Uses of Aleclo

What is Aleclo drug? Aleclo is an injectable solution of Diclofenac, a non-steroidal anti-inflammatory drug, also known as an NSAID, commonly used to reduce swelling (inflammation) and pain. Diclofenac is a potent inhibitor of the activity of cyclooxygenase (including at least Cox-1 and Cox-2) - an enzyme that catalyzes the conversion of arachidonic acid to prostaglandins, prostacyclin, thromboxane, mediators of the inflammatory response. The Cox-1 inhibitory effect of the drug causes platelet aggregation and inhibits the secretion of gastric mucosal protectant. The anti-inflammatory, antipyretic, and analgesic effects are mainly due to the inhibitory effect of Cox-2.
Thanks to the above mechanism, Aleclo is indicated for use in the treatment of the following conditions:
Short-term treatment of symptoms in acute exacerbation of periarthritis (tendonitis, bursitis), arthritis caused by gout, severe radiculopathy, osteoarthritis. Treatment of pain after orthopedic surgery, gynecological surgery, trauma, dentistry. Biliary colic, renal colic, severe migraine.

2.1. How to take Aleclo Aleclo will be provided by the medical staff in the hospital and monitored throughout the time you need to use the medicine. Drink extra fluids to urinate more before receiving this medicine. This can help prevent kidney problems. Aleclo is injected through a needle and infused into one of your veins (intravenous infusion) or intramuscularly deep into the upper 1⁄4 of your buttocks. For intravenous infusion, dilute each ampoule into 100-500ml of 0.9% NaCl or 5% glucose solution with 1ml of NaHCO3. 2.2. Dosage The usual intramuscular dose used is 1 ampoule of Aleclo 75mg/3ml, once a day. In severe cases, up to 2 intramuscular injections can be used per day (2 buttock injections).
If the injection is very painful, stop the drug immediately. The duration of treatment with this injection is from 2 to 3 days (if further treatment is needed, it can be changed to oral tablets or rectal tablets).
With intravenous line:
Administer 75 mg dose continuously for 30 minutes to 2 hours, and can be repeated after several hours but not more than 150 mg in 24 hours Or infusion dose of 25 to 50 mg immediately after surgery for 15 minutes to 1 hour, followed by a continuous infusion of 5 mg every hour up to a maximum of 150 mg/24 hours.

3.1 Special Warning Non-steroidal anti-inflammatory drugs in general and Aleclo in particular may increase the risk of heart attack or stroke. This effect can occur at any time while taking the drug. People who are older, have heart disease, or have risk factors for heart disease (such as smoking, family history of heart disease, high blood pressure, diabetes) are at higher risk. Do not take this medicine right before or after coronary artery bypass graft (CABG) surgery. Also, this medicine can rarely cause serious bleeding from the stomach or intestines without warning symptoms at any time while using it. 3.2 Contraindications Do not use Aleclo for the following cases:
Patients who are allergic to NSAIDs (Aspirin, Ibuprofen, ...), or any of the ingredients of the drug People with peptic ulcer disease Coagulation defects bleeding, bleeding Surgery with risk of massive blood loss Severe kidney failure Severe liver failure Heart failure 3.3. Drug Interactions Some medications that you are taking may interact with this drug. So give your doctor a list of all your medicines including prescription and over-the-counter medicines, vitamins, herbs, and supplements. Especially the following drugs:
Aliskiren ACE inhibitors (such as Captopril, Lisinopril), Angiotensin II receptor blockers Corticosteroids Cidofovir Lithium Methotrexate Diuretics Anticoagulants

In addition to the necessary effects, Aleclo injection can cause some common side effects such as pain at the injection site, dizziness. Less common side effects such as:
Abdominal pain or stomach pain Black or bloody stools Diarrhea Ợ sour Indigestion Indigestion Loss of appetite Nausea, vomiting Bloody urine Vomiting blood Back pain Facial swelling, Hands and feet may also experience side effects with unknown frequency such as fever or chills, difficulty speaking, chest pain, skin sores, red skin lesions, double vision, etc.
Talk to your doctor about the risks and benefits of treatment with Aleclo injection . To avoid the risk of side effects, you will be switched to another route of administration or to a different active ingredient as soon as possible.