Uses of Drotacolic

Drotacolic drug with the main active ingredient is Drotaverin hydrochloride 40mg, often used by doctors to fight contractions in smooth muscles of the stomach - intestines, uterus, urinary - genital tract,... Articles The following will provide useful information to help you use Drotacolic safely and effectively.

Drotaverin is an active substance belonging to the antispasmodic subclass of smooth muscle without anticholinergic properties, its chemical structure is similar to the active substance papaverin. Through its selective inhibitory effect on the enzyme phosphodiesterase 4 (PDE 4), Drotaverin increases cyclic AMP levels and decreases intracellular calcium ion concentrations, which leads to a decrease in the contractility of smooth muscles. However, the special thing is that Drotaverin only works to reduce the spasm of smooth muscles mainly in the digestive system and the urinary-genital system, it completely does not affect the smooth muscles in the circulatory system such as: vascular smooth muscle or cardiac muscle. This is because the enzyme that hydrolyzes cyclic AMP in vascular smooth muscle is the PDE 3 isoenzyme, whereas drotaverin acts only selectively on PDE 4, which explains why Drotaverin is used as an effective antispasmodic agent. results but at the same time does not cause unwanted effects on the heart.
With the above mechanism of action, Drotacolic is often prescribed by doctors in the following cases:
Patients with irritable bowel syndrome or experiencing pain caused by spasms of the stomach - intestines; Patients with pain diagnosed caused by biliary spasm in cholecystitis, gallstones, ...; Cases of urinary - genital spasms; The patient suffered from dysmenorrhea and threatened miscarriage due to uterine contractions. In addition, because Drotacolic is a class of drugs with no anticholinergic effect, it is an appropriate choice for patients with underlying medical conditions such as glaucoma or prostate enlargement - these are patients contraindicated to the drug. anticholinergic smooth muscle relaxants.

Drotacolic can be used for both adults and children over 12 months old with the following dosage:
Adults: Take 1-2 tablets/time, use 3 times/day; Children over 6 years old: Take 1 tablet/time, use 2-3 times/day; Children from over 12 months old - 6 years old: Take 1⁄2 - 1 tablet/time, use 2-3 times/day. The drug is recommended to be used after meals and should be stored in a dry place, away from direct light to ensure the quality of the drug is not affected.

Drotacolic is contraindicated in the following cases:
Patients with hypersensitivity to the components of the drug; Patients diagnosed with severe liver, kidney or heart failure; Drotacolic should not be used in pediatric patients under 12 months of age because there are insufficient data on safety and efficacy in this population. For patients being treated with Levodopa , before using Drotacolic should consult a doctor because Drotacolic has been shown to reduce the activity of Levodopa.
If the patient has lactose intolerance, the drug Drotacolic should be used with extreme caution, because the excipients of Drotacolic contain most of the lactose.
In the case of pregnant or lactating patients, although there is no evidence that Drotacolic has an adverse effect on the fetus, the use of the drug in these cases should be limited and should be consulted. Doctor's supervision and consultation to ensure the highest safety.
If your job involves driving a vehicle or operating machinery, caution should be exercised when using Drotacolic as the side effects of the drug may affect the quality of work.
Although there have not been any reports of an overdose of Drotacolic, but if you use too much of the recommended dose and have unusual symptoms, you should immediately contact your doctor or go to a medical center for treatment. timely mind.

When using Drotacolic, patients may experience some unwanted symptoms as follows:
On the digestive system: The most common symptoms are nausea, vomiting or constipation. On the nervous system: Using Drotacolic causes headaches, dizziness, even insomnia. Cardiovascular system: Patients may experience palpitations or hypotension. On the immune system: Some patients may have allergic reactions such as hives, rash,... However, studies have shown that unwanted symptoms when using Drotacolic are often rarely. If the patient has the above signs, should contact and notify the doctor to make appropriate adjustments in the use of the drug.