Uses of Apuric 100

1.1. General introduction of the drug Apuric 100 Apuric 100 has the main active ingredient, Allopurinol, with a strength of 100mg and other excipients in sufficient quantities. The drug has analgesic, antipyretic, non-steroid anti-inflammatory effects. At the same time, this drug is also used in the treatment of gout and joint diseases.
Apuric 100 is made in the form of tablets, suitable for direct oral administration. Packing is a box of 2 blisters, each blister contains 10 tablets.
1.2. Pharmacodynamics of the active ingredient Allopurinol: Allopurinol is used to reduce uric acid in the blood. Uric acid is a breakdown product of purines in food. Uric acid forms crystals that remain in body tissues causing gout. Increased uric acid levels in the blood can also cause kidney diseases and kidney stones. Allopurinol is used to prevent kidney stones caused by uric acid and to prevent attacks of gouty arthritis.
1.3. Pharmacokinetics of the active ingredient Allopurinol Absorption: The active substance Allopurinol is almost completely absorbed from the gastrointestinal tract. The active ingredient Allopurinol reaches its maximum concentration 4 hours after oral administration. Distribution: Active ingredient Allopurinol is less bound to plasma proteins, volume of distribution is 0.6 l/kg. Metabolism: The active ingredient Allopurinol is converted to oxypurinol, which is still active. Elimination ability: Allopurinol is excreted in the urine mainly in the form of metabolites, the mean half-life is about 1 hour (oxypurinol is 18-20 hours). 1.4. The effect of active ingredient Allopurinol reduces uric acid levels in the blood mainly by competitively inhibiting the synthesis of uric acid in the urine, thus causing less kidney stones and kidney pain. Mechanism of action of the active ingredient Allopurinol: an inhibitor of the enzyme xanthin oxidase, which is the enzyme responsible for converting the precursors hypoxanthine and xanthin to uric acid. This reduces uric acid levels in the blood.

Apuric 100 is effective in the treatment of the following diseases:
Treatment of gout or acute exacerbations. Prevention of uric acid nephropathy when treating cancer. Control of Ca regressive stones in patients with increased urinary uric acid excretion.

Apuric 100 is made in the form of tablets, suitable for direct oral administration. Dosage reference is as follows:
Dosage for mild gout: 200 - 300 mg/day, severe: 400 - 600 mg/day, Acute exacerbation: minimum effective dose: 100 - 600 mg/day. 200 mg/day, the maximum dose is 800 mg/day. Prophylaxis of uric acid nephropathy when treating cancer, the dose is 600-800 mg/day, for 2 or 3 days. Control of stones Ca regression for patients with increased uric acid urinary excretion dose is 200-300 mg/day, divided into several times a day.

Side effects of Apuric 100 include nausea, diarrhea, skin rash with low-grade fever, increased alkaline phosphatase, increased liver enzymes, acute gout flares with blisters.
It should be noted: The above is not a complete list of all undesirable effects of Apuric 100. In the process of using this drug, there may be other side effects that have not been shown or have not been studied. If you see any other side effects of Apuric 100 not specified in the instructions for use, you need to actively inform your doctor.

When using two or more drugs at the same time, it is easy to cause drug interactions leading to antagonism or drug synergies.
Avoid using Apuric 100 for people who have had a severe reaction to the drug in the past. Allopurinol can trigger a flare-up of gouty arthritis while blood uric acid levels are initially being corrected. Therefore, it is necessary to use colcicine concurrently to prevent these flare-ups. Do not start Apuric 100 while the inflammation is active, as it may worsen and prolong an attack of gouty arthritis. People who are taking Purinethol or Imuran concurrently need to reduce the dose of these drugs. The risk of skin rash is increased in people who are taking Ampicillin and Amoxicillin. Allopurinol can cause severe allergic hepatotoxicity and even death. Loss of appetite and itching are signs of liver toxicity. The risk of this reaction is increased in people with kidney failure. Therefore, people with kidney disease need to reduce the dose. Apuric 100 is used in children to treat cancer or some other rare disease of purine metabolism. Drug interactions Apuric 100 with foods and drinks: When using Apuric 100 with foods or alcohol, beer, tobacco can cause interactions because in those foods or drinks contain these substances. other active ingredients, which can cause antagonism or synergistic effects with the drug. You should actively read the instructions for use of Apuric 100 medicine carefully or consult your doctor or pharmacist about using Apuric 100 with food, alcohol and tobacco.

Note before using Apuric 100:
You should take this medicine with plenty of water. Stop taking the medicine if you notice skin rashes, painful urination, bloody urine, eye irritation or swelling of the lips or mouth. General note in pregnancy: Apuric 100 used during pregnancy can cause adverse effects such as miscarriage, teratogenicity, fetal malformations... to any stage of fetal development. period, especially during the first trimester. Therefore, it is best not to use this drug for pregnant women. In cases where it is absolutely necessary to use, it is necessary to consult carefully with the treating doctor or pharmacist before making a decision. General precautions during lactation: Apuric 100 can be passed to a baby through breast milk. It is best not to or limit the use of this drug while breastfeeding. Currently, many drugs have not yet fully determined the effects of drugs in this period, so mothers need to carefully read the instructions for use and consult the treating doctor before deciding to use the drug. this. Apuric 100 has the main active ingredient, Allopurinol, 100mg and other excipients in sufficient quantities. The drug has analgesic, antipyretic, non-steroid anti-inflammatory effects. At the same time, this drug is also used in the treatment of gout and joint diseases. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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