Uses of Acetydona 200 mg

What is Acetydona 200? 1 Acetydona 200mg tablet with the main ingredient is 200mg Acetylcysteine ​​and other excipients just enough. Acetylcysteine ​​is used as a mucolytic and antidote to paracetamol overdose. The drug works to reduce the viscosity of sputum in the lungs by splitting the disulfide bridge in the mucoprotein, facilitating the expulsion of sputum by coughing, orthostatic drainage or mechanical methods.
Acetylcysteine ​​is also used to protect against hepatotoxicity caused by paracetamol overdose by maintaining and restoring liver glutathione levels (important to inactivate the intermediate metabolism of hepatotoxic paracetamol). . In paracetamol overdose, a large amount of this metabolite produced by the major pathway (glucuronide and sulfate conjugation) becomes saturated. Acetylcysteine ​​is converted to cysteine, which stimulates the liver to synthesize glutathione. Acetylcysteine ​​may therefore be hepatoprotective if treatment is started within 12 hours of a paracetamol overdose. The earlier treatment is started, the more effective it is.
Indications: Use Acetydona 200mg drug in the following cases:
Acetydona 200 medicine to help dissolve sputum, support treatment in respiratory diseases, emphysema, bronchial multiple secretions,... Article treatment of diseases of the ear, nose and throat: Rhinitis, sinusitis, otitis media, pharyngitis, ... Used as an antidote in case of paracetamol overdose. Contraindications: Do not use Acetydona 200mg in the following cases:
People with a history of asthma; Children under 24 months old; Hypersensitivity to Acetylcysteine ​​or to any of its ingredients.

How to use: Use Acetydona 200mg by direct oral.
Dosage:
Use Acetydona 200 drug to eliminate mucus: For adults: Take 200mg/time x 3 times/day. Used as an antidote for paracetamol overdose: The first dose is 140mg/kg, the next dose is given once every 4 hours with a dose of 70mg/kg body weight and a total of 17 additional doses; Acetylcysteine ​​is highly effective when used within 8 hours of a paracetamol overdose. After that time, the protective effect of the drug gradually decreases. Note, if treatment is started more than 15 hours later, the drug is not effective. Acetydona 200mg overdose: When using an overdose of Acetylcysteine, the patient has symptoms similar to those of anaphylaxis but much more severe, especially a decrease in blood pressure. Other symptoms include: Hemolysis, respiratory failure, disseminated intravascular coagulation, and renal failure. Death has also occurred in a patient with an overdose of Acetylcysteine ​​while being treated for paracetamol toxicity. Treatment of Acetydona overdose is symptomatic treatment.

Some side effects patients may encounter when using Acetydona 200mg are:
Common: Nausea, vomiting; Uncommon: Headache, somnolence, tinnitus, runny nose, stomatitis, urticaria, skin rash; Rare: Fever, chills, bronchospasm with systemic anaphylactoid reactions. Note: Patients should inform the doctor about the unwanted effects encountered during the use of Acetydona 200mg for advice on the most effective measures.

Some things patients should note before and while using Acetydona 200 are:
Care should be taken when using the drug in patients with peptic ulcers; Patients with a history of allergies, asthma, if there is bronchospasm, should stop using the drug; Using Acetydona 200mg for pregnant and lactating women: Pregnancy: Treatment of paracetamol overdose with Acetydona in pregnant women is safe and highly effective, and has the ability to prevent toxicity for pregnant women. liver in both mother and fetus; Lactation: Acetydona 200mg is safe to use for breast-feeding women.

Drug interactions can affect the effectiveness of some drugs or increase dangerous side effects. Some drug interactions Acetydona 200 that patients and family members should pay attention to are:
Should take tetracycline away from the time of using Acetylcysteine ​​at least 2 hours; Acetylcysteine ​​should not be used concurrently with cough suppressants, as it may cause severe mucus congestion due to decreased cough reflex. Should consult with professional doctors before combined use to ensure safety and effectiveness; Acetylcysteine ​​should not be used concurrently with other drugs that reduce bronchial secretion; Acetylcysteine ​​may enhance the vasodilator and platelet aggregation inhibitory effects of nitroglycerin; Acetylcysteine ​​is a kind of reducing agent. Therefore, patients should pay attention not to combine drugs with oxidizing substances. During the treatment with Acetydona 200mg, patients should pay attention to listen to the doctor's instructions, and strictly follow them to achieve the desired effect, limiting serious side effects that may occur. out.
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