Uses of Lamestad 100

Lammostad 100 has the main ingredient Lamotrigine, the content of 100g, is prepared in the form of tablets. Mechanism of action of Lamestad 100 in experimental and clinical studies shows that there are 2 types of action: Direct effects related to valproate concentrations in plasma and in the brain. Acts indirectly by acting on neurotransmitter mediators or acting directly on cell membranes via metabolites.

Lammostad 100 is used for the combined treatment of epilepsy in adults and children, for the treatment of bipolar disorder.
Treatment of epilepsy:
In adults and in children over 12 years of age: The drug is used as monotherapy or as an adjunct in the treatment of partial and general seizures, including tonic-clonic seizures. Seizures are associated with Lennox-Gastaut syndrome. In children 2-12 years of age: It is used as adjunctive treatment for partial and generalized seizures, including tonic-clonic seizures and epilepsy associated with Lennox-Gastaut syndrome. Monotherapy for partial absence seizures. Treatment of Bipolar Disorder
In adults 18 years of age and older: The drug is effective in preventing depressive episodes in patients with bipolar I disorder, mainly with depressive episodes.

Do not use Lamestad if you have a hypersensitivity to Lamotrigine or any of its ingredients or to valproate sodium. Lammostad is not used in cases of diseases: Acute hepatitis, Chronic hepatitis, family history of severe hepatitis, especially drug-induced hepatitis, Porphyria.

Lammostad 100 is used according to the doctor's prescription, depending on the patient's clinical response, you can refer to the dosage below:
Treatment of epilepsy
Treatment of monotherapy: For adults and children over 12 years: Start with 25mg once daily for the first 2 weeks. This was followed by a dose of 50 mg once daily for the next 2 weeks. Then increase the dose to a maximum of 50-100 mg every 1 to 2 weeks until a response is achieved. Maintenance dose: 100-200 mg/day, divided 1-2 times/day.
Supportive treatment: In adults and children over 12 years of age:
In patients taking valproate with or without other antiepileptic drugs: In the first 2 weeks, Start with 25 mg every other day; In the next 2 weeks, the dose is 25 mg, once a day; The dose should then be increased to a maximum of 25-50 mg every 1 to 2 weeks until a response is achieved; Maintenance dose: 100-200 mg/day, divided 1-2 times/day. In patients who are taking other antiepileptic drugs or other drugs that induce lamotrigine glucuronide with or without other antiepileptic drugs except valproate: In the first 2 weeks start at a dose of 50 mg once daily; For the next 2 weeks 100 mg/2 times/day; Then increase the dose, to a maximum of 100 mg every 1-2 weeks; Maintenance dose: 200-400 mg/2 times/day. In subjects receiving oxcarbazepine not receiving any other lamotrigine glucuronide inhibitor or inducer: For the first 2 weeks, initial dose: 25 mg once daily; The next 2 weeks use a dose of 50 mg, 1 time / day; Then increase the dose, to a maximum of 50-100 mg every 1-2 weeks; Maintenance dose: 100-200 mg/day, divided 1-2 times/day. In children 2-12 years old:
In children taking valproate with or without other antiepileptic drugs: the first 2 weeks, start with 0.15 mg/kg once a day; the next 2 weeks 0.3 mg/kg, 1 time/day; Then increase the dose, to a maximum of 0.3 mg/kg every 1-2 weeks; Maintenance dose: 1-5 mg/kg, divided 1-2 times/day. In children receiving other antiepileptic drugs or other drugs that induce lamotrigine glucuronide with or without other antiepileptic drugs except valproate: For the first 2 weeks, the initial dose is 0.6 mg/kg in 2 divided doses. times/day; The next 2 weeks 1.2 mg/kg, divided into 2 times/day; Then increase the dose, to a maximum of 1.2 mg/kg every 1-2 weeks; Maintenance dose: 5-15 mg/kg, divided into 2 times/day. In children receiving oxcarbazepine, without any other inhibitors or inducers of lamotrigine glucuronide: first 2 weeks starting at 0.3 mg/kg in divided doses 1-2 times daily; In the next 2 weeks 0.6 mg/kg, divided 1-2 times/day; Then increase the dose, to a maximum of 0.6 mg/kg every 1-2 weeks; Maintenance dose: 1 - 10 mg/kg, divided 1-2 times/day, up to a maximum of 200 mg/day. Treatment of Bipolar Disorder
Lamotrigine monotherapy or adjunctive therapy without valproate and inducers of lamotrigine glucuronide: During the first 2 weeks, start at 25 mg once daily; In the next 2 weeks 50 mg, divided 1-2 times/day; Week 5 increase dose to 100 mg, divided 1-2 times/day; During week 6, the stable dose is 200 mg, divided 1-2 times/day. Combination therapy with valproate: first 2 weeks, starting dose 25 mg, administered every other day; the next 2 weeks 25 mg, 1 time / day; Week 5, dose 50 mg, divided 1-2 times/day; Week 6, stable dose is 100 mg, divided 1-2 times/day; The maximum dose may be 200 mg/day depending on response. Adjuvant therapy without valproate and with drugs that induce lamotrigine glucuronide: first 2 weeks, starting dose of 50 mg once daily; Next 2 weeks 100 mg, divided into 2 times/day; Week 5, 200 mg dose, divided into 2 times/day; Week 6, the stable dose is 300 mg, divided into 2 times/day, the dose can be changed depending on the response; Week 7, the optimal response dose is 400 mg/day, divided into 2 times/day. Dose adjustment of Lamosad when starting additional lamotrigine glucuronide inducers:
With the target dose used 200 mg/day: Week 1, dose 200 mg/day; Week 2, dose 300 mg/day; From week 3 onwards, the dose is 400 mg/day. With the target dose used 150 mg/day: Week 1, dose 150 mg/day, Week 2, dose 225 mg/day; From week 3 onwards, the dose is 300 mg/day. With a target dose of 100 mg/day: Week 1, dose of 100 mg/day; Week 2 dose 150 mg/day; From week 3 onwards, the dose is 200 mg/day. Dosage adjustment of Lamosad when starting to discontinue lamotrigine glucuronide inducers:
With target dose used 400 mg/day: Week 1, dose 400 mg/day, Week 2, dose 300 mg/day; From week 3 onwards, the dose is 200 mg/day (may be up to 400 mg). With the target dose used 300 mg/day: Week 1, dose 300 mg/day, Week 2, dose 225 mg/day; From week 3 onwards, the dose is 150 mg/day (may be up to 400 mg). With the target dose used 200 mg/day: Week 1, dose 200 mg/day, Week 2, dose 150 mg/day; From week 3 onwards, the dose is 100 mg/day (may be up to 400 mg). In patients with moderate to severe hepatic impairment: reduce the dose of Lamestad by 50-75%.
In patients with end-stage renal failure: reduce the maintenance dose of Lamestad.
How to use Lamestad 100: Lammostad drug is made in the form of tablets, taken orally. Patients need to drink the tablet whole with water, do not break the medicine, do not chew the medicine.

Lammostad drug precautions 100
Sudden unexplained death in seizures, 20 out of 4,700 cases reported in adjuvant therapy of sudden unexplained death. This evidence cannot be substantiated, possibly due to the subject of treatment rather than to the drug. Status Epilepsy: There have been some reports of an increase in seizures of a different nature Suicidal behavior: There have been reports of suicidal ideation and behavior in patients treated with antipsychotics. epilepsy when used for multiple indications. Therefore, the patient's behavior should be monitored, the doctor should advise the patient and the patient's family to come up with the most appropriate treatment regimen. Skin rash: There have been reports of skin side effects with Lamotrigine in the first few weeks, mostly mild rash, rarely severe rash requiring hospitalization and discontinuation of the drug. Use caution when treating people with a history of allergy or rash to other antiepileptic drugs. Lamotrigine should be identified and discontinued immediately in all patients with a rash, unless the rash is unrelated to the drug. Lamotrigine should not be re-administered in individuals with prior hypersensitivity. The use of hormonal contraceptives will increase the clearance of Lamotrigine leading to loss of seizure control and possibly decreased effectiveness of oral contraceptives. Physicians should provide special contraception instruction and encourage women of childbearing age to use non-hormonal methods of contraception. Caution should be exercised when discontinuing lamotrigine, as abrupt discontinuation of lamotrigine may trigger return of seizures, requiring a gradual reduction in dose, unless immediate discontinuation is imperative. During pregnancy, if treatment with Lamotrigine is necessary, the lowest possible dose should be used. Control must be ensured during treatment with Lamotrigine. The benefits of breastfeeding must be weighed against the risk of adverse effects on the infant. Because the drug's side effects on the nervous system can cause dizziness, tremor, irritability, it is necessary to pay attention to the body's reaction to the drug before driving or operating machinery.

Lamotrigine interacts with other antiepileptic drugs that are metabolized in the liver.

Side effects of Lamestad 100 may occur with the following frequency:
Very common side effects: headache, skin rash. Common side effects: Aggression, irritability, somnolence, dizziness, tremor, insomnia, agitation, nausea, vomiting, diarrhea, fatigue, dry mouth, pain, backache, joint pain. Uncommon side effects: ataxia, diplopia, blurred vision. Rare side effects: nystagmus, conjunctivitis, aseptic meningitis, Stevens-Johnson syndrome. Lamestad 100 is used to treat epilepsy and prevent depression in patients with bipolar disorder. However, the drug Lammostad 100 has many side effects, many notes when using the drug, so when using it, it is necessary to strictly follow the doctor's orders for effective and safe treatment for patients. You can ask your doctor right away if you have any questions about the medicine.
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