Uses of Atorpa E

Atorpa e 40/10 is a prescription drug for cases of cardiovascular disease, hypercholesterolemia or hypertension. When using Atorpa e, patients need to carefully read the instructions on the drug packaging or follow the course that the doctor has oriented before.

Atorpa e 40/10 belongs to the group of cardiovascular drugs, helping to treat and prevent cardiovascular diseases, hypertension or hypercholesterolemia. Atorpa e is prepared in the form of film-coated tablets and packed in boxes of 3 blisters x 10 tablets. In each Atorpa e tablet contains the following main ingredients:
Atorvastatin (as Atorvastatin calcium trihydrate) 40mg. Ezetimibe 10mg. Excipients are sufficient in one tablet.

2.1 Indications to use Atorpa e Atorpa e is mainly indicated for the following cases:
Prevention of cardiovascular disease: Atorpa e is indicated for use in order to reduce the risk of events. cardiovascular disease in people with coronary artery disease, a history of acute coronary syndrome, or who have not been previously treated with statins. Treatment of hypercholesterolemia: Indicated Atorpa e as adjunctive therapy for people with primary hypercholesterolemia (heterozygous with/without familial), mixed dyslipidemia when using combination products Suitable for: Patients already treated with Ezetimibe and Statins. The patient did not respond to treatment with statins alone. Treatment of homozygous familial hypercholesterolemia: Atorpa e is used as adjunct to the diet of patients in this group. In addition, patients may also use some other complementary treatments, such as LDL cholesterol removal. 2.2. Contraindications to the use of Atorpa e Do not use Atorpa e in the following cases:
Patients with a history of allergy or hypersensitivity to Ezetimibe, Atorvastatin or any other drug contained in the drug. Patients with active liver disease or long-term unexplained elevations in serum transaminases above the upper limit of normal 3 times. Atorpa e is contraindicated for women who are pregnant, planning to become pregnant or nursing mothers. Atorpa e is contraindicated in patients with unstable heart failure.

3.1 Dosage of Atorpa e The dosage of Atorpa e will be determined specifically based on treatment goals as well as certain patients:
Dose to treat hypercholesterolemia and coronary artery disease:
Take 10 / 10mg - 80 / 10mg / day. The most common dose recommended by the doctor is 10 / 10mg / time / day, equivalent to 10mg Atorvastatin and 10mg Ezetimibe / time / day. Patients should incorporate an appropriate lipid diet for the duration of treatment with Atorpa e. Conventional cholesterol-lowering therapy may be considered when initiating treatment with Atorpa e or adjusting the dose. Your doctor will evaluate factors, including: coronary heart disease risk, low-density lipoprotein cholesterol levels, and the patient's response to cholesterol-lowering therapy. Based on the test results and the patient's response to the lipid-lowering therapy being applied, the doctor will prescribe a specific dose. If it is necessary to adjust the dose of Atorpa e, the dose adjustment should be at least 4 weeks apart. Dosage for treatment of homozygous familial hypercholesterolemia:
Oral 10 / 10mg / day or 80 / 10mg / day. Atorpa e can be used as an adjunct to another lipid-lowering method (eg, LDL-removal) in this patient population.
Dosage of Atorpa e in combination with other drugs:
Atorpa e can be taken before 22 hours or after 24 hours after taking drugs that absorb bile acids. Coadministration of Atorpa e with hepatitis C antivirals containing Grazoprevir or Elbasvir. However, the dose of Atorpa e should not exceed 20/10mg/day. 3.2 How to use Atorpa e When starting to use Atorpa e, patients need to follow a cholesterol-restricted diet and maintain this regimen throughout the course of treatment. Because the drug is in the form of tablets, patients need to take it orally.
Atorpa e should be taken with filtered or boiled water instead of drinks containing alcohol, carbonated water or containing stimulants. Before taking the drug as well as during treatment with Atorpa e, patients should carefully read the instructions for use printed on the product packaging or follow detailed instructions from a specialist to ensure safety.
The dose of the drug should be taken exactly as prescribed, if necessary, it must be adjusted based on the patient's plasma lipid level. Treatment with Atorpa e should be started at the lowest effective dose, then consider increasing the dose at intervals of more than 4 weeks, while closely monitoring the response of the drug to the patient's body. , especially adverse reactions to the muscle system.

Side effects of Atorpa e may occur differently for each patient. Some side effects can be mild and not dangerous to the patient, but there are also symptoms that can easily leave health consequences if not treated promptly. Below are the side effects that patients are at risk of experiencing during treatment with Atorpa e:
Common side effects: Ankle edema, headache, flushing, dizziness, weakness, fatigue fatigue, feeling hot, shortness of breath, nausea, indigestion, abdominal pain, cramps, palpitations. Uncommon side effects: Excessive hypotension, chest pain, tachycardia, pruritus, rash, arthralgia, myalgia, sleep disturbance. Rare side effects: Urticaria, gingival hyperplasia, extrasystoles, hyperglycemia, elevated liver enzymes, confusion or erythema multiforme. When there are any suspicious symptoms after taking Atorpa e, the patient should quickly contact the treating doctor or immediately go to the hospital for diagnosis and effective treatment.

5.1 What precautions should be taken while taking Atorpa e? During treatment with Atorpa e, the following precautions should be taken by patients:
The use of certain lipid-lowering drugs, including Atorpa e, is only an interference with risk factors that increase the likelihood of atherosclerotic disease due to increased cholesterol in the blood. When treated with Atorpa e, patients should be applied together with a low-cholesterol, low-saturated fat diet and only use lipid-lowering drugs when not responding adequately to diet or non-pharmacological measures. other. Before using Atorpa e, it is necessary to rule out secondary causes of hypercholesterolemia, including hypothyroidism, uncontrolled diabetes, kidney failure, obstructive liver disease, dysproteinemia, alcoholism. ... In addition, patients also need to check blood lipids before deciding to treat with Atorpa e. Atorpa e should be used with caution in patients with aortic stenosis, decreased liver function or heart failure after acute myocardial infarction. Atorpa e may cause dizziness or ataxia, so patients should avoid driving or operating machinery while taking this medicine. 5.2 What drugs can Atorpa e interact with? In fact, there is a risk that Atorpa e may interact with a number of other drugs when used at the same time, including:
CYP3A4 enzyme inhibitors when taken with Atorpa e can increase blood levels interactions of the active ingredient Atorvastatin, thereby leading to a risk of myopathy and rhabdomyolysis. Concomitant use with Amiodarone may increase the risk of rhabdomyolysis. Therefore, patients should not take more than 20mg Atorvastatin/day to avoid this interaction. Coumarin derivatives when co-administered with Atorpa e may slightly increase the anticoagulant effect of Coumarin. For patients taking the blood thinner Coumarin, the prothrombin time should be determined before and during treatment with Atorvastatin. Caution should be exercised when combining Atorpa e with immunosuppressive drugs or Niacin. Concomitant administration of fibric acid derivatives, cyclosporin, Azol antifungals or erythromycin may increase the risk of myopathy. Approximately 35% reduction in Atorvastatin plasma concentrations was observed when Atorpa e was co-administered with antacids containing aluminum hydroxide or magnesium. An approximately 25% reduction in Atorvastatin plasma concentrations was observed when Atorpa e was co-administered with Colestipol. Increases plasma concentrations of Atorvastatin when co-administered with Protease inhibitors. To prevent an adverse reaction while taking Atorpa e, patients should inform their doctor about any other medications they are currently taking, including supplements, over-the-counter medicines, and supplements. multivitamins.

Reference source: drugbank.vn