sore throat that doesn't go away, fever, chills, cough. A very serious allergic reaction to Lumixiti is very rare. However, if you notice any symptoms of a serious allergic reaction to Lumoxiti, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, Get medical help right away. Below are Lumoxiti side effects by likelihood.
Common side effects of Lumoxiti include:
Low blood albumin protein low blood phosphate low blood calcium low blood sodium low blood potassium Anemia Low neutrophil level Capillary leakage Kidney damage Decreased kidney function High levels of bilirubin in the blood High levels of Transaminase Alanine High levels of Aspartate Transaminases Fluid retention Constipation Fever Low energy Chills Visible fluid retention Headache Nausea Illness Diarrhea Uncommon side effects of Lumoxiti include:
Low blood magnesium levels Hemolytic uremic syndrome Decreased blood platelets Hemorrhage from the conjunctiva of the eye High blood pressure Pericardial fluid Low blood pressure Drainage into the lungs Kidney failure Ascites Blurred eyes Red eyes Dry eyes Fluid accumulation around the eyes Eye discharge Eye discharge Dizziness Puffy face due to water retention Temporary blushing of the face and neck Weight gain Cough Vomiting Stomach bloating Increased protein in the urine Heart palpitations This is not a name Full list of the possible side effects of Lumoxiti. If you notice other side effects of Lumoxiti that are not listed above, contact your doctor right away.

Before using Lumoxiti, tell your doctor if you are allergic to this medicine and any other allergies if any. Lumixiti products may contain inactive ingredients that may cause allergic reactions or other problems.
Before using Lumoxiti, tell your doctor your medical history, especially of: Kidney problems, other bleeding/blood problems.
Lumoxiti may make you more susceptible to infections or may worsen any existing infections. So you need to avoid contact with people who have infections that can spread to others (such as chickenpox, measles, flu).
Do not receive vaccinations / vaccinations during treatment with Lumoxiti, without the consent of your doctor. You also need to avoid contact with people who have recently received a live attenuated vaccine (such as the nasal flu vaccine).
Lumoxiti can make you dizzy and alcohol and marijuana can make you more dizzy. Therefore, do not drive, use machines, or do anything that requires alertness while using Lumoxiti, until you can do so safely.
Before surgery, tell your doctor or dentist that you are being treated with Lumoxiti.
Older adults may be more sensitive to the side effects of Lumoxiti, especially kidney damage.
Tell your doctor if you are pregnant or plan to become pregnant before using Lumixiti. You should not become pregnant while using Lumoxiti, because it can harm an unborn baby. Women of childbearing age should ask about reliable forms of birth control while using Lumixiti and for at least 30 days after stopping treatment. If you become pregnant, talk to your doctor right away about the risks and benefits of Lumoxiti.
It is not known whether Lumoxiti passes into breast milk, women who are breast-feeding should consult their doctor before using the drug.

Drug interactions can change the way Lumoxiti works or increase your risk of serious side effects. Tell your doctor about all the medicines you use (including prescription/nonprescription drugs and herbal products). Do not start, stop, or change the dose of any medicine while you are using Lumoxiti, without your doctor's approval.

If you or someone else has overdosed on Lumoxiti and has severe symptoms such as fainting or difficulty breathing, call 911 immediately.
For the best possible benefit, it is important to receive each dose of Lumoxiti on the schedule directed by your doctor. If you miss a dose, contact your doctor immediately to set up a new Lumixiti dosing schedule.
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Reference source: webmd.com