Uses of Klamentin 500/125

Klamentin 500/125 is a drug used in the treatment of bacterial infections. The following article will introduce the use and use of this drug.

Klamentin 500/125 is a medicine with the main ingredient of a mixture of 500mg Amoxicillin and 125mg Clavulanic Acid. Klamentin is indicated for use in both adults and children for the treatment of the following infections:
Acute sinusitis Acute otitis media. Acute exacerbation of chronic bronchitis. Community-acquired pneumonia Cystitis Pyelonephritis Skin and soft tissue infections, especially insect bites, cellulitis, alveolar abscess. Musculoskeletal infections, especially osteomyelitis.

Dosages used are calculated according to the composition of Amoxicillin/clavulanic acid, except when individual doses are stated. Dosage depends on various factors such as the pathogen, susceptibility to antibacterial agents, site and severity of infection, weight, age, and renal function of the patient.
For adults and children weighing over 40 kg: Take a total daily dose of 1500 mg amoxicillin/375 mg clavulanic acid (as recommended below). Dosage for each time is 500 mg / 125 mg x 3 times / day. For children weighing less than 40 kg: The maximum recommended daily dose is 2400 mg amoxicillin/600 mg clavulanic acid. In cases where a higher daily dose of amoxicillin is required, another preparation of Klamentin should be chosen to limit the use of unnecessarily high doses of clavulanic acid. This age group can use doses ranging from 20 mg / 5 mg / kg / day to 60 mg / 15 mg / kg / day, divided into 3 times. The duration of drug use is determined according to the degree of response of the patient. Some cases require longer treatment time such as bacterial infections in osteomyelitis. The duration of treatment should not exceed 14 days.

The use of Klamentin is contraindicated in patients with a history of hypersensitivity to beta-lactam antibiotics such as penicillins, cephalosporins or any of the ingredients. In addition, patients with a history of jaundice or liver dysfunction related to amoxicillin/clavulanic acid should also consult their physician before using this medicine.

Oral anticoagulants: Oral anticoagulants and penicillin antibiotics are widely used and rarely reported interactions. However, there have been some reports of increased INR in patients taking warfarin or acenocoumarol and taking a course of amoxicillin. If necessary, carefully monitor prothrombin, INR or consider discontinuing amoxicillin.
Methotrexate: Co-administration with Klamentin has the potential to increase the hematological toxicity of methotrexate due to inhibition of renal tubular secretion by penicillin antibiotics.
Probenecid: Reduces the excretion of amoxicillin in the renal tubules, causing an increase in amoxicillin concentration in the blood.

The most common adverse effects are nausea, vomiting and diarrhea.
Therefore, before initiating treatment with amoxicillin/clavulanic acid, the patient should be thoroughly questioned about hypersensitivity reactions to penicillins, cephalosporins or other allergens.
In the case of patients with infections proven to be caused by amoxicillin-susceptible organisms, it is advisable to switch from amoxicillin/clavulanic acid to amoxicillin.
Avoid use of amoxicillin/clavulanic acid in cases of suspected infectious mononucleosis due to the presence of a measles-associated rash.
Allergic skin reactions may occur when allopurinol is used concurrently during treatment with amoxicillin.
Prolonged treatment with Klamentin may cause superinfection by overgrowth of non-susceptible organisms.
The above is important information about Klamentin, but it is not a substitute for your doctor's advice. Therefore, patients should carefully read the instructions and strictly follow the instructions of a qualified person when using the drug.

Reference source: thuocbietduoc.com