Promethazine side effects and indications

Promethazine is prepared in many different forms such as tablets, solution for injection, suppository rectal suppository, topical cream or oral syrup with the main active ingredient being Promethazine.
Active ingredient Promethazine is an Ethylamino derivative of Phenothiazine. However, the side-chain structure and the absence of a ring substitution are the features that distinguish Promethazine from the antipsychotic phenothiazines.
Promethazine has an anti-histamine effect through the mechanism of blocking H1 receptors by competing with Histamine at the positions of H1 receptors on the effector cells. However, Promethazine does not prevent histamine release. In addition, Promethazine also has a central nervous system depressant effect, manifested by strong sedative properties.

Prophylaxis and treatment of hypersensitivity allergic reactions such as angioedema, urticaria, pruritus, conjunctivitis, allergic rhinitis. Treatment of anaphylactic reactions after drug administration. Pain relief or sedation before surgical and obstetric procedures and surgeries. Sedation for children and adults. Temporary treatment of insomnia in adults. Prevention and treatment of motion sickness or seasickness. Anti-nausea, anti-vomiting. Combined with drugs containing the active ingredient Pethidine hydrochloride has a pre-anesthetic effect.

People with hypersensitivity to any of the ingredients in Promethazine. History of allergy to drugs containing the active ingredient Promethazine The person is in a comatose state. People who are taking high doses of central nervous system depressants. Children under 2 years old. People with a history of agranulocytosis. Patients with prostate disease have complications of urinary retention. People with closed angle glaucoma.

Common: blurred vision, somnolence, increased or decreased blood pressure after parenteral administration, skin rash, thick mucus. Uncommon: fatigue, dizziness, loss of coordination, tinnitus, double vision, insomnia, seizures or excitability, tremor, hysteria dissociation disorder, decreased heart rate, syncope after oral administration injection, thrombosis at the injection site. Rare: confusion, frequent nightmares, unusual agitation, restlessness, restlessness, extrapyramidal reactions such as torticollis, tongue protrusion, eye rotation disorder, atopic dermatitis, jaundice or hypersensitivity with light, cold urine. In case of experiencing undesirable effects after using drugs containing the active ingredient Promethazine, the drug should be stopped immediately. Immediately contact the treating doctor about the condition after taking the medicine or immediately go to the nearest medical examination and treatment facility for timely treatment.