Uses of glutipha 850

Gludipha 850 is formulated in the form of film-coated tablets with the active ingredient Metformin hydrochloride indicated in the treatment of patients with non-insulin dependent diabetes mellitus (Type II).

The active ingredient metformin is rapidly and easily absorbed from the gastrointestinal tract and selectively concentrated in the intestinal mucosa. The drug is excreted unchanged in the urine. The half-life of metformin is approximately 4 hours and clinical efficacy is maintained for up to 8 hours. The maximum effect time is about 2 hours after taking.

Metformin has the effect of lowering blood sugar to a stable level in diabetic patients with hyperglycemia. The drug has the advantage of not having a noticeable hypoglycemic effect in people without diabetes. To date, the specific mode of action of metformin has not been elucidated. There are several explanations for the mode of action such as:
Metformin inhibits intestinal glucose absorption. Promotes glucose utilization in cells. Inhibits gluconeogenesis in the liver. Therefore, Gludipha 850mg is indicated for use in the following cases:
Type II diabetes (Non-insulin dependent): when it is not possible to treat hyperglycemia with diet alone, it can be used in monotherapy. When patients on sulfonylureas do not provide adequate glycemic control, concomitant use of metformin may be considered.

Patients with non-insulin-dependent diabetes mellitus can use an initial dose of 500 mg/day after meals to minimize gastrointestinal adverse effects. In case blood sugar is not controlled, the dose can be gradually increased to a maximum of 5 tablets of 500mg or 3 tablets of 850mg/day, taken 2 to 3 times.

The drug is contraindicated for use in patients with a history of hypersensitivity to drug components, diabetic pre-coma, ketoacidosis, severe infection, renal failure, cases causing tissue hypoxia such as recent infarction. myocardial infarction, heart failure, respiratory failure, shock, liver failure, alcoholism, acute alcohol intoxication, elective major surgery, pregnant or lactating women,.
Care should be taken to combine glutipha 850mg with drugs such as Glucocorticoids, ACEIs, beta 2 blockers, diuretics.

In the process of using the drug may cause some undesirable effects such as:
Increased lactic acid causes nausea, metallic taste in the mouth, acidemia. About 10 to 15% of patients have gastrointestinal disorders with symptoms such as abdominal pain, nausea, and diarrhea occurring in the stomach. This condition can be significantly reduced if metformin is taken after meals and with gradual dose increases. Vitamin B12 deficiency has also been reported but with very rare incidence due to long-term use due to the effect of the drug on the absorption of vitamin B12 in the small intestine. Gludipha 850 is a medicine containing the main ingredient is Metformin hydrochloride. The drug is indicated in the treatment of patients with type II diabetes. To ensure effective treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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