Uses of Caricin

Caricin 500mg is commonly used in the treatment of some respiratory tract infections, skin and soft tissue infections,... So what is the use of Caricin 500mg and how is it used?

Caricin 500mg medicine contains the main ingredient is Clarithromycin 500mg. This is a semi-synthetic agent of Erythromycin A. This active ingredient binds to the 50S ribosomal subunit of susceptible bacteria and inhibits protein synthesis.
Clarithromycin is highly effective against gram-positive and gram-negative bacteria, both aerobic and anaerobic, specifically as follows:
Gram-positive bacteria: Streptococcus pyogenes (group A β-hemolytic streptococcus), Staphylococcus aureus , Streptococcus agalactiae, α-haemolytic streptococci (group of viridans), Streptococcus (Diplococcus) pneumoniae, Listeria monocytogenes. Gram-negative bacteria: Haemophilus parainfluenzae, Haemophilus influenzae, Helicobacter pylori, Moraxella (Branhamella), Neisseria gonorrhoeae, Legionella pneumophila, Bordetella pertussis, Campylobacter jejuni. Mycoplasma: Ureaplasma urealyticum, Mycoplasma pneumoniae. Anaerobic bacteria: Bacteroides fragilis is sensitive to Macrolid, Clostridium perfringens, Peptococcus species, Propionibacterium acnes. Other microorganisms: Mycobacterium avium, Mycobacterium fortuitum, Mycobacterium leprae, Mycobacterium kansasii, Chlamydia trachomatis, Mycobacterium chelonae, Mycobacterium intracellulare. The activity of Clarithromycin against H. pylori in neutral media was stronger than in acidic media.

Caricin 500mg is indicated in the following cases:
Lower respiratory tract infections: Acute and chronic bronchitis, pneumonia. Upper respiratory tract infections: Pharyngitis, sinusitis and otitis media. Mild to moderate skin and soft tissue infections. Community-acquired pneumonia. Peptic ulcers - duodenal bacteria H. pylori. Caricin 500mg is contraindicated in the following cases:
People with hypersensitivity to macrolide antibiotics. People who are being treated with Terfenadine.

Caricin 500mg is available as a film-coated tablet. You should take the tablet whole with a glass of water. Caricin can be taken before, after or with meals because food does not affect bioavailability.
Caricin 500mg dose should be according to the doctor's prescription. Reference dose in case of pathology is as follows:
Respiratory tract, skin and soft tissue infections: The usual dose is Caricin 250 - 500 mg x 2 times/day, for 6-14 days. Stomach and duodenal ulcers caused by H. pylori infection: Adults and the elderly use a dose of 500mg x 2 times/day, a 7-day course of treatment, in combination with other drugs. For patients with renal impairment: No dose adjustment is usually required unless the patient has severe renal impairment (creatinine clearance less than 30 ml/min). If necessary, the total daily dose should be halved. Overdose of Caricin 500mg can cause gastrointestinal symptoms such as abdominal pain, nausea, vomiting and diarrhea. Symptoms of overdose should be treated with gastric lavage and supportive therapy. As with other macrolide antibiotics, serum concentrations of clarithromycin are not altered by hemodialysis or peritoneal dialysis.
If you forget a dose of Caricin 500mg, take the extra dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your dosing schedule. Do not use a double dose to make up for a missed dose.

When using Caricin 500mg you may experience side effects of the drug. Common side effects of Caricin 500mg include:
Digestive disorders, especially in children with a frequency of 5%. Allergic reactions of varying degrees from urticaria to anaphylaxis and Stevens-Johnson syndrome (rare). Pseudomembranous colitis ranges from mild to life-threatening. Systemic side effects: Hypersensitivity reactions such as itching, skin rash, urticaria, irritation. Rare side effects of Caricin 500mg include:
Cholestatic symptoms such as upper abdominal pain, sometimes severe pain, nausea, vomiting. Abnormal liver function, elevated serum bilirubin and often accompanied by jaundice, typhus, and polyeosinophilia. Deafness if used in high doses, the auditory nerve can be restored. Inform your doctor about the side effects you experience when using Caricin 500mg.

As with other macrolide antibiotics, concomitant use of Caricin with drugs metabolised by the cytochrome P450 system (e.g., Warfarin, Lovastatin, Argot alkaloids, Triazolam, Disopyramid, Phenytoin and Cyclosporin) may increase serum concentrations of these drugs. Administration of Caricin to patients receiving Theophylline will increase serum theophylline concentrations and increase the potential for theophylline toxicity. The use of Caricin in patients taking Warfarin may potentiate the effects of Warfarin. Prothrombin time should be regularly monitored in these patients. The effectiveness of Digoxin may be increased when used concurrently with Caricin. Caricin may increase the potency of Carbamazepine by decreasing the rate of excretion. Macrolide antibiotics have been reported to alter the metabolism of terfenadine, causing increased concentrations of terfenadine. This condition is associated with cardiac arrhythmias and therefore Caricin should be avoided in patients receiving terfenadine and any related non-sedating antihistamines such as Astemizol. Concomitant administration of caricin with zidovudine to HIV-infected adult patients may decrease steady-state zidovudine concentrations. Most can avoid this by taking Caricin and Zidovudine about 1-2 hours apart. No similar reactions have been observed in children. Plasma concentrations of Clarithromycin and Omeprazole may be increased when used concurrently, but no dosage adjustment is required. Clarithromycin plasma concentrations may be increased when used concomitantly with Maalox or Ranitidine. However, in this case, no dosage adjustment is required.

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