Uses of Damrin

Diacerein is known as an anti-osteoarthritis drug, achieving high efficiency in anti-inflammatory tumors and treatment of degenerative joint diseases such as osteoarthritis and many related diseases. The drug is well tolerated in the stomach because it does not cause inhibition of prostaglandin synthesis. On the other hand, this is the only drug currently available among anti-osteoarthritis drugs that achieves the ability to affect both the anabolism and catabolism of chondrocytes and to limit proinflammatory factors.
Based on the results of many in-vitro and in-vivo studies, it has been shown that Rhein and Diacerein, its active metabolite, inhibit the production and activity of the eytokine IL-1b. proinflammatory and pro-catabolic. Affects both superficial and deep layers of cartilage, in synovial fluid and synovial membrane. On the other hand, it also stimulates transforming growth factor (TGF-α) and components of the extracellular matrix such as hyaluronic acid, aggrecan, proteoglycan and type II colloid.

2.1. Dosage of Diacerhein is recommended to be used with a specific dose for each specific group of subjects as follows:
For patients with Gout: Use 200-400mg per day, equivalent to a dose of 1-2 tablets, divided into 2-4 times a day. Use with a maximum dose of 600 - 800mg, equivalent to 3 - 4 tablets per day. For patients with secondary hyperuricemia: Use 200-400mg per day, equivalent to a dose of 1-2 tablets, divided into 2-4 times a day. For patients to prevent increased uric acid in chemotherapy: Use 600-800mg daily, equivalent to a dose of 3-4 tablets, divided into 2 oral doses during the day. Dosage for children:
Dosage for children under 6 years old: 150mg per day, equivalent to a dose of 3⁄4 pills, divided into 3 times a day. Dosage indicated for children from 6 to 15 years old: 300mg per day, equivalent to 1.5 tablets, divided into 3 times a day. 2.2. How to use The drug is in the form of a capsule, so patients should take it orally. Should be taken after meals with a full glass of warm water, swallowed whole, do not chew or break the medicine before use.
In addition, during the course of using the drug, the patient should strictly follow the instructions and instructions of the doctor, absolutely do not research and adjust the dose to achieve their own desires.
2.3. Handling when forgetting dose, overdose Damrin In case of forgetting to take a dose of medicine, the patient should not be too worried, instead, take the supplement as soon as you remember (usually 1-2 hours from the time you take it). according to the plan). However, if it is almost time for your next dose, you can skip the missed dose and continue taking your next dose as directed by your doctor.
Currently, there is no record of overdose when using the drug, but patients should monitor the body's manifestations when taking an overdose. If strange phenomena are detected, it is necessary to immediately notify the doctor or go to the nearest medical facility for timely and appropriate treatment instructions.

3.1. Contraindications Damrin is contraindicated in the following subjects:
Patients with a history of allergy or hypersensitivity to Diacerein or any active ingredient or excipient in the drug. Patients with a history of allergy, hypersensitivity to anthraquinone derivatives. 3.2. Side effects During the use of Damrin, patients are at risk of experiencing some unwanted side effects below:
Increases the time it takes for food to pass through the intestines and causes discomfort, abdominal pain. These symptoms may occur during the first few days of treatment, but they will subside on their own and disappear in the following days. Causes urine to be a darker yellow than usual. When experiencing any signs of side effects when taking the drug, the patient should immediately notify the doctor for the safest treatment.
3.3. Precautions When using the drug, patients need to pay special attention to the following important issues:
Should not be used in children under 15 years of age, because there are no clinical studies for this age group. Do not use the drug concurrently with drugs with a laxative effect. Care should be taken when using Damrin with some of the following drugs: Drugs containing salts, aluminum hydroxide, oxides, magnesium or calcium... Because they can reduce the absorption of Diacerein. In cases where it is imperative to take both drugs at the same time, the patient should take them at different times (at least 2 hours apart after taking Diacerein). Diacerein should not be used by women who are pregnant or breastfeeding. Because according to many reports, it has been shown that there is still a small amount of diacerein derivatives that can pass into breast milk and affect the fetus. 3.4. Some other notes Because Diacerein brings about a rather slow effect and the effect is evident after about 2-4 weeks of treatment. Therefore, patients should be persistent in taking the drug, should not stop treatment when the effect is not clear. Diacerein does not inhibit prostaglandin synthesis and is not harmful to the stomach, so during the first 2-4 weeks of treatment it can be safely prescribed to a non-steroidal anti-inflammatory drug (NSAID). Renal impairment may alter the pharmacokinetics of diacerein, so a dose reduction as directed by the physician is required in these cases. Above is information about the uses of Damrin as well as its composition, dosage and important notes when using it. However, to ensure safety, patients should still consult and follow the doctor's instructions.