Uses of H vacolaren

The drug H-Vacolaren 20mg has the main ingredient Trimetazidin.2HCl. The drug is indicated as an adjunct to or as an adjunct to therapy. It is useful in the symptomatic treatment of patients with stable angina that is inadequately controlled or intolerant to other therapies.

H Vacolaren 20mg is made in the form of film-coated tablets. Medicine box contains 02 blisters x 30 tablets. Each tablet contains 20 mg of trimetazidin.2HCl.
H Vacolaren 20mg is indicated for adults in adjunctive or adjuvant therapy. It is effective in the symptomatic treatment of patients with inadequately controlled stable angina or who are intolerant to other therapies for angina.

Mechanism of action: H vacolaren 20mg inhibits the beta oxidation of fatty acids in ischemic cells. The energy obtained in glucose oxidation requires less oxygen consumption than in beta oxidation. The promotion of glucose oxidation will help optimize cellular energy processes, thereby maintaining proper energy metabolism during periods of anemia. Pharmacodynamic effects: In patients with ischemic heart disease, the active ingredient trimetazidine acts as a metabolite, helping to preserve high intracellular phosphate energy levels for cardiomyocytes. Active ingredient Trimetazidine is effective in the prevention of ischemia but does not affect hemodynamics.

Trimetazidine when taken orally is very rapidly absorbed and reaches peak plasma concentrations 2 hours after dosing. The maximum concentration of H Vacolaren 20 mg in plasma, after a single dose of Trimetazidine 20 mg, is about 55 mg/ml. Drug equilibrium in the blood is reached between 24 and 36 hours after a single dose repeat and is very stable during treatment. The mean half-life of trimetazidine is 6 hours. H vacolaren 20mg drug is excreted mainly in the urine as unchanged drug.

Coronary insufficiency (prevention of angina, used after acute myocardial infarction); Treatment of eye diseases such as damage to blood vessels in the retina; Treatment of ear disease such as Meniere's vertigo or due to vasomotor causes, hearing loss. 3. How to use and dose H Vacolaren How to use H Vacolaren 20mg:
Use H Vacolaren 20mg orally, during meals; Swallow the tablet whole, do not chew, break or break the drug structure. Dosage of H Vacolaren 20mg:
Take 1 tablet/time x 3 times/day, take with meals; People with moderate renal failure (creatinine clearance [30 - 60] ml/min) and elderly people: Take 1 tablet/time x 2 times/day, morning and evening, with meals; Care should be taken when calculating the therapeutic dose for the elderly because of a higher than normal level of trimetazidine sensitivity due to age-related decline in renal function; In children, safety and efficacy have not been evaluated. There are no data in children. How to deal with missed dose or overdose:
When you miss a dose of H Vacolaren 20mg, you should take it again as soon as possible. However, you should be careful to skip the missed dose if it is too close to your next dose. At the same time, you still take your next dose as usual. Absolutely do not use H Vacolaren 20mg twice the dose to make up for the forgotten part; When overdosing on H Vacolaren 20mg: Currently, no case of overdose has been recorded. However, if you notice any unusual symptoms, see your doctor immediately or go to the nearest medical facility for timely examination and treatment. 4. Undesirable effects of the drug H Vacolaren During the use of the drug, you may experience the following undesirable effects:
Common adverse effects:
Dizziness, headache; Asthenia ; Digestive disorders: Diarrhea, abdominal pain, nausea, vomiting, dyspepsia; Itching, hives on the skin; Rare adverse effects:
Palpitations, tachycardia accompanied by palpitations, extrasystoles; Postural hypotension, arterial hypotension causing dizziness, falling, discomfort,... Some other adverse effects may be encountered such as:
Parkinson's disease symptoms such as tremor, difficulty in movement, increased muscle tone; Unsteady gait, restless legs syndrome or other related movement disorders; Psychiatric and sleep disorders: prolonged insomnia; Appearance of rash, acute generalized pustules, angioedema; Agranulocytosis, thrombocytopenia, hemorrhagic rash; Hepatitis. Immediately notify the treating doctor when seeing any side effects for advice and reasonable treatment.
5. Interactions of H Vacolaren Currently, there are no clinical reports on possible interactions when combining H Vacolaren 20mg with other pharmaceuticals. However, to ensure the safety and effectiveness of treatment, please list with your treating doctor or clinical pharmacist the drugs, including functional foods you are using, to be considered for dose adjustment. reasonable use.
6. Some notes when using H Vacolaren Before using H Vacolaren 20mg you need to carefully read the instructions for use and refer to the information below.
Contraindications of H Vacolaren 20mg:
Hypersensitivity to the active ingredients or any of the excipients listed in the product formulation; People with Parkinson's disease, Parkinson's symptoms, tremors, restless legs syndrome and other related movement disorders; Severe renal impairment with creatinine clearance greater than 30 ml/min. Precautions while using H Vacolaren 20mg:
Active ingredient trimetazidin may cause or worsen Parkinson's symptoms including tremor, slow and difficult movement, increased muscle tone. Therefore, drug users, especially elderly patients, should be checked and monitored regularly. In doubtful cases, the user should be referred to neurologists for appropriate examination; When experiencing movement disorders such as Parkinson's symptoms, restless legs syndrome, tremor, unsteady gait, it is necessary to immediately stop using H Vacolaren 20mg; These cases are rare and usually reversible after discontinuation of H Vacolaren 20mg. Most users recover about 4 months after stopping the drug. If symptoms of Parkinson's disease persist for 4 months or more after drug discontinuation, a neurologist should be consulted; Falling, unsteady gait or hypotension may occur, especially in people taking antihypertensive drugs; Use with caution in people with moderate renal impairment and over 75 years of age. Storage of H Vacolaren 20mg:
Store the drug in a cool, dry place, away from light; The temperature does not exceed 30°C; Keep out of reach of small children. Effects on other populations:
Ability to drive and use machines: H Vacolaren 20mg may cause symptoms such as dizziness and drowsiness, which in turn may affect the ability to drive or use machines. operating machinery; For pregnant and lactating women: There are not enough data to prove the safety and risks when using H Vacolaren 20mg for pregnant and lactating women. Therefore, you should only use the drug when prescribed by a specialist doctor; For drivers and operators: H Vacolaren 20mg may cause unwanted effects including dizziness, drowsiness, affecting the ability to drive and use machines. Therefore, you need to be careful when using these objects.