Uses of Compazine

Compazine drug with the main active ingredient is Prochlorperazine, indicated in the symptomatic treatment of nausea, vomiting, schizophrenia and as an aid in the management of anxiety. So what are the uses, usage and precautions when using Compazine?

Compazine drug has the main active ingredient is Prochlorperazine, which has weak anticholinergic effects, moderate sedative effects, strong extrapyramidal effects and strong antiemetic effects. Prochlorperazine antagonizes dopamine-mediated neurotransmission at synapses and may block postsynaptic dopamine receptors. The antiemetic effect of the drug is due to its direct action on the chemoreceptor activating region of the marrow by blocking dopamine receptors. Compazine is indicated for the symptomatic treatment of nausea and vomiting of any etiology, schizophrenia, acute mania, and as an aid in the management of anxiety. The drug should not be used to treat behavioral problems in older adult patients with dementia.

Treatment of severe nausea and vomiting:
Adults and children 2 years of age and older and weighing more than 39kg: It is recommended to start with 5 or 10 mg, 3 or 4 times a day. Your doctor can adjust your dose if needed. However, the dose is usually no more than 40 mg per day. Children 2 years and older and weighing 18 to 39kg: Dosage is based on body weight and must be determined by a doctor. May start with 2.5 mg x 3 times a day or 5 mg x 2 times a day. Dosage is usually no more than 15 mg per day. Children 2 years of age and older and weighing 14 to 18 kg: Initial dose is 2.5 mg x 2 or 3 times a day, maximum dose not to exceed 10 mg per day. Children 2 years of age and older and weighing 9 to 13 kg: Initial dose is 2.5 mg x 1 or 2 times a day, maximum dose not to exceed 7.5 mg per day. Children under 2 years of age and weighing less than 9kg: Compazine should not be used. Treatment of non-psychotic anxiety:
Adults: Initial dose is 5 mg x 3 or 4 times a day, maximum dose not to exceed 20 mg every day or for more than 12 weeks. Children: Use and dosage must be determined by a specialist. Treatment of schizophrenia:
Adults: Initial dose is 5 to 10 mg x 3 or 4 times a day, maximum dose not to exceed 150 mg per day. Children 6 to 12 years: Start with 2.5 mg x 2 or 3 times a day, maximum dose not to exceed 10 mg on first day and 25 mg daily. Children 2 to 5 years: Start with 2.5 mg x 2 or 3 times a day, up to a maximum of 10 mg on the first day and 20 mg daily. Children under 2 years: Use and dosage must be determined by a specialist.

Patients using Compazine may experience side effects including:
Cardiovascular: Electrocardiogram abnormalities, orthostatic hypotension, peripheral edema Dermatology: Contact dermatitis, eczema, skin erythema , exfoliative dermatitis, pruritus, skin pigmentation, urticaria Endocrine and metabolic: Amenorrhea, bleeding unrelated to childbirth, gynecomastia, hyperglycemia or hypoglycemia, weight gain Gastrointestinal: Colon atony, cholestasis, constipation, increased appetite, intestinal obstruction, nausea, constipation, vomiting, flatulence Genitourinary system: Ejaculatory dysfunction, urinary tract, impotence, urination pain, urinary retention Hematology: Aplastic anemia, eosinophilia, hemolytic anemia, leukopenia Liver: Cholestatic jaundice Hypersensitivity: Anaphylaxis Nervous system: Agitation, anticholinergic syndrome, coma, confusion, decreased cough reflex, dizziness, somnolence, headache, restlessness, motor dysfunction, restlessness Neuromusculoskeletal: Lupus-like syndrome Eyes: Blurred vision, epidermal keratosis tissue, mydriasis, retinitis pigmentosa Respiratory: Throat edema larynx, stuffy nose

In the process of using Compazine, patients should pay attention to the following issues:
Be careful when using Compazine with alcohol or other drugs affecting the central nervous system. Concomitant use of alcohol or other drugs that affect the central nervous system may worsen the side effects of the drug, such as dizziness, poor concentration, drowsiness, unusual dreams and difficulty sleeping. Some examples of drugs that affect the CNS are antihistamines, cold or allergy medicine, tranquilizers, sleeping pills, antidepressants, anxiety medications, and pain relievers. prescription drugs, narcotics, attention-deficit/hyperactivity disorder medications, seizure medications, muscle relaxants, or anesthetics, including some dental anesthetics. Compazine may cause extrapyramidal symptoms. Contact a physician immediately if patient experiences difficulty speaking, drooling, loss of balance control, muscle tremors, jerks or stiffness, restlessness, cluttered gait, stiffness in the limbs, or motionlessness. control, especially the face, neck and back. Compazine can cause drowsiness, trouble thinking, or difficulty controlling body movements, which could lead to falls, broken bones, or other injuries. Patients should be especially careful when driving, using machines, or doing other tasks that require alertness. Dizziness, lightheadedness, or fainting may occur, especially when the patient suddenly gets up from a lying or sitting position. Standing up slowly can be helpful for the patient. If the problem continues or gets worse, see your doctor for a checkup. Compazine can make it harder for the body to cool down. Care should be taken when exercising heavily or the weather is very hot, as this can lead to heatstroke. Compazine may affect the results of certain medical tests. Compazine may cause tardive dyskinesia. Contact a doctor immediately if a patient has any of the following symptoms while using this medicine: pursed lips, bulging cheeks, uncontrolled chewing movements, or uncontrolled movements of the arms and legs. Patients should see a doctor if they have any of the following symptoms while taking this medicine: convulsions (seizures), shortness of breath, rapid heartbeat, high fever, increased sweating, loss of bladder control, blood high or low pressure, severe muscle stiffness, unusually pale skin, or fatigue. The above signs may be symptoms of a serious condition called neuroleptic malignant syndrome. Prochlorperazine may temporarily lower a patient's blood white blood cell count and increase the likelihood of infection. Therefore, patients should avoid infected people to prevent infection. In addition, patients should seek medical attention if they have a fever or chills, cough or hoarseness, lower back or side pain, painful or difficult urination. Elderly: Elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require an adjustment in the dose of Compazine. Lactation: There are no adequate studies in nursing women to determine the risk in the infant when the mother uses Compazine. The benefits should be weighed against the possible risks before taking Compazine while breast-feeding. Pregnancy: Use of antipsychotics during the third trimester of pregnancy carries a risk for abnormal muscle movements and withdrawal symptoms in the neonate after birth. Symptoms in infants may include agitation, feeding disturbances, hypertonia, hypotonia, respiratory distress, somnolence, and tremors; These effects may be self-limited or require hospitalization. The use of Prochlorperazine may be considered for the adjuvant treatment of nausea and vomiting in pregnant patients when symptoms persist after initial drug therapy. Above is information about uses, usage and notes when using Compazine. Patients should not self-medicate, but should consult a doctor or pharmacist before using.
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References: webmd.com, drugs.com