Uses of Duraject 60

Duraject 60 is manufactured by Akums Drugs & Pharmaceuticals Ltd. - INDIA. Duraject 60 is classified as a psychotropic drug whose main active ingredient is Dapoxetin (as Dapoxetin HCl).
Dosage form: film-coated tablets, each containing 60mg Dapoxetin and other excipients. Packing form: blister of 4 tablets, each box has 1 blister.

Dapoxetine is a selective serotonin inhibitor. The phenomenon of ejaculation in humans is mainly mediated by the sympathetic nervous system. The process begins at a reflex center in the spinal cord, mediated through the brain stem, and is affected by a number of nuclei in the brain. The effects of dapoxetine in premature ejaculation involve inhibition and reuptake of serotonin.
In laboratory mice, dapoxetine inhibits the ejaculatory reflex through a mechanism of action above the spine in the paraventricular nucleus, resulting in anterior sympathetic ganglia, vas deferens, prostate gland, and urinary diaphragm. , the bladder neck contracts to achieve ejaculation.

Duraject 60 is used in the treatment of premature ejaculation in men aged 18 to 64 years who meet all of the following criteria:
Vaginal ejaculation wait time less than 2 minutes Feeling of discomfort, anxiety Poor ejaculation control History of premature ejaculation in the last 6 months Persistent/recurring ejaculation with prior sexual stimulation before the patient's intention. Contraindications: Absolutely do not use Duraject 60 in the following cases:
Patients with hypersensitivity to any ingredient of Duraject 60 Under 18 years old Patients with moderate to severe liver failure, severe renal impairment Severe chronic cardiovascular disease History of major depression, mania Are taking strong inhibitors of CYP3A4 such as itraconazole, ketoconazole,.. Concomitant use with monoamine oxidase inhibitors or within 2 weeks of discontinuation of the drug monoamine oxidase inhibitors. Do not use monoamine oxidase inhibitors within 7 days after stopping taking Duraject 60. Take with thioridazine or within 14 days after stopping taking thioridazine. Do not use thioridazine within 7 days after stopping Duraject 60. Take it with serotonin reuptake inhibitors, tricyclic antidepressants, herbs with sympathomimetic effects or within 2 weeks after stopping the drugs. medicine above. Do not use these medicines within 7 days of stopping Duraject 60.

In order for Duraject 60 to be effective and safe to use, you need to follow your doctor's instructions on dosage, route of administration, and duration of treatment. Do not arbitrarily change the dose, route of administration or give medicine to others even if they have the same medical condition as you.
Dosage: 30mg/time, taken 1-3 hours before sexual activity. Do not initiate Duraject 60 at a dose of 60 mg.
Attention:
Do not use Duraject 60 continuously every day, only use when intending to have sex. Do not use more often than 1 time spaced less than 24 hours. If the patient does not respond well to the 30mg dose and there are no unwanted effects, the dose can be increased to 60mg and taken 1-3 hours before sexual activity. With a dose of 60 mg, the incidence and severity of adverse events was higher. The risks and benefits of Duraject 60 should be assessed after the first 4 weeks of use to determine if it should be continued. Directions: Swallow the tablet whole with a full glass of water to avoid a bitter taste. Duraject 60 can be taken with or without food.
What to do in case of an overdose of Duraject 60?
When overdose, may appear symptoms such as nausea, vomiting, tachycardia, agitation, dizziness, tremor, .. Take the patient immediately to the nearest emergency center for treatment, It is necessary to bring all medications used by the patient to facilitate the diagnosis. There is no specific antidote for Duraject 60. Treatment includes supportive treatment.

During the use of Duraject 60, you may encounter unwanted effects such as:
Common: insomnia, anxiety, agitation, restlessness, decreased libido, tremor, paresthesia, blurred vision , sinusitis, nasal congestion, digestive disorders, increased sweating, erectile dysfunction, increased blood pressure, fatigue, irritability,... Uncommon: depression, mania, mood swings, worship agitation, apathy, confusion, abnormal thoughts, sleep disturbances, nightmares, syncope, postural dizziness, mydriasis, visual disturbances, tachycardia, hypotension, hypertension, pain epigastric abdomen, cold sweat, weakness, ... Rare: dizziness on exertion, sudden drowsiness, bowel incontinence, ... The adverse effects mentioned above are incomplete, You may experience other side effects that have not been listed or studied while taking Duraject 60. So to be on the safe side, tell your doctor as soon as any of these symptoms appear. usually.

Drugs that may interact with Durajec 60 include:
CYP3A4 inhibitors such as: ketoconazole, itraconazole, ritonavir, saquinavir, telithromycin, nefazodone, nelfinavir and atazanavir, erythromycin, clarithromycin, fluconazole, amprenavir, fosamprenavir, aprepitant, verapamil, diltiazem. Strong CYP2D6 inhibitors. Tamsulosin . PDE5 Inhibitors

Keep Duraject 60 in a cool, dry place, away from direct light, at a temperature not exceeding 30 degrees Celsius. Keep Duraject 60 out of reach of children and pets. Before using, it is necessary to check the expiry date stated on the package, do not use the medicine that has expired on the package or has signs of color or nature change.
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