Tolperisone side effects

Tolperisone is a muscle relaxant indicated for: spasticity after stroke, spinal cord injury, acute muscle spasm, multiple sclerosis, encephalitis...

Tolperisone is a muscle relaxant that acts on the central nervous system. Tolperisone is usually indicated in the following cases:
Treatment of spasticity after stroke in adults; Treatment of spinal cord injury in the back; Treatment of acute muscle spasms; Multiple sclerosis ; Meningoencephalitis with or without dystonia. Tolperisone is prepared in the following forms and strengths:
Tablets with content of 50mg, 100mg, 150mg; Injection 100mg/1ml; Film coated tablets 50mg, 150mg.

The muscle relaxant Tolperisone is usually taken with or after a meal. If Tolperisone is being used concomitantly with other CNS-acting muscle relaxants, the user should consider reducing the dose of Tolperisone if necessary.
Suggested dose of Tolperisone:
Adults: Take a daily dose of 150-450mg, divided into 3 equal parts depending on the needs and responsiveness of each patient. For parenteral administration, Tolperisone hydrochloride should be administered intramuscularly at a dose of 100 mg twice daily, or by slow intravenous injection with a single dose of 100 mg/day; Children: Currently, Tolperisone injection has not been tested for safety in children, so this medicine should not be used in children. For film-coated tablets, children under 6 years of age can take a dose of 5mg/kg body weight/day (divided into 3 equal parts). For children 6-14 years old, the daily dose is 2-4mg/kg body weight (also divided into 3 equal parts); Patients with hepatic and renal impairment: Information on the use of the muscle relaxant Tolperisone in patients with hepatic and renal impairment is still limited, but an increase in the incidence of adverse events has been observed in this group of patients. this multiplier. Therefore, for patients with moderate hepatic and renal impairment, the dose should be determined for each patient in combination with close monitoring of disease status and liver and kidney function. Tolperisone is not recommended for patients with severe disease;

During treatment, Tolperisone muscle relaxant may cause some side effects as follows:
Myasthenia gravis (muscle weakness); Headache; Lower blood pressure; Nausea and vomiting; Stomachache. Most of these side effects will go away when the dose is reduced. Very rarely, hypersensitivity reactions such as pruritus, urticaria, angioedema, dyspnoea, anaphylaxis have been reported.

Do not use Tolperisone muscle relaxant for the following cases:
People with hypersensitivity to tolperisone hydrochloride, active substances with similar chemical structure to tolperisone or to any of the ingredients of the drug. Patients with severe myasthenia gravis. Due to the lack of appropriate study results, the use of Tolperisone injection in children is contraindicated. Relative contraindications:
Pregnant women in the first 3 months of pregnancy. The effect of the drug on breast milk is unknown, so Tolperisone should not be used during breastfeeding. Tolperisone is a muscle relaxant indicated for use in cases of: spasticity after stroke, spinal cord injury, acute muscle spasms, multiple sclerosis, encephalitis... To ensure effective treatment and To avoid unwanted side effects, patients need to use prescription drugs or consult a doctor or pharmacist for advice.
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