Uses of Lazilac

Lazilac has the main ingredient Lactulose, which is indicated in the treatment of constipation and hepatic encephalopathy. So what are the uses, dosages and notes when using Lazilac, let's find out through the article below.

Lazilac drug has the main active ingredient Lactulose, which is prepared in the form of an oral solution in a 15ml package. In the colon, lactulose is broken down by bacteria in the colon into low-molecular organic acids. These acids reduce the pH in the colonic lumen and have an osmotic effect that helps increase the volume of substances contained in the colon. This helps to stimulate bowel movements and relieve constipation. In addition, because the intestinal absorption of ammonia increases with pH, ​​a decrease in pH under the effect of lactulose will reduce ammonia absorption. A decrease in colonic pH also causes diffusion of ammonia from the blood into the intestine. In an acidic environment, colonic ammonia (NH3), which is diffusible, is converted to ammonium salts (NH4), which is non-diffusible, which prevents ammonia from dispersing into the blood. Besides, the effect of stimulating intestinal peristalsis also allows the elimination of ammonia from the body faster.

Lazilac has an osmotic laxative effect, lowers blood ammonia and is indicated in the treatment of pathologies including:
Constipation: Lazilac helps regulate physiological peristalsis of the colon. Used in cases where the production of soft stools is considered beneficial such as hemorrhoids, post-colon/anal surgery Hepatic encephalopathy: Treatment and prevention of hepatic coma or pre-coma.

3.1. Dosage Dosage will vary depending on the indication, severity of illness, and overall health of the patient. It is best for patients to consult a healthcare professional for the appropriate dosage. Here is the reference dose of Lazilac in some cases:
Treatment of constipation In the first 3 days, the dose is as follows: Adults and children over 14 years old: It is recommended to take 14ml to 45ml per day, can be divided make 1-2 times to drink. Children from 6 to 14 years old: It is recommended to drink 15ml per day, divided 1-2 times. Children 2m from 2 years old to 6 years old: It is recommended to drink 5-10ml per day, divided 1-2 times. Infants and children under 2 years old: It is recommended to drink 5ml/day, can be divided into 1-2 times. In the following days: Reduce dose according to disease progression and patient age. Prevention and treatment of encephalopathy caused by portal venous system (including hepatic encephalopathy) Adults: Initiation: It is recommended to take 15ml/time, 3-4 times a day, then gradually increase the dose to 30 - 45ml/time, drink 3-4 times a day. The dose is adjusted to suit each patient to have 2 - 3 soft stools per day. Children: Children: It is recommended to drink 3-9ml per day, divided into several doses. If the child has diarrhea, the dose must be reduced immediately, if the dose is reduced but the diarrhea does not stop, the drug should be stopped. Treatment of hepatic pre-coma or coma Rectal administration: It is recommended to dilute 300ml of the drug with 700ml of water (or Sodium chloride 0.9%), enema into the rectum and keep the drug in the rectum for 30-60 minutes, separated 4 - 6 hours indent 1 time. Other subjects: The elderly, patients with liver and kidney failure: The dose of Lazilac has not been determined in these subjects. 3.2. How to use Patients can take Lazilac directly or mixed with fruit juice, water or milk.

Lazilac is contraindicated in the following cases:
Patients with a history of allergy to the active ingredient Lactulose or any of its ingredients. Patients with colon diseases such as ulcerative colitis, Crohn's disease, abdominal pain of unknown cause. People who are on the Galactose diet because the composition of the drug contains a sugar similar to Galactose.

Patients using Lazilac may experience side effects including:
Endocrine and metabolic: Dehydration, hypernatremia, hypokalemia. Gastrointestinal: Abdominal cramps, bloating, diarrhea (if overdose), indigestion, flatulence, nausea, vomiting. Rarely, patients have pruritus, anal pain, or moderate weight loss. These disturbances may occur at the beginning of treatment and will be discontinued upon appropriate dose adjustment. If you experience unusual side effects, you should contact your doctor or pharmacist for advice.

Constipation should not be treated with Lazilac long-term. The use of Lazilac in constipation is only an adjunct to the treatment with a hygienic and dietary regimen. Patients should eat foods rich in fiber and drink plenty of water, increase movement and practice bowel habits. In infants and young children, laxatives should be used only when clearly needed, because of the risk of loss of normal bowel reflexes in the infant. Do not use Lazilac in cases such as galactosemia, intestinal obstruction or hypersensitivity to one of the components of the drug. If constipation does not improve after a few days of treatment with Lazilac or constipation recurs after treatment, you must see a doctor to find out the cause and get appropriate treatment. If Lazilac is used in patients with lactose intolerance, the amount of lactose contained in the drug should be considered. Diabetes: The normal dose used in constipation should not be a problem for people with diabetes. The therapeutic dose in humans (pre) hepatic coma is usually higher and should be taken into account. Electrolyte Imbalances: Periodically monitor for electrolyte imbalance when lactulose is used for more than 6 months or in patients with a predisposition to electrolyte abnormalities (eg, elderly, debilitated patients). Liver disease can cause patients to lose electrolyte balance. Infants using lactulose may experience hyponatremia and dehydration. Pregnancy: Lactulose is poorly absorbed after oral administration. Treatment of constipation in pregnant women is the same as for nonpregnant patients, and medication may be used when dietary and lifestyle modifications are ineffective. Lactulose can be used in pregnancy when an osmotic laxative is needed. Lactation: It is not known whether lactulose passes into breast milk; however, lactulose is poorly absorbed after oral administration. The manufacturer recommends caution when administering lactulose to a nursing woman. Drug Interactions: Because Lazilac has a pH-lowering effect in the colon, drugs that depend on colon pH for release (such as 5-ASA) may become inactivated. The article has provided information about Lazilac drug. The above information is for reference only. If you have any questions or need more information about your medication, you should contact your doctor or pharmacist for advice.