Uses of Basicillin 100mg

1.1. What is Basicillin 100mg? Basicillin 100mg drug has the main active ingredient 100mg doxycycline base in the form of doxycycline hyclate and excipients just enough.
Basicillin 100mg is made in the form of hard capsules, packed in boxes of 10 blisters, each blister has 10 pills. The drug has the registration number GC-310-18, is a product of Medochemie (Far East) Co., Ltd.
1.2. What does Basicillin 100mg do? Basicillin 100mg drug containing doxycycline has been found to be clinically effective in the treatment of many diseases such as infections caused by susceptible strains of Gram-positive and Gram-negative bacteria and some other microorganisms.
Basicillin 100mg drug is used to treat a number of diseases such as:
Respiratory tract infections: Pneumonia and other lower respiratory tract infections. Pneumonia caused by Mycoplasma pneumoniae. Treatment of chronic bronchitis and sinusitis. Urinary tract infections such as those caused by susceptible strains of Klebsiella. Sexually transmitted diseases such as uncomplicated urethral, ​​cervical, or rectal infections. Non-gonococcal urethritis. Doxycycline is also indicated for syphilis, granulomatous and lymphogranuloma venereum. In fact, Doxycycline is an alternative medicine in the treatment of gonorrhea and syphilis. Skin infections: Acne-prone skin Eye infections: Basicillin 100mg Capsules are indicated in the treatment of trachoma. Rickettsial infections: Rocky Mountain spotted fever, typhus, Q fever, Coxiella endocarditis, and tick fever. Other infections: Other infections caused by susceptible strains of Yersinia species. Typhus, traveler's diarrhea (enterotoxin Escherichia coli), leptospirosis.

2.1. How to take Basicillin 100mg Tablets Basicillin 100mg should be swallowed with filtered water in a resting or standing position and before going to bed at night to reduce the possibility of irritation and ulceration of the esophagus.
Patients should take basicillin 100mg capsules after or with meals to avoid stomach irritation. Studies have shown that the absorption of basicillin is not significantly affected by concomitant ingestion of food or milk.
2.2. Dosage of Basicillin 100mg Adults and children from 12 years to under 18 years: The usual dose of Basicillin for the treatment of acute infections is 200mg. On the first day: single dose or divided into 12 hours. This is followed by a maintenance dose of 100mg per day. In the treatment of more severe infections (especially chronic urinary tract infections), 200mg per day is recommended for the duration of treatment.
Dosage recommendations in specific infections:
Acne: 50mg every 6 to 12 weeks. Sexually transmitted diseases: 100mg x 2 times a day. Acute epididymitis caused by Chlamydia trachomatis or Neisseria gonorrhoea: 100mg twice daily for 10 days. Primary and secondary syphilis: 300mg a day in divided doses for at least 10 days. Recurrent fever caused by lice and ticks: A single dose of 100mg or 200mg depending on the severity of the disease. Treatment of chloroquine-resistant falciparum malaria: 200 mg daily for at least 7 days. Quinine dosage recommendations vary in different regions. Malaria Prophylaxis: 100mg daily in adults and children over 12 years of age. Prophylaxis can be initiated 1-2 days prior to travel to malaria areas. To prevent typhus: 200mg as a single dose. To prevent traveler's diarrhea in adults: 200mg on the first day of travel (as a single dose or 100mg every 12 hours), then 100mg daily for the duration of your stay in the area. To prevent leptospirosis: take 200mg once weekly for the duration of your stay in the area and 200mg at the end of your trip. Children aged 8 to under 12 years
The use of Basicillin for the treatment of acute infections should be carefully considered.
For children 45 kg or less - Initial dose: 4.4 mg/kg (once or in 2 divided doses) with maintenance dose: 2.2 mg/kg (once or in 2 divided doses). In the treatment of more severe infections, a maximum of 4.4 mg/kg should be administered during the course of treatment. For children, over 45kg - Adult dose is recommended. Children from birth to under 8 years old.
Basicillin should not be given to children under 8 years of age due to the risk of tooth discoloration. Children: Not recommended. Elderly patients
Basicillin can be prescribed at the usual dosage without any special precautions. Renal impairment
Studies to date have shown that use of doxycycline at commonly recommended doses does not lead to excessive antibiotic accumulation in patients with renal impairment. Handling missed doses: If the patient forgets a dose of Basicillin, take it as soon as possible after remembering. But if it is too close to your next dose, skip the missed dose of Basicillin and take your next dose at the scheduled time. Patients should be careful not to double the prescribed dose.
Management of Overdose: Acute overdose of Basicillin with antibiotics is very rare. In case of overdose, gastric lavage is required and with appropriate supportive treatment as prescribed by a specialist. Hemodialysis does not alter the serum half-life and is therefore not beneficial in the treatment of overdose.

3.1. Contraindications Patients with hypersensitivity to active ingredients, active ingredients or any of the ingredients of the drug.
3.2. Other Drug Interactions The absorption of Basicillin 100mg may be impaired when co-administered with antacids containing aluminum, calcium, magnesium or other drugs containing these cations; zinc, iron salts or oral bismuth preparations. Because bacteriostatic drugs can interfere with the bactericidal activity of penicillins, the use of basicillin in combination with penicillins should be avoided. Basicillin 100 mg reduces plasma prothrombin activity and may require a dose reduction in concomitant anticoagulants. The serum half-life of Basicillin may be shortened when patients receive barbiturates, carbamazepine or phenytoin concomitantly. Some cases of pregnancy or sudden bleeding have been attributed to the concurrent use of tetracycline antibiotics with oral contraceptives. Concomitant use of Basicillin and methoxyflurane has been reported to lead to fatal nephrotoxicity. Concomitant use of isotretinoin or other systemic retinoids and Basicillin should be avoided. These agents used alone have been associated with benign intracranial hypertension. Ergotamine: Risk of exaggeration with concomitant administration of Basicillin and ergotamine. Methotrexate: Basicillin increases the risk of methotrexate toxicity. Physicians should prescribe caution to patients taking methotrexate. Quinapril contains magnesium carbonate and may interfere with the absorption of doxycycline.

Use with caution in the following cases:
Effects on ability to drive and use machines: Visual disturbances such as blurred vision may occur during treatment with doxycycline. In such cases, the patient should refrain from driving or operating machinery. Pregnancy: Basicillin is contraindicated during pregnancy. Nursing Mothers : Basicillin is excreted in breast milk and is therefore contraindicated in nursing mothers Children : Although the risk of permanent tooth discoloration is rare in children aged 8 to under 12 years. With age, the use of Basicillin should be carefully considered in cases where other drugs are not available, are not likely to be effective, or are contraindicated. Use in patients with impaired liver function: Basicillin should be used with caution in patients with hepatic impairment or those receiving potentially hepatotoxic drugs. Use in Patients with Renal Impairment: Studies have shown no significant difference in the serum half-life of doxycycline in subjects with normal and severely impaired renal function. The anti-anabolic effect of tetracyclines may increase blood urea nitrogen. Studies to date indicate that this anti-anabolic effect does not occur with the use of Doxycycline in patients with impaired renal function. Serious Skin Reactions: If serious skin reactions occur, doxycycline should be discontinued immediately and appropriate therapy instituted. In addition to the above cases, patients with a history of medical conditions should notify their doctor so that they can consider and prescribe appropriate drugs to avoid side effects of treatment that affect the risk of disease. .

Using Basicillin 100mg also has some side effects such as blurred vision, scotoma and double vision. Permanent loss of vision. Surface discoloration of permanent teeth has been reported with the use of Basicillin.

Store Basicillin in a cool, dry place, at a temperature not exceeding 30°C, in the original packaging and protected from light. Keep out of reach of children and away from household pets. Basicillin has a shelf life of 36 months from the date of manufacture. Basicillin is a prescription drug, so patients should not take it on their own without a prescription from a specialist. If the drug appears strange signs such as discoloration, deformation, watery, the patient should not use that medicine anymore. Do not use Basicillin after the expiry date printed on the blister pack, medicine box. Expired drugs should be discarded and disposed of according to regulations. Basicillin 100mg is an antibiotic with a broad spectrum of action that specializes in the treatment of infections of the respiratory tract, urogenital tract effectively. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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