Uses of Analgin

Analgin is an analgesic and antipyretic, in which the analgesic effect is considered the leading. The drug is indicated in the following diseases: cold, flu, high fever, joint pain, headache.... On the market today there is a lot of information about the drug product Analgin 500mg, but it is still incomplete. To better understand what Analgin 500mg is, what are the uses of Analgin, let's read more articles below.

Analgin international name is Metamizole sodium.antifebrile or Metamizole Sodium, belongs to the group of antipyretic, analgesic, anti-inflammatory drugs. The drug is prepared in the form of tablets with a strength of 500 mg. Analgin 500mg is indicated for use in anti-inflammatory, analgesic in the following cases:
Arthralgia, rheumatism, chorea, pain: headache, dental, menstrual, neuralgia, myalgia, myalgia, pain abdominal pain (kidney, liver, intestine), pulmonary infarction, myocardial infarction, aortic aneurysm, main vessel thrombosis, toothache, dysmenorrhea, spasmodic pain (gastrointestinal tract, biliary tract, urinary tract). ), pain due to neuritis, pain after surgery, pain due to cancer. Inflammatory processes (pleurisy, pneumonia, lumbago, myocarditis), trauma, burns, decompression sickness, shingles, tumors, orchitis, pancreatitis, peritonitis , perforation of the esophagus , pleurisy , complications after blood transfusion, priapism The drug is also used in febrile syndrome in acute infectious diseases, purulent and urinary tract (prostatitis), insect bites (mosquitoes), bees, butterflies, etc.).

2.1 Pharmacodynamics Analgin has anti-inflammatory, analgesic, anti-infective effects. Inhibits cyclooxygenase activity, reduces endoperoxide formation, bradykinin, some prostaglandins, free radicals, inhibits lipid peroxide oxidation. Blocks the transmission of extrasensory impulses and pain perception through Gaulle's fascists and Burdach's columns, increases the threshold of excitation of pain-sensitive hippocampal centers, increases thermogenesis. The action evolves in 20-40 mines and maxes out in 2 hours.
2.2 Pharmacokinetics When taken orally, the preparation is rapidly and fully absorbed. They are hydrolyzed in the intestinal wall with the formation of the active metabolite - unchanged Metamizol is not present in the blood. The active metabolite - 4-methyl-amino-antipyrine is in turn metabolized to 4-formyl-amino-antipyrin and other metabolites. The degree of binding of the active metabolite to proteins is 50-60%. Metabolites are eliminated in the urine and in breast milk.
2.3 Contraindications of Analgin 500mg As recommended, Analgin 500mg is contraindicated in the following cases:
Patients who are allergic to any ingredient or excipients of Analgin 500mg Hypersensitivity to including pyrazolone derivatives Hematopoietic impairment (agranulocytosis, cytostatic or infectious neutropenia) Severe hepatic or renal impairment Prostaglandin-induced bronchial asthma Patients with hypotension Hemolytic anemia transmission related to glucose 6-phosphate dehydrogenase deficiency Pregnant and lactating women (if the drug is necessary, the duration of treatment should be withdrawn). Note
Use drugs for children under 3 years of age need to be very cautious. Need to control peripheral blood image when taking long-term drugs. When taking Analgin, the red color of the urine may be due to the elimination of metabolites. 2.4. Analgin 500mg side effects Dizziness, headache, drowsiness Nausea, vomiting, dry mouth, difficulty swallowing, abdominal pain, diarrhea Skin rash, itching Kidney damage Low blood pressure Pink urine Agranulocytosis , thrombocytopenia, hemorrhage, interstitial nephritis, Allergic reactions (including Stevens-Johnson and Layell syndrome, bronchospasm, anaphylaxis). If you are taking this medicine for long-term care, your doctor may check your kidney function, liver function, and the levels of certain components in your blood regularly. Serious complications such as stomach bleeding and kidney problems can be caused with long-term use.
2.5. Notes when using Analgin 500mg A few important notes when using Analgin 500mg that patients should note:
The use of the preparation is necessary to perform under the control of a doctor. Should not be used regularly for a long time due to toxicity to the marrow. Do not use the drug to relieve acute abdominal pain (before explaining the reason). When administered to patients with acute cardiovascular disease, careful hemodynamic control is required. Use with caution in patients with ABP BP below 100 mm Hg, with a history of kidney disease (pyelonephritis, glomerulonephritis) and long-term alcohol abuse. It can be dangerous to use analgin 500mg during pregnancy. Although human studies are few, animal studies have shown adverse effects on developing infants. Before prescribing it for you, your doctor can weigh the benefits against any possible risks. If you have a history of heart disease or stroke, tell your doctor. When taking Analgin 500mg, stop drinking alcohol as it can increase the risk of stomach problems. If you are taking this medicine for long-term treatment, your doctor may check your kidney function, liver function, and the levels of certain components in your blood regularly.

Drugs for oral administration directly
Take Analgin 500mg tablets whole, do not crush or mix with any other mixture. Should be taken after meals to avoid stomach upset. Dosage
Recommended dosage: 250 to 500 mg x 2 to 3 times a day Maximum single dose is 1g, maximum daily dose is 3g. For children, a single dose of 5-10 mg/kg is recommended. The usual dose for children 2-3 years old is 50-100 mg, 4-5 years old is 100-200 mg, 6-7 years old is 200 mg, 8-14 years old is 250-300 mg 2-3 times a day. Overdose
Signs: hypothermia, manifestations of hypotension, palpitations, dyspnea, tinnitus, nausea, vomiting, fatigue, drowsiness, delirium, impaired consciousness, convulsive syndrome; May develop acute agranulocytosis, hemorrhagic syndrome, and acute liver and kidney failure. Treatment: induce vomiting, gastric lavage, saline laxatives, activated charcoal and artificial diuresis, blood alkalinization, symptomatic treatment towards maintaining vital functions. Above is important information about the drug Analgin. The fact that you actively know how to use and use will bring positive effects in the treatment of diseases.