Uses of Cendagyl

Cendagyl medicine contains the main ingredients Spiramycin and Metronidazole. Each ingredient has different effects. Specifically:
The ingredient Spiramycin in the drug is known to be a macrolide antibiotic but has a broader antibacterial spectrum and stronger potency than erythromycin. Spiramycin has a different degree of activity against each strain of bacteria:
Some bacteria are usually susceptible to Spiramycin such as: Streptococcus, Staphylococcus susceptible to methicilline, Rhodococcus equi, Branhamella catarrhalis, Bordetella pertussis, Helicobacter pylori, Campylobacter jejuni, Corynebacterium diphteriae, Moraxella,... Moderately sensitive bacteria such as: Neisseria gonorrhoeae, Vibrio, Ureaplasma, Legionella pneumophila... Infrequently susceptible strains: Streptococcus pneumoniae, Enterococcus, Campylobacter coli, Peptostreptococcus, Clostridium perfringens. Resistance: Meticillin-resistant Staphylococcus, Enterobacteriaceae, Pseudomonas, Acinetobacter, Nocardia, Fusobacterium, Bacteroides fragilis, Haemophilus influenzae and para-influenzae. Spiramycin is rapidly absorbed and unaffected by food. But not completely absorbed. Spiramycin is well diffused in saliva and tissues. When 6 million units are taken orally, this ingredient will reach a maximum blood concentration of 3.3mcg/ml, equivalent to a half-life of 8 hours. Spiramycin does not pass through the cerebrospinal fluid, through breast milk. .
Ingredients Spiramycin metabolized in the liver but slowly. The major route of elimination for Spiramycin is via the bile, to a very limited extent in the urine and faeces.
Besides, the ingredient Metronidazole is known to be an antibacterial drug of the nitro-5 imidazole family. According to research, this ingredient has a good effect on both the amoeba inside and outside the intestines, both acute and chronic. However, with chronic intestinal amoebic dysentery, the effect of Metronidazole will be weaker.
Bacteria often sensitive to Metronidazole such as: Trichomanas vaginalis, Giardia, gram-negative anaerobes including Bacteroides, Clostridium, Helicobacter. Aerobic bacteria strains are not sensitive to this component. Metronidazole after entering the body will be quickly absorbed after 1 hour. Peak plasma concentrations of metronidazole by oral and parenteral routes are similar at equivalent doses. This ingredient is not affected by food. Metronidazole crosses the placental barrier and passes into breast milk, therefore, pregnant or lactating women should use caution. Metronidazole is rapidly and strongly diffused into tissues and fluids, even the cerebrospinal fluid. The major organ of metabolism of Metronidazole is in the liver. This component is excreted mainly in the urine, less in the feces.

In cases of prevention and treatment of oral infections, the patient will be prescribed Cendagyl. Specifically:
For prevention: There are complications of local infection after dental-oral surgery. For the treatment of acute or chronic or recurrent oral sinus infections: Dental abscess, inflammation, gingivitis, stomatitis, inflammation of the subcutaneous tissue and mandibular salivary glands, periodontitis, peritonitis Teeth, parotid gland inflammation... Cendagyl is contraindicated in the following cases:
Patients with hypersensitivity to any ingredient of the drug Children under 6 months of age Contraindicated to use Cendagyl with alcohol , Disulfiram, alcohol-containing drugs.

3.1. How to use Cendagyl is prepared in the form of film-coated tablets that should be administered orally. Patients should carefully read the instructions for use of the drug before using it to increase the effectiveness of the drug treatment. When taking the drug should take the pill whole, do not crush or break it.
Absolutely drink alcoholic drinks or juices with medicine.
3.2. Dosage Patients need to follow the dosage instructions from the doctor. Do not arbitrarily adjust the dose or stop taking the drug suddenly. The dose of the drug will be adjusted by the doctor based on the purpose of treatment, the age and condition of the patient. You can refer to the dosage below:
For prophylactic use
Children 6-10 years old: Take 2 tablets per day. Children 10-15 years old: Take 3 tablets per day. Adults: Take 4-6 tablets per day, divided into 2-3 times. For therapeutic dose
Children 6-10 years old: Take 2 tablets per day. Children 10-15 years old: Take 3 tablets per day. Adults: Take 4-6 tablets per day, divided into 2-3 times. In severe cases, it can be increased to 8 tablets/day. Using the wrong dose of the drug has a significant effect on the drug's activity. This condition can cause the drug to decrease the mechanism of action, leading to not completely treating the symptoms of the disease. If you forget to take a dose, take it as soon as you remember. In case it is almost time for the next dose, skip the missed dose and take the next dose as scheduled;
Using Cendagyl drug overdose can cause symptoms such as: Nausea, vomiting, diarrhea ... At that time, the patient should actively notify the doctor if he or she realizes that he has used more than the recommended dose. fox. Usually, the doctor will prescribe the treatment of overdose with symptomatic treatment.

Cendagyl drug can cause side effects during use. The cause of this condition is caused by both the active ingredients Spiramycin and Metronidazole.
Some side effects caused by Spiramycin such as: Nausea, vomiting, stomach pain, diarrhea and very rarely cause pseudomembranous colitis, Quincke's edema, anaphylaxis, even hemolytic anemia. Some side effects caused by Metronidazole such as: Confusion, hallucinations, epigastric pain, diarrhea, dry mouth, metallic taste in mouth, loss of appetite, urticaria, Quincke's edema, less likely to cause anaphylaxis... The above are not all side effects of Cendagyl. Therefore, during the course of drug treatment, patients experiencing any unusual signs should notify their doctor to receive timely treatment measures.

It has been noted that Cendagyl can cause some interactions with other drugs such as: Levodopa, Disulfiram, Oral Anticoagulants, Fluorouracil, Treponema
Therefore, to avoid this situation, you should actively make a list medications you are taking (including prescription, over-the-counter, herbal and dietary supplements) and show them to your doctor or pharmacist.

To use the drug safely, patients should note the following:
Metronidazole and Spiramycin ingredients can be used for women in pregnancy. Only use this medicine for patients who are breast-feeding if prescribed by a doctor. Because 2 components of Cendagyl can be excreted in milk. Cendagyl may significantly affect the patient's ability to drive and use machines. The following subjects should be cautious when using the drug: people with glucose-6-Phosphat-Dehydrogenase deficiency, leukopenia... There have been some cases of patients using the drug for a long time, causing adverse effects.

Carefully read the instructions for storing the medicine on the box and read the instruction sheet for the medicine. Before using, check the expiry date of the medicine. When not in use, the drug should be collected and disposed of according to the instructions of the manufacturer or those in charge of the medical field. Store the drug in a cool, dry place, avoid direct sunlight or high temperature, it can convert the ingredients in the drug. The above information is for reference only, in order to maximize the effectiveness of treatment, patients need to use Cendagyl exactly as directed by their doctor. Absolutely do not arbitrarily use without the prescription of a specialist.