Uses of Corcotab

Corcotab is a drug belonging to the group of cardiovascular drugs, with the main ingredient being Bisoprolol fumarate 2.5mg, prepared in the form of film-coated tablets, packaged in boxes of 2 blisters or 5 blisters, each blister contains 14 tablets. To understand more information about the drug Corcotab in the treatment of hypertension, read the following article.

Corcotab has the main ingredient is Bisoprolol drug, prepared in tablet form, drug content 2.5mg.
Mechanism of action: Bisoprolol is a beta-adrenergic receptor blocker, thereby blocking the sympathetic nervous system on the heart. Cardiac selective drug without ISA, reducing heart rate and lowering blood pressure. Bisoprolol reduces the need for oxygen by the heart, so Corcotab is effective in the treatment of angina (which occurs when the demand for oxygen exceeds the supply) and the treatment of tachycardia. Bisoprolol is almost completely absorbed from the gastrointestinal tract after oral administration (approximately 90%). Maximum blood concentrations are generally reached after 1-2 hours. Bioavailability of the drug is high, reaching 85-90%. The drug is about 30% bound to plasma proteins, crosses the placenta and is excreted in breast milk. The drug is metabolized in the liver parenchyma, excreted almost completely by the kidneys in the urine.

2.1. Indications Corcotab is effective in mild and moderate hypertension. Used as monotherapy or in combination with other classes of antihypertensive drugs, especially diuretics. Diseases of the heart: including angina, as an aid in the treatment of chronic heart failure. 2.2. Contraindications Do not use Corcotab in the following conditions:
Allergy to Bisoprolol, other beta-blockers or other ingredients contained in the drug. Cardiogenic shock, decompensated heart failure. Atrioventricular conduction disturbances (also called second and third degree AV block), sinus node disorder, sinoatrial block. Bradycardia less than 50 beats in 1 minute before starting medication. Patients with low blood pressure, systolic blood pressure readings less than 90 mmHg. Respiratory diseases such as Bronchitis, asthma, chronic respiratory diseases. Corcotab should not be used concomitantly with MAO inhibitors. The patient has an active peripheral circulatory disorder. Raynaud's syndrome, the patient is suffering from metabolic acidosis.

How to use: Patients take Corcotab tablets whole with a glass of water. Do not arbitrarily break in half, crush, drink at a specified time of day.
Dosage: Dosage is determined according to each patient in accordance with heart rate and clinical results.
In the treatment of hypertensive and angina pectoris: Recommended dose: a single dose of 5 to 10 mg per day.
The maximum daily dose is 20mg.
No dose reduction is necessary in patients with mild to moderate hepatic dysfunction and renal impairment. In case of severe decline in kidney and liver function, the daily dose should not exceed 10 mg.
Corcotab dosage in heart failure: Initial dose: 1.25 mg orally once a day. If well tolerated, the dose can be increased to 2.5 mg after 1 week, and gradually increased over 1-4 weeks to the maximum dose tolerated by the patient, not to exceed 10 mg/day. .
Do not adjust the dose in elderly patients except in cases of significant impairment of liver and kidney function.
In case of overdose:
Common signs of drug overdose are bradycardia and hypotension. Bisoprolol should be discontinued immediately, treatment with intravenous atropine 1 to 2 mg. In severe cases, a further intravenous dose of 25 mcg of isoprenaline can be given, glucagon can be used in doses of 1 to 5 mg.
Other common signs, such as bronchospasm and heart failure, require intravenous administration of aminophylline to reduce spasm and treat with digitalis and diuretics.

Depending on the frequency of clinical symptoms when using, side effects of Corcotab include:
Common: body fatigue, dizziness, headache, sweating, signs sleep disturbances, anxiety, decreased attention and depression. These symptoms are less severe and disappear within 1 to 2 weeks after starting drug treatment. Occasionally: Gastrointestinal disturbances including diarrhea, constipation, nausea/vomiting, abdominal pain, epigastric pain, or gastric ulcer...Other symptoms such as hypotension, bradycardia, or atrioventricular conduction disturbances and numbness, cold sensation in the extremities. Rare: skin reactions (eg, erythema, skin swelling, itching, hair loss...), myasthenia gravis, decreased lacrimation, dyspnoea in patients with a predisposition to bronchospasm. In patients with a limp, Raynaud's phenomenon, at the beginning of the drug, these symptoms may be more severe and signs of myocardial failure may be more severe. In elderly patients with diabetes, signs of hypoglycemia such as heart palpitations may be masked. Laboratory indicators: hypertriglyceridemia, slight increase in uric acid, BUN, creatinine, blood potassium, glucose, phosphorus, slight decrease in white blood cells and platelets. This change in blood tests is of no clinical significance and rarely requires discontinuation of Corcotab..

Notes when taking Corcotab include:
Inform the treating doctor about your medical history so that the doctor can consider taking the drug. History of heart failure, or bronchospasm, the patient should be considered and cautious if taking the drug. The use of the drug should not be stopped suddenly, as it may cause an exacerbation of angina or the pain of myocardial infarction, ventricular arrhythmias in patients with coronary artery disease. The drug should be discontinued at least 48 hours prior to surgery. If medication is used during surgery, caution should be exercised with anesthetic agents such as ether, cyclopropane or trichlorethylene. In case of overdose, treat with atropine 1-2 mg dose. Medicines to mask hypoglycemia (tachycardia). However, in diabetics taking insulin or oral hypoglycemic agents, Bisoprolol should be used with caution. Bisoprolol may mask clinical symptoms of hyperthyroidism including tachycardia. Abrupt discontinuation of Corcotab may trigger an episode of thyrotoxicosis. Corcotab should not be used by women who are pregnant or breastfeeding. Because the drug can cause bradycardia, hypotension or hypoglycemia in the neonate, the mother must be discontinued 72 hours before the due date of delivery. If the drug is not discontinued, the infant must be monitored for 48 to 72 hours after birth. The drug has a hypotensive effect, which depending on the individual may affect the ability to drive a vehicle or operate machinery. This condition is especially common at the time of initiation of treatment and when there is a change in medication use or drug interactions with alcohol. Above is an informational article about the drug Corcotab. Corcotab drug is used in cardiovascular diseases , antihypertensive effect, used when prescribed by a doctor. Patients should adhere to treatment, avoid arbitrarily quitting, stopping abruptly to avoid unwanted side effects. For all questions and concerns, please consult a doctor or a qualified physician.