Uses of Naturimine

Naturimine medicine contains the main active ingredient Dimenhydrinate 50mg, belongs to the group of psychotropic drugs. Naturimine is indicated for use in the following cases:
Prophylaxis and for people with motion sickness. Prevention and treatment of nausea due to different causes, except nausea caused by cancer chemotherapy. The use of Naturimine is contraindicated in the following cases:
Users are sensitive to Dimenhydrinate or any of its ingredients. Patients with narrow angle glaucoma; Urinary retention related to pathology in the urethra - prostate Subjects children under 2 years old. Pharmacodynamic properties:
Dimenhydrinate is an antihistamine, a sedative that induces sleep. The drug works by competing with histamine for the H1 receptor. In addition, Dimenhydrinate has anticholinergic, antiemetic and strong sedative effects. Dimenhydrinate is mainly used to treat vomiting in motion sickness and dizziness. The mechanism of these effects is related to dimenhydrinate reducing vestibular stimulation and auditory labyrinthine function, and the antiemetic effect may be due to the drug's action on the chemoreceptors. The CNS depressant effect usually subsides after a few days of treatment and the antiemetic effect may decrease after prolonged use. Pharmacokinetic properties:
Dimenhydrinate is well absorbed after taking the drug, the antiemetic effect is effective 15 - 30 minutes after oral administration. The drug works for 3-6 hours after taking the drug. Little is known about the distribution and metabolism of dimenhydrinate. Like other antihistamines, the drug can be widely distributed into the body's organs, crosses the placenta, and a small amount is distributed into milk. Dimenhydrinate is metabolised in the liver and eliminated mainly in the urine.

2.1. Dosage of the drug Naturimine The drug is taken orally, the patient can take it with food or milk to avoid stomach irritation. The recommended dosage when using Naturimine is as follows:
For motion sickness: Take at least 30 minutes before departure.
Adults: 1-2 tablets / time, after 4 hours by train, this dose can be repeated if needed. Children 8 - 12 years old: dose 1⁄2 - 1 tablet/time, take as above. Children 2 - 8 years old: 1⁄4 - 1⁄2 tablets every 4 hours. Prevention and treatment of vomiting and nausea:
Adults: take 1-2 tablets x 3 times/day. Children 8-12 years old: take 1 tablet x 3 times/day. Children from 2 to 8 years old: take 1⁄4 - 1⁄2 tablets x 3 times/day. Symptomatic treatment of Ménière: Take 1⁄2 - 1 tablet/time x 3 times/day for maintenance treatment.
2.2. Overdose and Management Some of the symptoms of overdose in children that are recommended include: pupil dilation, facial flushing, high fever, agitation, hallucinations, confusion, ataxia, convulsions , coma, respiratory failure, cardiovascular collapse and possibly death. Symptoms can occur 2 hours after taking the drug, death can occur within 18 hours.
In adults, doses of dimenhydrinate 500 mg or more may cause difficulty speaking and swallowing, psychosis indistinguishable from atropine poisoning.
Treatment:
There is no specific antidote to Naturimine overdose, but usually only symptomatic treatment. In the absence of convulsions, early gastric lavage can be performed to prevent aspiration of gastric contents, leaving the patient lying still to minimize CNS stimulation. If the patient has convulsions, treated with diazepam in adults and phenobarbital in children, symptoms develop more strongly, which may require the use of a ventilator.

The most common undesirable effect of dimenhydrinate is drowsiness. In addition, there are some unwanted side effects that users of the drug may encounter, including:
Common symptoms:
Appearance of symptoms such as drowsiness, headache, dizziness, dizziness, movement disorders Blurred vision Dry mouth and respiratory tract Tinnitus Rare symptoms:
Anorexia, constipation or diarrhea Urinary retention, difficulty urinating Tachycardia , hypotension Rare symptoms:
Paradoxical excitability often in children In adults, there may be agitation, tremor, insomnia, convulsions. When the above undesirable effects appear, it is necessary to immediately stop taking the drug and consult a doctor. If you experience rare symptoms or side effects that are not recommended in the instructions for use, immediately notify your doctor to get a diagnosis.

The effect of CNS depressants such as alcohol and barbiturates is enhanced when used with dimenhydrinate. Caution should be exercised when these products are used concurrently, as an overdose may occur. Dimenhydrinate may potentiate the effects of anticholinergics. Caution should be exercised when co-administering aminoglycoside antibiotics or other ototoxic agents, as dimenhydrinate may mask early symptoms of ototoxicity.

Some notes when using Naturimine drugs are as follows:
Avoid using Naturimine with alcohol or other central nervous system depressants, because it can increase the drowsiness effect and harm the user's body. Consider carefully before administering the drug to patients with chronic constipation, bladder obstruction, or enlarged prostate because the anticholinergic effects of the drug may aggravate the condition. The antiemetic effect of the drug can make the diagnosis of appendicitis difficult and mask the signs of toxicity in overdose with other drugs. Naturimine may mask symptoms of hearing impairment, caution should be exercised in patients taking particularly ototoxic drugs and close monitoring before co-administration of these drugs. Use caution when using the drug in the elderly, because it is easy to cause orthostatic hypotension, dizziness and nausea. Be careful when using the drug with patients who are allergic to dyes, because the drug contains sunset yellow color. For patients who are pregnant women: The drug should only be used when absolutely necessary for these subjects. Small amounts of dimenhydrinate are distributed into breast milk and pose a potential for adverse effects on the infant. Therefore, users of the drug should stop breastfeeding or not use the drug during this period. The drug has a drowsy effect, so do not use it while driving or operating machinery. Hopefully, the article has information about the uses, usage and some necessary notes about Naturimine to help you use the drug safely and maximize the effectiveness of treatment.
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