The effect of the drug Neometin

Neometin is a drug to treat vaginitis caused by Trichomonas and Gardnerella vaginalis, Candida albicans fungus, and Trichomonas and yeast infections. At the same time, Neometin suppositories also have a good effect in the treatment of vaginitis caused by many factors in combination. The drug is used for prevention 5 days before and after the intervention of gynecological procedures.

Each Neometin suppository tablet includes the following main active ingredients:
Nystatin 22.73mg. Metronidazole 500mg strength. Neomycin Sulfate contains 108.3mg. Excipients 1 capsule. Dosage form: Non-film coated tablets, vaginal tablets.
Active ingredient Nystatin is a polyene fungicide and is sensitive to molds and yeasts - including Candida. The drug is used in the treatment of diseases such as fungal infections of soft tissues and mucous membranes such as thrush, pharyngitis, vaginitis,...
Nystatin is poorly absorbed from the gastrointestinal tract, the drug is not absorbed through the mucosa. and skin surface. The drug is mainly eliminated from the gastrointestinal tract in the form of unmetabolized feces.

Effects of ingredients in Neometin suppositories:
Nystatin: This is an antifungal antibiotic with inhibitory and fungicidal activity. The mechanism of action is to bind to sterols in the fungal cell wall, leading to changes in membrane permeability, causing leakage of substances in the cell to the outside. From there, the fungus will be destroyed. Metronidazole: A derivative of 5-Nitro-Imidazol. This component exerts a bactericidal effect by converting it to a cytotoxic mediator in the parasite. The drug then binds to the helical structure of the DNA, causing the DNA strands to break, killing the bacteria. Metronidazole is a component that has good effects on both intra- and extra-intestinal amoeba, both acute and chronic. With chronic amoebic dysentery in the intestine, the drug has a weaker effect due to the less penetration of the drug into the colon. The drug also works well with Trichomonas vaginalis, Giardia, gram-negative anaerobic bacteria including Bacteroid, Clostridium, Helicobacter but has no effect on aerobic bacteria. The nitro group in the active ingredient metronidazole is reduced by electron transport proteins or by ferredoxin. The reduced form of metronidazole has the ability to lose the helix structure of DNA, killing bacteria and protozoa. Neomycin Sulfate: This is a bactericidal effect by inhibiting protein synthesis in susceptible bacteria. The spectrum of action of Neomycin is mainly against Gram-negative bacteria. Neomycin is poorly absorbed from the gastrointestinal tract and due to its high toxicity to the kidneys and the auditory nerve, it is mainly used in addition to local treatment (usually in combination with bacitracin, polymyxin) or orally to kill bacteria. Intestinal aerobic in preparation for gastrointestinal surgery. Indications for use in the treatment of diseases caused by the following agents:
Vaginitis caused by common pyogenic bacteria. Vaginitis caused by simultaneous infection with Trichomonas and Gardnerella vaginalis. Vaginitis is caused by the fungus Candida albicans. Vaginitis caused by simultaneous infection with Trichomonas and yeast. Vaginitis is caused by many causes. Prevention 5 days before and after gynecological procedures.

Some unwanted effects may arise during the use of Neometin suppositories. Common side effects when taking the drug include:
Vaginal itching ; skin rash; Mild swelling; Dizzy; Shortness of breath; Stomach pain; Nausea, vomiting; Burning inside the vagina. The reaction of Neometin suppositories is different for each person. Therefore, you may experience side effects that are not mentioned in the article content. When you see any unusual symptoms arise, you should contact your doctor for instructions on how to correct. At the same time, in case the above symptoms persist or tend to get worse, you need to stop using the drug and go to a hospital with a specialist in Obstetrics and Gynecology for laboratory tests and diagnosis. reason.

4.1. How to use Neometin You need to carefully read the instructions for use printed on the package before use. When you still have questions about how to use, please talk to your doctor for specific instructions. The way the drug is used depends on the dosage form.
How to use the drug as follows:
Oral tablet: The drug can be used directly with filtered water. You should swallow the pill whole when taking it to ensure the therapeutic effect. In case you have oral thrush, your doctor may suggest that you swallow the tablet whole. Oral solution: You can use a medical measuring device to measure the prescribed amount of medicine. Then drink directly or dilute with water. Vaginal tablets: You should clean your hands and private area before proceeding to insert the medicine. To easily remove the tablet from the aluminum case, scissors can be used along the length. Dip the tablet in water for about 20 to 30 seconds, then proceed to insert the pill into the vagina. Limit movement for 10 to 15 minutes after the medication is placed. Vaginal suppositories need to be inserted deep inside the vagina by means of an assistive device. After each use, tools need to be washed and dried. Vaginal suppositories can be used during menstruation. Topical: You should clean your hands and the skin to be treated before coming into contact with the medicine. Apply a small amount of the medicine and gently massage the infected skin area. Your doctor may direct you to use the medicine differently. You should follow the instructions of the specialist to achieve the best treatment results. Before coming into contact with Neometin suppositories, you need to wash your hands and private areas to limit the situation of the tablet being infected. After taking the medicine, wash your hands with soap.
You should take the medicine at night before going to bed. This is the time of sedentary, active. This helps the medicine to penetrate deep into the vagina and be fully absorbed. Dosage of Neometin is indicated based on the degree of infection of each person. Therefore, you need to consult a specialist to determine the condition of the disease before using the drug treatment.
4.2. Neometin drug dosage Information on Neometin dosage in the article only responds to common diseases. If your condition is accompanied by special symptoms, you need to inform your doctor so that the dose can be adjusted.
Usual drug dosage is as follows:
Take 1 tablet / time / day Treatment time is about 10 consecutive days Can be increased to 2 tablets / day If during use, menstruation occurs, you should contact with your doctor for professional advice. Do not arbitrarily stop the drug during this time as this may cause the fungal infection to return.
Currently, there is no study on the dose for children, so parents should not arbitrarily give drugs to children without the consent of the treating doctor.
4.3. How to handle missed dose, drug overdose: When missed dose Neometin:
Skip the missed dose if the time interval is close to the time for the next dose, set the next dose as scheduled. Do not prescribe a double dose of the usual dose. Missing a dose can affect the effectiveness of treatment. When Neometin overdose:
Symptoms: There are no reports of symptoms in overdose. If you accidentally overdose on the medicine and have serious unwanted side effects, you need to immediately go to the medical center for timely treatment.

Neometin suppositories may decrease the effectiveness of some vaginal and vaginal suppositories. To prevent this, your doctor may recommend reducing the frequency or dose of each medication.
In addition, Neometin suppositories may also interact with the following drugs:
Anticoagulants: Lithium, Warfarin, Disulfiram, Phenytoin,... Antifungal drugs: Metronidazole, Nystatin,... You need to exchange Talk to your doctor for a complete list of medications that may interact with Neometin suppositories.

Pregnancy: Metronidazole has been reported to cause teratogenic conditions when used during the first 3 months of pregnancy. Therefore, do not use Neometin suppositories unless absolutely necessary. Nursing mothers: The drug is likely to be excreted in breast milk, so discontinue use while breastfeeding. People who drive and operate machines: The side effect of the drug is dizziness affecting the ability to drive and use machines, you need to be careful in this case. Do not have vaginal sex while using Neometin suppositories. If a hypersensitivity reaction occurs, immediately discontinue the drug and take appropriate measures. Neometin is a drug that works to treat inflammation of the vagina due to many causes. To ensure effective use and avoid unwanted side effects, you should carefully read the instructions or strictly follow the instructions of the treating doctor.