Uses of Miraoflor

Each Miraoflo film-coated tablet contains the active ingredient Ofloxacin BP 200mg and excipients just enough. Ofloxacin is a fluoroquinolone antibacterial agent similar to ciprofloxacin, but oral ofloxacin has a higher bioavailability (up to more than 95%). Ofloxacin has a broad spectrum of antibacterial activity including: Pseudomonas aeruginosa, Enterobacteriaceae, Neisseria spp., Haemophilus influenzae, Streptococcus pneumonidae, Staphylococcus and a few other Gram-positive bacteria.
Ofloxacin is more active than ciprofloxacin against Mycobacterium leprae, and also against Mycobacterium tuberculosis and some Mycobacterium spp. other. Ofloxacin is bactericidal but the mechanism of action is not fully known. Like other antibacterial quinolones, ofloxacin inhibits DNA-gyrase, an enzyme essential in bacterial DNA replication, transcription, and repair.
Miraoflo drug is used in the following cases:
Treatment of pneumonia, severe bronchitis caused by bacteria; Treatment of Chlamydia infections of the cervix or urethra with or without gonorrhea, uncomplicated gonorrhea, urinary tract infections, prostatitis; Treatment of skin and soft tissue infections; Treatment of colitis caused by bacterial infection. Do not use Miraoflo in the following cases:
People with a history of hypersensitivity to Ofloxacin, other quinolones or any other ingredients in the preparation; Fluoroquinolone antibacterial drugs such as Ofloxacin, ciprofloxacin can cause articular cartilage degeneration in load-bearing joints in experimental animals. Therefore, this drug should not be used for children under 15 years of age, pregnant and lactating women.

Use the drug Miraoflo by taking it directly.
Dosage:
For adults: Pneumonia or bronchitis severe illness due to infection: Use 400mg every 12 hours, treat within 10 days; Chlamydia infection (in the ureter and cervix): 300mg every 12 hours, treatment within 07 days; Gonorrhea, no complications: Use 400mg as a single dose; Prostatitis: Use 300mg every 12 hours, treat within 6 weeks; Skin and soft tissue infections: Use 400mg every 12 hours, treat within 10 days; Urinary tract infections: Cystitis caused by K.pneumoniae or E.Coli: Use 200mg every 12 hours, treat within 3 days; Cystitis caused by other bacteria: Use 200mg every 12 hours, treat within 10 days; For adults with impaired renal function: Creatinine clearance > 50ml/min: Dosage unchanged, every 12 hours; Creatinine clearance 10 - 50ml/min: Dose unchanged, every 24 hours; Creatinine clearance < 10ml/min: Half dose every 24 hours; For children under 18 years of age: Miraoflo is not recommended. Overdose and treatment:
The most important signs to recognize acute overdose are CNS syndromes such as dizziness, palpitations, loss of consciousness, convulsions, intestinal reactions such as mucosal abrasions. stomach, nausea ; Ofloxacin can be removed by squeezing urine; Care should also be taken to apply ECG control because overdosage of Miraolfo has the potential to prolong the QT interval.

Usually Ofloxacin is well tolerated. The incidence of adverse events with ofloxacin, ciprofloxacin, and other fluoroquinolone antibacterial agents was similar to that seen with previous generation quinolones such as nalidixic. Some side effects patients may experience when taking Miraoflo include:
Common: Gastrointestinal disturbances, abdominal pain, diarrhea, nausea, vomiting, dizziness, headache, fatigue, insomnia, wide evil, tremor, visual disturbances; Uncommon: Pain and irritation at the injection site, sometimes accompanied by phlebitis and thrombophlebitis; Rare: Psychotic reactions, depression, hallucinations, convulsions, vasculitis, toxic necrosis of the skin, Stevens - Johnson syndrome; Treatment of Miraoflo side effects: Treatment should be discontinued if psychiatric, neurological and hypersensitivity reactions (such as severe rash) occur. In addition, patients should note to report to a specialist doctor about side effects when using Miraoflo for prompt handling instructions.

Some problems patients need to be careful and pay attention to before and while using Miraoflo are:
Miraoflo must be used with caution in patients with epilepsy or a history of central nervous system disorders. ; Caution in elderly patients, patients with hepatic impairment, renal impairment: Miraoflo dose should be reduced; Stop using the drug as soon as any signs of hypersensitivity occur; Need to drink a lot of water, do not take Miraoflo with food, avoid exposure to sunlight and UV rays while taking the drug; Pregnancy: Ofloxacin crosses the placenta, and it has also been detected in the amniotic fluid of more than 50% of pregnant women who used Miraoflo. There are no adequate studies on the safety of the drug in pregnant women. However, because Ofloxacin and other fluoroquinolones cause joint disease in young animals, Ofloxacin should not be used during pregnancy; Lactation: Ofloxacin is excreted in human milk at similar concentrations in plasma. Fluoroquinolones have been known to cause permanent damage to the cartilage of load-bearing joints and many other signs of arthropathy in young animals. Therefore, if other antibiotics cannot be replaced but still have to use Ofloxacin, the mother should not breast-feed while taking the drug; Effects of Miraoflo on the ability to drive and use machines: Ofloxacin can cause dizziness, visual disturbances affecting the ability to drive and use machines, so care should be taken.

Drug interactions can have some effect on the effectiveness of the drug or increase side effects. Therefore, the patient should inform the doctor about the drugs he has/are taking, the diseases he has had. At the same time, patients must not arbitrarily use, stop taking, change the dose or use of any medicine without the permission of the doctor.
Some interactions of Miraoflo drugs include:
Concurrent use of Ofloxacin with non-steroidal anti-inflammatory drugs (diclofenac, dipyrone, aspirin, paracetamol, indomethacin) does not increase the effect of causing psychosis (psychotic, euphoric). , hysteria). No special caution is required when using quinolones with non-steroidal anti-inflammatory drugs; Ofloxacin absorption is not altered by amoxicillin; Ofloxacin serum levels may fall below therapeutic levels when Miraoflo is used concomitantly with anti-magnesium agents and aluminum acids; Ofloxacin increases serum theophylline concentration by about 10%; Mineral salts, vitamins with iron or mineral salts, antacids containing aluminum, calcium, magnesium, sucralfate reduce the absorption of Ofloxacin. Therefore, Ofloxacin should be used 2 hours before or after the above drugs; The drug Miraoflo increases the concentration of warfarin, cyclosporin, increases the anticoagulant effect; Patients using antidiabetic drugs should pay attention to monitor their blood sugar while taking Miraoflo. During the use of Miraoflo, patients should pay attention to strictly follow the instructions from the doctor. At the same time, patients should fully keep in mind the above notes to achieve high treatment efficiency and limit possible unwanted effects.