Uses of Markvil

Markvil belongs to the group of pain relievers, antipyretics, non-steroidal anti-inflammatory drugs, used mainly to reduce fever and pain in children. Refer to how to use Markvil through the article below to better understand the use of the drug.

Markvil is made in the form of soft capsules, the main ingredient is Ibuprofen 200mg.
Ibuprofen is a derivative of propionic acid, used in low doses to reduce fever and pain, and at high doses (> 1200mg/day) to have anti-inflammatory effects. Ibuprofen inhibits the synthesis of inflammatory chemical mediators such as prostaglandins through inhibition of the enzyme cyclooxygenase (COX), prevents leukocytes from migrating to inflammatory tissues, and reduces the sensitivity at the nerve endings to sensory nerve endings. pain-causing substances such as Bradykinin, serotonin... Therefore, the drug has analgesic, antipyretic, anti-inflammatory effects and is widely used in clinical practice. The antiplatelet effect of Ibuprofen is weaker than that of Aspirin.

Markvil is usually used in the following cases:
Use low doses in the treatment of pain such as headache, toothache, menstrual pain. High doses above 1200mg/day for the treatment of chronic rheumatic diseases, rheumatoid arthritis, ankylosing spondylitis, Fiessinger - Leroy - Reiter syndrome, psoriatic rheumatism and some rheumatic diseases causing pain and disabling complications. Treatment of acute exacerbations of peri-articular diseases (acute neck and shoulder pain, tendonitis,...); low back pain, severe radiculopathy or short-term trauma.

The dose of the drug depends on the condition of the disease.
Pain relief, antipyretic: Initial dose is 200-400mg/time, can be repeated every 4-6 hours if needed, but not to exceed 1200mg/day. Rheumatism: Attack treatment: Take 6 tablets/day, divided into 3 times. Maintenance treatment: Take 3-4 tablets/day, divided 3-4 times. Dysmenorrhea: Take 3 tablets/day, divided into 3 times. How to take medicine: Take the medicine with plenty of water, do not chew Markvil tablets and should be taken with meals.

Do not use Markvil in the following cases:
People with hypersensitivity to Ibuprofen or other NSAIDs. People with peptic ulcers or gastrointestinal bleeding People who are taking anticoagulants or other NSAIDs. Patients with severe liver and kidney failure. Children under 15 years old. Pregnant women in the first 3 months and the last 3 months of pregnancy. Women who are breastfeeding.

When using Markvil, patients may experience some of the following undesirable effects:
Digestive disorders: Nausea, vomiting, flatulence, indigestion, abdominal pain, diarrhea, constipation, stomach ulcers duodenum, gastrointestinal bleeding. Allergies, pruritus, urticaria, erythema, edema, headache, dizziness. When using Markvil, if the patient experiences any side effects, stop taking the drug and contact the treating doctor or go to the nearest medical facility for timely treatment.

When using concurrently Markvil may interact with some of the following drugs:
Concomitant use with other NSAIDs may increase the risk of ulcers and gastrointestinal bleeding. Concomitant administration of oral anticoagulants, parenteral heparin and ticlopidine increases the risk of bleeding due to inhibition of platelet function and impaired gastrointestinal mucosa. Combined with Lithium may increase the concentration of Lithium in the blood. Combination with methotrexate, especially at high doses above 15 mg/week, reduces the clearance of methotrexate, increasing its hematopoietic toxicity. The drug increases the concentration of cardiac glycosides ( Digoxin ) in the blood when combined with this medicine. Increased hypoglycaemic effect when combined with sulphonamide hypoglycemic agents: Ibuprofen may reduce the effect of antihypertensive drugs such as beta-blockers, ACE inhibitors or angiotensin-II receptor antagonists. , diuretics when used in combination. Ibuprofen in combination with corticosteroids increases the risk of gastrointestinal ulceration or bleeding.

When using Markvil, caution should be exercised in the following cases:
Ibuprofen should not be used together with other NSAIDs due to the increased risk of synergistic effects. When taking the drug with alcohol may increase adverse effects on the gastrointestinal tract or central nervous system. Use with caution in the elderly, hypertension, impaired liver/renal function. Should be combined with gastroprotective drugs when used in patients with a history of peptic ulcer or bleeding. Caution should be exercised when co-administered with anticoagulants, corticosteroids or antiplatelet agents due to possible increased risk of gastrointestinal bleeding. Should not be used by pregnant women in the first and third months of pregnancy or those who are breastfeeding. When taking the drug, be careful when driving or operating machinery. Above is some information about the use of Markvil, if you need advice or have any questions, please consult your doctor, pharmacist for advice.