Uses of Dafidi

Dafidi drug is commonly used in the treatment of mental disorders. To know how the drug is used and what precautions should be taken when using it, please read the information in the following article.

Dafidi drug contains the main active ingredient Clozapine and excipients just enough such as Avicel, Lactose, Povidone, Talc, Magnesium Stearate,...
Active ingredient Clozapine, which is a derivative of Benzodiazepine, belongs to the group of anti-inflammatory agents. 2nd generation atypical psychosis. At present, the mechanism of action of this active substance has not been completely elucidated, however, many documents show that the process of promoting the effectiveness of Clozapine involves the participation of various conduction systems. CNS and especially Dopaminergic transmission in the inflammatory region. Due to its ability to antagonize alpha-Adrenergic receptors, Clozapine will help sedation, muscle relaxation as well as bring a number of other effects on the cardiovascular system.
The biggest difference of Clozapine with other antipsychotics is that it causes less extrapyramidal effects, reduces the ability to secrete Prolactin, so it avoids some side effects on health.

2.1. Indications to use Dafidi With the above effect, Dafidi drug is commonly used in the treatment of neurological diseases such as:
Patients with schizophrenia resistant to other antipsychotic drugs. People with mental disorders during Parkinson's treatment. 2.2. Contraindications to use Dafidi drug Dafidi drug is contraindicated in the following cases:
People with difficult-to-treat epilepsy. Patients with myelosuppression or are taking bone marrow suppressing drugs to treat the disease. People with agranulocytosis syndrome or a history of this disease. Patients with severe heart disease, circulatory failure, paralytic ileus. People with psychotic syndrome related to alcohol, acute liver failure jaundice, severe renal failure or hypersensitivity to the components of the drug.

3.1. Dosage of Dafidi Depending on the disease that needs to be treated, you can refer to the dose of Dafidi as follows:
People with treatment-resistant schizophrenia:
Day 1: Use with a dose of 1/2 tablet/time x1-2 times/day. Day 2: Use with dose of 1-2 tablets/time x 1-2 times/day. Thereafter, you need to gradually increase to 1-2 tablets/day until a therapeutic response is achieved. Note that the maximum use of the drug is 12 tablets / day, divided into several doses. Higher doses of Dafidi can be used at bedtime.
Meanwhile, the maintenance dose should be used at the lowest level and at the end of treatment, the dose should be reduced gradually over a period of about 1-2 weeks before stopping the drug completely.
Control psychosis, agitation during Parkinson's treatment:
Starting dose of 1/2 tablet/day (before going to bed). After that, the dose can be gradually increased 2 times a week, each time increasing by 1/2 tablet. The maximum dose of Dafidi is 2 tablets / day. In case of need, it may be considered to increase to 4 tablets / day, divided into 2 doses. Note: Elderly patients over 60 years old should only use Dafidi at a low dose (1 tablet/day).
3.2. How to take Dafidi You can use Dafidi at any time of the day (regardless of the meal). However, to avoid missing a dose, take it at a certain time.

During the use of Dafidi, patients may experience some of the following side effects:
Cardiovascular effects: Increased heart rate, increased or decreased blood pressure, chest pain,... Effects on nerves Central: Causes dizziness, insomnia, headache, depression, anxiety,... Effects on skeletal muscle: Causes muscle tremors, muscle weakness, muscle pain,... Affects on the digestive tract: Causes constipation, nausea, vomiting, increased salivation, loss of appetite,... Effects on respiration: Causes shortness of breath,... Effects on urinary - genitals: Causes male gender premature or slow ejaculation, urinary retention, impotence,... Effects on hematology: Decrease white blood cells, agranulocytosis,... Effects on liver: Causes abnormal liver function. Skin Effects: Skin rash. Effects on eyes: Decreased visual acuity, decreased vision. In addition to the above common symptoms, the patient may have a number of other unusual problems. At this point, you need to notify your doctor for timely advice.

Dafidi can interact with some of the following drugs:
When using together with drugs that inhibit bone marrow such as Chloramphenicol, Penicilamin, anti-cancer, ... will increase bone marrow suppression excessively. Taking Dafidi in combination with Droperidol will increase cardiotoxicity. Concomitant use with benzodiazepines will increase circulatory depression causing cardiac arrest, respiratory arrest. Inducers of CYP450 have the potential to decrease Dafidi blood levels and decrease its efficacy. Dafidi will also increase the effects and toxicity of anticholinergic drugs, some antihypertensive drugs.

Adhere to the correct dose when using the drug, using a dose of more than 100 tablets will cause death in adults. Particularly for small subjects, only a dose of 2-8 tablets can cause severe toxicity. Therefore, in the event of an overdose, the patient needs immediate medical attention. Dafidi can cause dizziness and lightheadedness, so patients should absolutely not drive after taking the drug. Pregnant and lactating women consult their doctor before taking Dafidi. Above is some information about Dafidi drug that readers can refer to. This is a prescription drug, so users should note that it should only be used when prescribed by a doctor.