Uses of Acetaminophen Aspirin Codeine

Acetaminophen Aspirin Codeine is made in the form of capsules with different strengths according to the ratio Acetaminophen: Aspirin: Codeine is 150mg/180mg/15mg, 150mg/180mg/30mg, 150mg/180mg/60mg. Other excipients include starch, sodium lauryl sulfate, gelatin. The physicochemical characteristics of the ingredients are as follows:
Acetaminophen : Has a chemical name of 4' - hydroxyacetanilide, belongs to the group of pain relievers and antipyretics, not opiates, not salicylate. Acetaminophen exists as a white, odorless, crystalline powder with a slightly bitter taste; Aspirin: Also known as salicylic acid acetate, belongs to the group of non-steroidal anti-inflammatory drugs (NSAIDs). Aspirin exists in the form of a white powder, or crystallizes in the form of a needle and has no odor; Codeine: An alkaloid obtained naturally from the poppy plant or synthesized from morphine by methylation. Codeine phosphate exists as white fine crystals, needle-shaped or white crystalline powder. The drug is affected by light.

Acetaminophen Aspirin Codein phosphate capsules combine the central analgesic effect of codeine and the peripheral analgesic effect of acetaminophen, aspirin. The active ingredients of the drug are well absorbed orally. The plasma half-life of acetaminophen is about 1 to 4 hours, and codeine is about 2.5 to 3 hours. Although the half-life of Aspirin is only about 15 minutes, its biological half-life in the therapeutic plasma concentration range is 6-12 hours.
The active ingredient Codeine taken orally will tend to retain half of its analgesic activity. Impaired first-pass metabolism is responsible for the higher oral efficacy of codeine compared with other centrally addictive analgesics of the same class such as morphine. After absorption, Codeine is partially metabolized by the liver, the metabolites are excreted in the urine. Approximately 10% of a dose of Codeine is demethylated to Morphine. The active ingredient Acetaminophen after absorption is widely distributed to most tissues in the body and is metabolized mainly in the liver. The unchanged drug is rarely excreted in the urine, but most of its metabolites appear in the urine within 24 hours of oral administration.
Aspirin is rapidly absorbed and almost completely hydrolysed to salicylic acid after oral administration. Salicyclic acid is eliminated by the kidneys as an inactive metabolite. Clearance of salicylic acid at high doses is sensitive to urinary pH and is reduced in patients with renal dysfunction.

Acetaminophen Aspirin Codeine is indicated for the relief of mild to moderate pain. Contraindicated in patients with bleeding disorders, patients allergic to any ingredient including acetaminophen, aspirin and codeine.

Dosage of Acetaminophen Aspirin Codeine depends on the pain level and the patient's ability to respond. It should be noted that tolerability to Codeine may be increased with long-term use and the incidence of adverse events is closely related to dose. Accordingly, a dose of Codeine greater than 60mg in adults does not have a strong analgesic effect, but only prolongs the duration of analgesia, and the risk of side effects is also significantly increased.
Dosage of Acetaminophen Aspirin Codeine is usually limited by the amount of Codeine in each capsule. For adults, the dose of codeine should not exceed 60mg / time and not more than 0.5mg / kg in children when absolutely necessary.
For capsules containing 15mg or 30mg of codeine phosphate, the usual adult dose is 1-2 tablets every 4-6 hours.

Acetaminophen Aspirin Codeine can cause some side effects as follows:
Common: Dizziness, lightheadedness, sedation, difficulty breathing, vomiting and nausea; Uncommon: Excitement, allergic reactions, constipation, dyspnea, abdominal pain; High doses of codeine have most of the disadvantages of mosphin, including respiratory depression; The most common adverse reactions associated with aspirin use are gastrointestinal bleeding, peptic ulcer disease, nausea, vomiting, diarrhea....

The use of Acetaminophen Aspirin Codeine may mask the symptoms or clinical course in patients with acute abdominal pain. Use caution when using the drug in the elderly, debilitated, severely impaired liver or kidney function, hypothyroidism, Addison's disease and prostate enlargement or urethral stricture. The active ingredient Aspirin in the drug has the ability to cause gastrointestinal bleeding, so its use is contraindicated in patients with peptic ulcer disease or patients with abnormal blood clotting. Ability to drive, operate machinery: Codeine active ingredient in the drug can cause mental impairment, reduce concentration. Therefore, patients should be careful when driving or operating machinery during drug treatment. Pregnant women: Use in the treatment of pregnant women only when the benefits outweigh the risks. In late pregnancy, the use of narcotic analgesics can cross the placental barrier, leading to the risk of respiratory distress in the neonate. Women who are breastfeeding: Active ingredients Codeine, Aspirin in the drug cross the breast milk barrier, so it may cause side effects for nursing babies. Therefore, to ensure safety, patients should not be treated with drugs during breastfeeding.

Overdosage of Acetaminophen Aspirin Codeine can lead to the following symptoms:
Acetaminophen Overdose: Dose-dependent potentially fatal liver necrosis is the most dangerous side effect. Renal tubular necrosis, hypoglycemic coma, and thrombocytopenia may also occur. Overdose symptoms include nausea, vomiting, irritability... In this case, the patient should be taken to a medical facility as soon as possible; Aspirin overdose: Symptoms include ringing in the ears, headache, dizziness, blurred vision, nausea, shortness of breath, rapid breathing, sweating, and sometimes diarrhea. In children, vomiting, increased breathing rate and body temperature often appear; Codeine Overdose: Respiratory depression is the typical symptom of Codeine overdose (respiratory rate reduction, cyanosis), drowsiness, lethargy, coma, skeletal muscle tremors, cold skin and dizziness, pulse rate. slow heart rate and low blood pressure. Severe drug overdose will result in respiratory arrest, circulatory collapse, cardiac arrest, and death.

Acetaminophen Aspirin Codeine can interact when used with the following drugs:
Pain relievers, antipsychotics, anti-anxiety drugs, CNS depressants (including alcohol); Anticholinergic drugs interact with active ingredients Codeine can lead to paralytic ileus; Increases the effect of anticoagulants; Acetaminophen Aspirin Codeine is made in capsule form with a combination of three main active ingredients: Acetaminophen, Aspirin and Codeine. The drug is indicated for mild to moderate pain. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take the drug exactly as directed by a doctor or pharmacist.
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