Uses of Kegynan

Kegynan drug contains 3 main ingredients: Metronidazole, Neomycin sulfate, Nystatin. This is a vaginal suppository commonly used to treat symptoms of vaginitis, caused by certain types of fungi or bacteria.

Drug name: Kegynan; Dosage form: Tablets placed in the vagina; Group: Gynecological drugs; The following are the main ingredients in Kegynan:
Metronidazol (500mg): has antibacterial effects, especially against gram-negative anaerobes. This active substance is usually eliminated in the urine, very rarely in the feces. Neomycin sulfate (65,000 UI): has a good effect in the treatment of bacterial infections. This active substance is less likely to bind to plasma proteins and is diffused mainly into the extracellular fluid. Neomycin is eliminated mainly by the kidneys. Nystatin (100,000 UI): is an antifungal antibiotic that can be used for a long time without resistance. This active substance is usually eliminated mainly in the faeces as unchanged drug. In addition, in the composition of the drug Kegynan also contains other excipients in just enough 1 tablet.

Kegynan drug is usually indicated to overcome the symptoms of vaginal itching, abnormal discharge, unpleasant odor in the following cases:
Vaginitis caused by fungal infection, bacterial infection; Candida vaginitis ; Vaginitis caused by S.aureu, Trichomonas, E.coli bacteria...

You need to talk directly with your doctor to understand how to use, dosage and how often to use Kegynan. Absolutely do not change the method of use as well as the dose without the doctor's instructions.
3.1. About how to use Kegynan Wash your hands and private parts clean and dry before putting Kegynan You should lie on your back with knees bent; Dip the whole Kegynan tablet for 2-3 seconds in warm water; Clamp the Kegynan pill between 2 fingers and then push it as deep into the vagina as possible (need to trim nails so as not to cause vaginal damage); Wash your hands with soap after applying Kegynan; Lie down and rest after placing the medicine for at least 15-20 minutes. 3.2. About the dosage of Kegynan Use Kegynan 1 tablet/time, 1-2 times/day; The treatment dose can be adjusted up to 2 - 3 tablets, 2 times a day. Order medicine continuously within 7-10 days; Do not use for more than 14 days, even in severe illness. Dosage depends on the condition and condition of the patient. There is no need to adjust the dose for patients with liver or kidney failure. When used in the elderly, it is necessary to start with a low dose and then increase it gradually. Safety and effectiveness in the treatment of young children have not been established. 3.3.In case of missed dose, overdose In case of missed dose: take Kegynan to make up for it as soon as you remember. However, if it is close to your next dose within 6 hours, skip the previous dose and continue as scheduled. Do not take a double dose of Kegynan to make up for a missed dose. In case of overdose: Symptoms: If the drug overdose can lead to hypotension, fainting, tachycardia, headache, dizziness, blurred vision, lethargy, flushing, vomiting, diarrhea,. .. High therapeutic doses can make the patient cyanosis, shortness of breath, convulsions. Very high therapeutic doses can lead to increased intracranial pressure. Overdose of Kegynan over a long period of time can increase Methaemoglobin levels. Treatment: The doctor will perform gastric lavage when the overdose is new. Give fluids in case of hypotension or shock. In case of methaemoglobinemia should use: Vitamin C 1g orally or intravenously; Methylene blue intravenously; Toluidine blue intravenous injection; oxygen, hemodialysis, blood exchange.

At the beginning of using Kegynan, you are very likely to experience unwanted effects such as burning, or irritation of the vagina. However, it is not necessary to stop using the drug when these signs are mild and not too obvious. The adverse effects reported during use are as follows:
Headache; Low blood pressure, increased heart rate, dizziness, slow heart rate, nervousness or fainting; Nausea, dry mouth, loss of taste; flushing, blurred vision; Allergic reactions, red rash on the surface of the skin; Ankle edema; Methaemoglobin in the blood. Pay attention to monitor during treatment with Kegynan and report to the treating doctor when abnormal manifestations arise. The treating doctor may adjust the dose or stop the drug when absolutely necessary. Absolutely do not arbitrarily overcome the unwanted effects in any way. Immediately notify the treating doctor of any unwanted effects encountered during the use of Kegynan.

Proven drug interactions are as follows:
Vasodilators, antihypertensives, β-blockers, calcium channel blockers, diuretics, sedatives, tricyclic antidepressants: Increases Nitroglycerin effect. Dihydroergotamine: When used in combination with the drug Kegynan increases blood levels of Dihydroergotamine, leading to hypertension and ischemia. Heparin: Reduces anticoagulant effect of the drug Heparin. Sildenafil, Tadalafil: Combined antihypertensive effect, possibly life-threatening resulting in death. Laxatives: Reduces absorption and reduces the concentration of nitroglycerin in the blood. Inform the treating doctor about the drugs you are using for guidance on safe and effective use of the drug.

6.1. Contraindications of the drug Kegynan Not to be used for:
People with a history of hypersensitivity to active ingredients Nitroglycerin or other organic nitrate compounds; Low blood pressure; Acute circulatory failure; Cardiac shock; Acute myocardial infarction ; Myocardial hypertrophy, obstruction; Decreased blood volume; Mitral stenosis; Pericarditis or pericardial compression; Circulatory disturbances when standing; Increased intracranial pressure or intracranial hemorrhage; Severe anemia; Concomitant use with Phosphodiesterase inhibitors; Use for pregnant women and nursing mothers. 6.2. Other precautions when using Kegynan Stopping treatment with Kegynan suddenly can cause angina attacks, the dose should be gradually reduced until completely stopped. Kegynan should not be used to treat acute angina. The use of Kegynan drug starts with a low dose and gradually increases the dose when used in the elderly because of the risk of orthostatic hypotension in this group of subjects. In order to avoid myocardial hypovolemia and myocardial ischemia, treating physicians usually use caution in patients with cardiac pulmonary disease or arterial hypoxemia. Use with caution in people with severe liver or kidney disease, mitral valve prolapse, low body temperature, recent myocardial infarction, hypothyroidism. Do not use Kegynan alcoholic beverages during treatment. Because the composition of the drug contains Lactose, it should not be used for those who lack the enzyme Lactase, Galactose - blood and glucose - Galactose malabsorption. 6.3. Recommendations when using Kegynan Kegynan medicine contains only a small amount of the active ingredient Neomycin. Because in this ingredient can cause neuromuscular blockade. Therefore, extreme caution should be exercised when using Kegynan in people with myasthenia gravis. Some mechanical contraceptives may have reduced reliability when used together with Kegynan. To avoid unwanted pregnancy should avoid sexual intercourse while using the drug. At the same time, combine treatment for both sexual partners to avoid re-infection. In short, the use of Kegynan drug needs to follow the instructions and consult the doctor. Using the right medication at the right dose and purpose will bring good results to the patient.