Uses of Adelesing

Adelesing medicine is prepared in powder form, mixed with oral suspension, indicated for use in cases of otitis media, sinusitis, pharyngitis, pneumonia, bronchitis, urinary tract infections, skin infections. To ensure the effectiveness when using Adelesing, users need to follow the instructions of their doctors, and refer to more information about the uses of Adelesing in the following article.

1.1. What is Adelesing? Adelesing drug belongs to the group of anti-parasitic, anti-infective, anti-viral, anti-fungal drugs containing Cefaclor (in the form of Cefaclor monohydrate) 125mg. Excipients: Anhydrous Lactose, Microcrystalline Cellulose and Carboxymethylcellulose Sodium, Sodium Benzoate, Aspartame, No. 40 Red, Strawberry Flavor and Ethyl Vanillin.
The drug is prepared in the form of: Powder mixed with oral solution
1.2. What are the uses of Adelesing? Adelesing is used in the treatment of respiratory tract infections caused by susceptible bacteria:
Acute otitis media, acute sinusitis, pharyngitis and recurrent tonsillitis. Pneumonia and chronic bronchitis during exacerbation. Uncomplicated lower urinary tract infection (cystitis). Skin and soft tissue infections by susceptible Staphylococcus Aureus and Streptococcus Pyogenes.

2.1. How to take Adelesing Take Adelesing orally and take it on an empty stomach.
2.2. Dosage of Adelesing For adults:
Pharyngitis, bronchitis, tonsillitis, skin and soft tissue infections, lower urinary tract infections: Take an amount of about 250 to 500mg, take about 2 times a day; or 250mg and 3 times a day. For more severe infections: 500mg and 3 times a day. The dose limit usually prescribed for adults: Maximum of 4g per day. In case of severe renal impairment, the dose for adults should be adjusted as follows: If the creatinine clearance is 10 to 50 ml/min, use 50% of the usual dose; If creatinine clearance is less than 10 ml/min, use 25% of the usual dose. Patients requiring hemodialysis: During hemodialysis, the plasma half-life of cefaclor is reduced by 25-30%. Therefore, for patients on regular hemodialysis, a starting dose of 250 mg - 1 g should be used before hemodialysis and a maintenance dose of 250 - 500 mg every 6 to 8 hours and during interval between dialysis sessions. For children:
Use an amount from 20 to 40 mg/kg body weight/24 hours and divided into 2-3 oral doses.
For children with otitis media:
Give 40 mg/kg body weight/24 hours, divided into 2 to 3 times, but the total daily dose should not exceed 1g. The maximum daily dose for children should not exceed 1.5g.
For the elderly:
Dosage is the same as for adults.
Handling missed dose:
In case you forget a dose while taking the medicine, take it as soon as possible (usually it can be taken 1 hour - 2 hours after the time ordered by the doctor ). However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Note, do not use double the prescribed dose.
Overdose management:
Overdose management should consider the potential for multiple drug overdoses, drug interactions, and unusual pharmacokinetics in the patient. There is no need for gastric lavage unless cefaclor has been taken for 5 times the normal dose. Protect the respiratory tract for the patient, support ventilation and infusion. Reduce absorption of the drug by giving activated charcoal several times. In many cases this is more effective than inducing vomiting or gastric lavage. Can gastric lavage and add activated charcoal or just use activated charcoal. Diuresis, peritoneal dialysis, or hemodialysis have not been established to be beneficial in the treatment of overdose.

For patients with a history of hypersensitivity to Cephalosporins, especially to cefaclor, or to penicillins, or to other drugs. You need to be careful with patients allergic to penicillin, because there is cross-sensitivity. However, the frequency of cross-sensitization to penicillin is low. Long-term use of cefaclor can cause pseudomembranous colitis. Caution should be exercised in patients with a history of the gastrointestinal tract and especially colitis. Cefaclor should be used with caution in patients with severely impaired renal function. Because the half-life of cefaclor in anuria patients is 2.3-2.8 hours (compared to 0.6-0.9 hours in normal subjects), no dose adjustment is usually required in patients with renal impairment. moderate but dose reduction in patients with severe renal impairment. Because clinical experience with cefaclor is still limited, clinical monitoring is required. For pregnant women and lactating women:
Pregnant women: There are no adequate studies in pregnant women. Therefore, Cefaclor is indicated for use in pregnancy only when clearly needed. Lactation: Cefaclor concentrations in breast milk are very low. The effect of the drug on the nursing infant is unknown, but attention should be paid to diarrhea, thrush and rash.

When using the drug causes some effects on a few organs inside and outside the body:
Common: Eosinophilia, diarrhea, skin rash in the form of measles
Uncommon:
Whole body: When the direct Coombs test is positive. Blood: Lymphocyte increase, leukopenia and neutropenia. Gastrointestinal: Nausea and vomiting. Skin: Itching and hives. Urogenital: Genital itching, vaginitis and candidiasis. Rare:
Systemic: Anaphylactic reaction, fever, serum sickness-like symptoms, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome) and generalized pustular skin rash. Serum sickness-like reactions are more common in children than in adults: erythema multiforme, joint inflammation or pain, fever or not, may be accompanied by lymphadenopathy and proteinuria. Blood: Thrombocytopenia and hemolytic anemia. Gastrointestinal: Pseudomembranous colitis. Liver: Increased liver enzymes, hepatitis and cholestatic jaundice. Renal: Reversible interstitial nephritis, mild elevation of blood urea or serum creatinine or urinalysis will be abnormal. Central nervous system: Seizures (for high doses and impaired renal function), increased agitation, headache, restlessness, insomnia, confusion, hypertonia, dizziness, hallucinations and somnolence chicken. Other: Joint pain.

Concomitant use of cefaclor and warfarin rarely results in an increase in prothrombin time, clinically indicative of bleeding or non-bleeding. Patients with vitamin K deficiency (dietary, malabsorption syndrome) and patients with renal failure are the subjects at high risk of interactions.
For these patients you should regularly monitor the prothrombin time and adjust the dose if necessary.
Probenecid will increase the serum concentration of cefaclor. Concomitant administration of cefaclor with aminoglycoside antibiotics or furosemide diuretics may increase nephrotoxicity.
Above are the outstanding uses of Adelesing, before using, patients need to carefully read the instructions and use the drug as indicated to get the best treatment results.