Uses of Decirid 81mg

Name of the drug: Decirid 81 mg
Category: Painkiller, antipyretic, anti-inflammatory
SDK: VD-33800-19 manufactured by USpharma Hanoi - VIETNAM Joint Stock Company.
Ingredients : Decirid 81 mg contains Aspirin 81mg
Dosage form: Enteric film coated tablets

2.1 Indications Decirid 81mg is indicated for use in the following cases:
Reduce the risk of cardiovascular death in patients with suspected acute myocardial infarction. Reduce the risk of a first non-fatal myocardial infarction in patients considered by the physician to be at sufficient risk for this event. There is no evidence for a reduced risk of first fatal myocardial infarction. Aspirin does not reduce the risk of cardiovascular death and first-time stroke with or without death. The reduction in the risk of nonfatal first-time myocardial ischemia must be assessed based on a small but insignificant increase in the risk of hemorrhagic stroke as well as gastrointestinal bleeding. Reduced risk of morbidity and mortality in patients with unstable angina, in patients with prior myocardial infarction. Reduced risk of transient ischemic attack (TIA) and secondary prevention of atherosclerotic cerebral infarction. Prophylaxis of venous thrombosis after total hip replacement. 2.2 How to use - Dosage of the drug Decirid 81Mg How to use:
Should take the drug after meals with a glass of water.
Dosage:
Suspected acute myocardial infarction
Initial dose of at least 162mg, chew or drop tablets to ensure rapid absorption immediately after myocardial infarction is suspected. This dose level should be maintained for 30 days. After 30 days, follow-up therapy should be considered based on dose and administration to prevent recurrent myocardial infarction.
Prevention of first non-fatal myocardial infarction
Use 81 - 325mg x 1 time / day, depending on the needs of each patient and prescribed by the doctor, Have had a previous myocardial infarction or angina unstable chest: 81 - 325 mg x 1 time / day, depending on the needs of each patient and prescribed by the doctor.
Reduced risk of transient ischemic attack (TIA) and secondary prevention of atherosclerotic cerebral infarction
Use 81 - 325 mg once daily, depending on individual patient needs and as directed by physician determined.
Prophylaxis of venous thrombosis after total hip replacement
Use 162 – 325mg x 1 time/day, depending on the needs of each patient and prescribed by the doctor.
Note: The above dosage is for reference only. The specific dose depends on the condition and the progression of the disease. To get the right dose, you need to consult your doctor or healthcare professional.
2.3 Missed dose - Overdose and management Symptoms
Mild overdose or early stages of poisoning: Hot mouth, lethargy, nausea, vomiting, ringing in the ears, sweating, thirst, rapid or rapid heartbeat face. Moderate Overdose: All symptoms of mild overdose plus tachypnea, high fever, sweating, dehydration, loss of coordination, restlessness, mental confusion. Severe Overdose: All symptoms of moderate overdose plus hypotension, hallucinations, stupor, hypoglycemia, convulsions, cerebral edema, oliguria, renal failure, heart failure, coma, hemorrhage, metabolic acidosis, respiratory alkalosis or respiratory failure. Emergency treatment
Immediately transfer to hospital and maintain cardiovascular and respiratory support. Rinse the stomach, give activated charcoal. Check acid-base balance and adjust acid-base balance if necessary. Alkaline diuretics should be considered to obtain a urine pH between 7.5 and 8 when plasma salicylates are greater than 500 mg/l (3.6 mmol/l) in adults or 300 mg/l (2.2 mmol/l) l) in children. Hemodialysis should be considered in cases of severe poisoning of 800 mg/l (5.8 mmol/l) in adults and 700 mg/1 (5.0 mmol/l) in children, as renal clearance of salicylates may be possible. delayed by acidic urine and by renal failure. Hemodialysis should also be considered in patients with severe systemic metabolic acidosis (arterial pH <7.2), acute renal failure, pulmonary edema, or CNS symptoms such as: Drowsiness, agitation, coma or convulsions. The loss of fluid should be replaced with a hypotonic solution (e.g. 0.45% NaCl solution) and 50-100 g/l glucose supplementation. Symptomatic treatment
The lethal dose varies from 10 to 30g of aspirin. However, there was 1 case of using a dose of 130g of aspirin but not dying.
What to do when you miss a dose:
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time. Note that double the prescribed dose should not be taken.

When using Decirid 81mg, you may experience unwanted effects (ADRs). Common, ADR >1/100:
Gastrointestinal: Nausea, vomiting, diarrhea and/or ulceration of the gastrointestinal tract, dyspepsia, heartburn, abdominal pain. Bleeding: Preoperative bleeding, epistaxis, hematoma, urogenital bleeding, tooth bleeding. Hematology: Leukopenia, thrombocytopenia, purpura, anemia. Anemia with corresponding clinical signs and symptoms such as weakness, pallor, and hypoperfusion is usually caused by bleeding (eg, undetected bleeding, acute or chronic bleeding) . Hemolysis and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency have been reported. Hypersensitivity and Skin Disorders: Urticaria, pruritus, skin rash, asthma, anaphylactic reactions, edema, nasal congestion and rhinitis. Uncommon, 1/1000 < ADR < 1/100:
Ear: Dizziness, tinnitus, dizziness, hearing loss. Rarely, 1/10,000 ≤ ADR < 1/1000:
Gastrointestinal: Gastrointestinal inflammation, vomiting blood, black stools. Bleeding: Gastrointestinal bleeding, cerebral hemorrhage. Several cases of potentially life-threatening bleeding have been reported, especially in patients with uncontrolled hypertension or concomitant antihypertensive medication. Very rare, ADR < 1/10,000:
Severe allergic reaction, anaphylaxis. Hepatic: Transient hepatic failure with elevation of hepatic transaminases. Renal: Renal failure, acute renal failure. When experiencing side effects of the drug, it is necessary to stop using it and notify the doctor or go to the nearest medical facility for timely treatment.

Before using the drug you need to carefully read the instructions for use and refer to the information below.
Contraindications
Decirid 81mg is contraindicated in the following cases:
Hypersensitivity to aspirin, salicylates, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, antipyretics or any of the ingredients. of the drug. Acute gastrointestinal ulcer. There is a history of gastrointestinal ulceration. The body is prone to bleeding. Liver failure, severe or progressive renal failure or congestive heart failure. History of asthma due to use of salicylates or substances with a similar mechanism of action, especially NSAIDs. On treatment with methotrexate at doses > 15 mg/week. During the last three months of pregnancy. Use cautions
General warnings
Aspirin is one of the most common causes of accidental poisoning in toddlers and infants. Therefore, the medicine should be kept out of the reach of children.
Caution should be exercised when administering aspirin to patients
Uncontrolled hypertension. Impaired hepatic, renal, or cardiovascular function (eg, acute vascular disease, congestive heart failure, extracellular volume depletion, major surgery, septic or major bleeding events). History of bleeding, significant anemia or hypoprothrombinemia. Are taking anticoagulants. Are taking low doses of ibuprofen. Hypersensitivity
Aspirin may cause bronchospasm and trigger asthma or other hypersensitivity reactions. Risk factors include bronchial asthma, seasonal allergic rhinitis, nasal polyps, or chronic respiratory disease. This undesirable effect may also occur in patients who have had allergic reactions (eg, skin reactions, pruritus, urticaria) to other substances.
Hematology
Because of its influence on platelet aggregation, aspirin may be associated with an increased risk of bleeding. Care should be taken when administering salicylates with anticoagulants simultaneously, as salicylates may decrease plasma prothrombin concentrations.
Before surgery
Because the drug's inhibitory effect on platelet aggregation persists for several days after oral administration, aspirin may increase the tendency to bleed during and after surgery (including minor surgeries, eg. like tooth extraction).
Special objects.
Women trying to get pregnant should not take aspirin during the first and second trimesters of pregnancy, unless absolutely necessary. If aspirin is given to a woman trying to get pregnant or during the first and second trimesters of pregnancy, it should be used at the lowest effective dose and for the shortest possible time. A possible association of Reye's syndrome with salicylates use in children has not been established. Reye's syndrome has also occurred in many patients not exposed to salicylates. Aspirin should not be used in children and adolescents to treat viral infections with or without fever without consulting a doctor. In some viral illnesses, especially influenza A, influenza B, and chickenpox, there is a risk of Reye's syndrome, which is rare but can be life-threatening and requires immediate medical attention. This risk is increased with concomitant use of aspirin, although a causal relationship has not been demonstrated. If you are vomiting constantly and have the above conditions, this could be a sign of Reye's syndrome. Reducing uric acid excretion at low doses, aspirin reduces the excretion of uric acid. This can cause gout in patients who tend to have low uric acid excretion. Glucose - 6 - phosphate dehydrogenase (G6PD) deficiency in patients with glucose - 6 - phosphate dehydrogenase (G6PD) deficiency, aspirin may cause hemolysis or hemolytic anemia. Factors that increase the risk of hemolysis are high doses of the drug, fever, or acute infection. Elderly people should be cautious when administering aspirin to the elderly (>60 years of age), as these subjects may be more sensitive to the adverse effects of the drug. Monitoring and laboratory testing of salicylates may alter the results of thyroid function tests. Cases of liver dysfunction (elevated transaminase enzymes) have been described. Excipients: Castor oil, Quinolein yellow lake color may cause allergic reactions. Ability to drive and use machines
There is no evidence of an effect on the ability to drive or use machines.
Pregnancy
Aspirin inhibits prostaglandin synthesis. Inhibition of prostaglandin synthesis may cause undesirable effects on pregnant women or the development of the embryo, fetus. Data from epidemiological studies raise concerns about an increased risk of miscarriage and malformation following the use of prostaglandin synthesis inhibitors during early pregnancy.
This risk is expected to increase with dose and duration of treatment. The available data do not suggest an association between taking aspirin and an increased risk of miscarriage. As for the available epidemiological data regarding aspirin's malformations, an increased risk of cleft palate cannot be ruled out. In a prospective study of drug exposure during early pregnancy (January to April) in approximately 14,800 mother-infant pairs, there was no association with increased odds. malformation rate.
During the third trimester of pregnancy, all prostaglandin synthesis inhibitors can expose the fetus to: cardiopulmonary toxicity (along with premature closure of the ductus arteriosus and pulmonary hypertension).
Renal dysfunction may progress to renal failure with low amniotic fluid. Use of any prostaglandin synthesis inhibitor in late pregnancy may expose the mother and child to:
May prolong bleeding time, possible antiplatelet effect even at very low doses. Inhibition of uterine contractions leads to delay or prolongation of labor. Therefore, aspirin use in the third trimester of pregnancy is contraindicated. Lactation
Aspirin and its metabolites are excreted in low concentrations in breast milk. Since no adverse effects have been observed in the neonate after infrequent use, it is not necessary to discontinue nursing. However, if used frequently or in high doses, breastfeeding should be discontinued early.

Caution should be exercised when using aspirin together with drugs with anticoagulant or antiplatelet effects, as these effects may be enhanced. Care should also be taken when administering drugs that are strongly protein bound because aspirin can displace these drugs for protein binding.
Contraindicated Interactions
Methotrexate at doses > 15 mg weekly: Increased hematologic toxicity of methotrexate (due to decreased renal clearance of methotrexate by anti-inflammatory drugs in general and by salicylates replacing methotrexate for binding to methotrexate). bound to plasma proteins).
Drug Interactions
Methotrexate at doses < 15 mg weekly: Salicylates may slow the elimination of methotrexate by reducing the renal clearance of methotrexate, displacing protein bound methotrexate, and thereby increasing the toxicity of methotrexate. methotrexate blood.
Anticoagulants, thrombolytics/other hemostatic platelet aggregation inhibitors, e.g. Warfarin, heparin: Caution should be taken when using salicylates with anticoagulants, thrombolytics, and binding inhibitors. platelet aggregation, as salicylates can reduce plasma prothrombin concentrations, leading to an increased risk of bleeding.
Oral hypoglycemic agents, e.g. insulin, sulfonylureas: High doses of salicylates have hypoglycemic effects and may enhance the effects of oral hypoglycemic agents. Patients with diabetes mellitus who receive salicylates with hypoglycaemic therapy should be closely monitored: A reduction in the dose of the sulfonylurea hypoglycemic agent may be necessary.
Diuretics: Use of diuretics in combination with high-dose aspirin leads to a decrease in glomerular filtration rate through a decrease in prostaglandin synthesis. As a result, sodium excretion may be reduced due to salicylates use.
Drugs that increase uric acid in urine: High doses of salicylates are drugs that increase uric acid in urine, at lower concentrations can reduce uric acid clearance and thereby reduce the uricosuric effect of other drugs.
Valproic acid: Salicylates may interfere with the metabolism of valproic acid (VPA) and may displace protein-bound VPA, possibly increasing the effect of VPA. Care should be taken when using VPA with salicylates. Systemic glucocorticoids, with the exception of hydrocortisone used as replacement therapy in Addison's disease: Decreases blood levels of salicylates during corticosteroid therapy and the risk of salicylate overdose after corticosteroid treatment is discontinued due to defection. Elimination of salicylates is enhanced by corticosteroids. Angiotensin-converting enzyme (ACE) Inhibitors: The hyponatremic and blood pressure-lowering effects of ACE inhibitors may be reduced by concomitant aspirin use due to the direct effect of aspirin on the renin-conversion pathway. - angiotensin (i.e. inhibition of vasodilatory prostaglandin leading to decreased glomerular filtration). The potential for an interaction may be related to the dose of aspirin (> 3 g/day).
Selective serotonin reuptake inhibitors (SSRIs): Increased risk of upper gastrointestinal bleeding due to synergistic effects.
Digoxin and lithium: Aspirin reduces the renal elimination of digoxin and lithium, leading to an increase in their plasma concentrations. Plasma concentrations of digoxin and lithium should be monitored during initiation and termination of aspirin therapy. Adjust dose if necessary.
Carbonic anhydrase enzyme inhibitors (acetazolamide): May cause severe acidosis and increased CNS toxicity.
Ciclosporin, tacrolimus: Concomitant use of NSAIDs and ciclosporin or tacrolimus may increase the nephrotoxic effects of ciclosporin and tacrolimus. Renal function should be monitored when these drugs are used together with aspirin.
Aspirin and other NSAIDs: The use of NSAIDs with high doses of salicylates (> 3g/day) may increase the risk of gastrointestinal ulceration and bleeding due to synergistic effects.
Ibuprofen : Ibuprofen may interfere with the antiplatelet effect of low-dose aspirin (81 - 325 mg daily). Long-term use of ibuprofen may reduce the effectiveness of aspirin in preventing heart disease and stroke. To minimize this interaction, patients who regularly take ibuprofen concomitantly with low-dose rapid-release aspirin should take ibuprofen at least 1 hour after and 11 hours before aspirin. Delayed-release aspirin should not be used when regular ibuprofen is used. Physicians should advise patients about the use of ibuprofen with aspirin.
Phenytoin (antiepileptic drug): Salicylates reduce the binding of phenytoin to plasma albumin. This may lead to a decrease in the total plasma concentration of phenytoin, but an increase in the concentration of free phenytoin. Free drug concentrations and therapeutic efficacy do not appear to be significantly altered.
Alcohol: Concomitant use with alcohol and acetylsalicylic acid increases the risk of gastrointestinal bleeding. Antacids will reduce the effect of aspirin. The principle of incompatibility is iron salts, carbonates and alkali hydroxides.
Interactions with laboratory tests: Salicylates may alter the results of tests that evaluate thyroid function.
Drug incompatibilities
Since there are no drug incompatibility studies, do not mix this drug with other drugs.
Storage:
Store the medicine in a dry, ventilated place, the temperature is below 30°C, protected from light.