Uses of Aclop

Aclop drug has the main active ingredient Clopidogrel and other excipients. Aclop belongs to the group of cardiovascular drugs, which are effective in the primary prevention of disorders caused by thromboembolism.

Aclop drug belongs to the group of cardiovascular drugs, with the main active ingredient being Clopidogrel in the form of Clopidogrel bisulfate with a concentration of 75mg and other excipients. The drug is prepared in the form of film-coated tablets, suitable for direct oral administration. The packaging of Aclop is a box of 3 blisters, each blister contains 10 tablets. The drug Aclop is effective in the primary prevention of thromboembolic disorders. At the same time, the drug is also effective in secondary prevention for people with atherosclerosis who have recently had a stroke, a recent myocardial infarction, or known peripheral artery disease.

Aclop is effective in the treatment of the following pathologies:
Primary prevention of disorders caused by thromboembolism such as myocardial infarction, stroke or peripheral arterial diseases. Control and secondary prevention for atherosclerotic patients with recent stroke, recent myocardial infarction, or established peripheral arterial disease.

Clopidogrel is not affected by food, so it can be taken with or without food.
People with a history of atherosclerosis: the therapeutic dose is 1 tablet of Aclop 75mg per day. The prophylactic dose to prevent thromboembolic disorders such as myocardial infarction, peripheral artery disease and stroke is: 1 tablet of Aclop 75mg daily. A day. Note: No dose adjustment is required in the elderly or in patients with renal impairment. In case of overdose Clopidogrel can lead to prolongation of bleeding time and subsequent complications of bleeding. The signs and symptoms of acute toxicity are vomiting, fatigue, dyspnea, and gastrointestinal bleeding.

Clopidogrel is generally well tolerated. However, in the process of using the drug, there are also some unwanted effects, including:
Common unwanted effects: Gastrointestinal disorders (diarrhea, abdominal pain, indigestion and nausea) ) and skin allergies (erythema, pruritus). Common undesirable effects: Chest pain, nosebleeds. Rare adverse effects: Gastrointestinal bleeding, gastric ulcer, severe neutropenia or agranulocytosis, thrombocytopenia, thrombocytopenia purpura, aplastic anemia, kidney disease such as nephritic syndrome, loss of taste, acute arthritis. Other undesirable effects: decreased platelet count, intracranial hemorrhage, eye bleeding.

Some undesirable drug interactions that may occur when taking the drug include:
Aspirin: There may be a pharmacodynamic interaction between the active ingredient Clopidogrel and Aspirin leading to an increased risk of bleeding. Therefore, caution should be exercised when combining these two drugs. However, the active ingredient clopidogrel and aspirin can be combined for a period of up to 1 year. Heparin: A pharmacodynamic interaction between Clopidogrel and Heparin may lead to an increased risk of bleeding. Therefore, the simultaneous use should be noted. Warfarin: May increase the risk of bleeding, so when using the active ingredients Clopidogrel and Warfarin should be careful. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): In a study in healthy volunteers receiving naproxen, the concomitant use of naproxen and the active ingredient clopidogrel was associated with an increase in potential gastrointestinal bleeding. Therefore, caution should be exercised when Aclop is co-administered with non-steroidal anti-inflammatory drugs. Drugs Metabolized by the Cytochrome P450 System: At high concentrations in vitro, the active ingredient Clopidogrel inhibits Cytochrome P450 (2C9). The drug affects the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin and many other non-steroidal anti-inflammatory agents. However, there are no data on the severity of these types of interactions. Care should be taken when combining Aclop with the above drugs. Other Combination Treatments: Concomitant use with inhibitors of CYP2C19 enzyme activity may reduce concentrations of the active metabolite Clopidogrel. Therefore, caution should be exercised when co-administered with CYP2C19 inhibitors.

6.1. Contraindications of the drug Aclop Contraindicated to use the drug Aclop in people who are sensitive or hypersensitive to any of the ingredients of the drug. People with bleeding disorders such as peptic ulcers or intracranial hemorrhage.
6.2. Cautions and precautions of the drug Aclop Use caution when used in people with bleeding caused by trauma, surgery or other diseases. In case of people preparing for surgery, must stop using preparations containing the active ingredient Clopidogrel 5 days before surgery. Clopidogrel should be used with caution in patients with bleeding-prone lesions (such as ulcers). You need to be careful when using drugs that can cause similar damage to people who are taking Aclop. Caution should be exercised in subjects with hepatic impairment who have altered metabolism (poor metabolism due to CYP2C19) 6.3. Use of drugs in special groups For pregnant women: Currently, there are no adequate studies on the use of Aclop in pregnant women. Therefore, you should only take the drug during pregnancy when it is absolutely necessary after being weighed by the treating doctor between the benefits for the mother and the possible risks for the baby. For lactating women: There are currently no studies on the excretion of the active ingredient Clopidogrel in breast milk. Since many drugs can be excreted by this route, caution should be exercised when using preparations containing the active ingredient Clopidogrel, in particular Aclop, with nursing women. For people who often drive or operate machinery: Clopidogrel has no influence on the ability to drive and use machines. Therefore, you can use the drug while driving or doing work that involves operating machinery. Aclop medicine has the active ingredient Clopidogrel and other excipients as the main active ingredient. Aclop belongs to the group of cardiovascular drugs, which are effective in the primary prevention of disorders caused by thromboembolism. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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